The Dobreva Lab

This issue features a Review synthesizing latest on RNA modifications research cell.com/cell/fulltext/…

Potential of mitochondrial transfer to prevent or treat Parkinson' s disease, in mouse and monkey models @CellCellPress cell.com/cell/fulltext/…

Nature research paper: Catabolism of extracellular glutathione supplies cysteine to support tumours go.nature.com/4bBphKQ

New issue alert👉cell.com/cell/current Yoshida et al. present 3D, single-cell-resolution atlases of multiple adult mouse organs and of the entire neonatal mouse. The artwork reimagines Klimt's decorative motifs to reflect the organization and vast scale of individual cells.

"Short-term fasting induces intratumoral accumulation of isoleucine, which reconfigures CD8+ T cell epigenetic programs and phospholipid remodeling, thereby licensing enhanced anti-tumor capacity."

Will we give a shot of protective, self-amplifying RNA in patients with a heart attack in the future? @ScienceMagazine an intriguing innovation science.org/doi/10.1126/sc…

CAR T cell therapy has shown strong results against certain cancers, but metabolic exhaustion limits its effectiveness over time. In @CellCellPress, the @MaayanLevyPhD & @ChristophThaiss labs report that a common supplement can fuel CAR T cells to fight cancer more effectively.

Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice dlvr.it/TRM0m9

Nature research paper: Peripheral immune-inducer dendritic cells drive early-life allergic inflammation go.nature.com/4aKOW4F

Some very good news about engineering our cells vs cancer (accelerating the CAR). A short thread 1. For background, a new 5★ review on cancer immunotherapy @Cancer_Cell sciencedirect.com/science/articl…

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection nature.com/articles/s4301…

✨New issue✨ Check out the latest in #Metabolism research from across all disciplines. Read about #AdiposeInnervation, #Amylin, #Cancer, #LiverMetabolism, #MitochondrialMetabolism, #Mycobiome, #Neurometabolism, #Redox, #T2D and many more topics! nature.com/natmetab/volum…

New! Online now: Neuroimmunometabolic co-evolution in the tumor micro- and macroenvironment dlvr.it/TRCh91

In a new Science study, researchers report on transcriptional adaptation, a dual feedback and feedforward mechanism that uses genetic redundancy to compensate for mutations in protein-coding genes. 📄: scim.ag/40whk4d #SciencePerspective: scim.ag/4s8ZCjf

Nature research paper: Functional dissection of complex trait variants at single-nucleotide resolution go.nature.com/4ck0zkd

Large-scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell-cycle and DNA repair regulation dlvr.it/TR5phY

Researchers in Science have created “cyborg” pancreatic organoids that combine stretchy miniature electronics with stem cell-derived pancreatic islets, using the implanted electronics to monitor electrical activity related to glucose regulation in maturing α and β cells. The "cyborg" organoids offer a path to study the biology and trace the maturation of α and β cells at the single-cell level, with an eye toward potentially treating or engineering new pancreatic islets in people with diabetes. Learn more: scim.ag/4rudIMg

The Koh Lab (medicine.yale.edu/profile/bongih…) is hiring!! Please reach out to join our newly established lab (now with an amazing graduate student and a very talented undergraduate student) as a Postdoctoral Fellow/Associate! Come help us write the first exciting chapter of our saga!

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

A new AI-enabled clinical decision support tool, TARGET-AI, was designed to help clinicians & larger health systems use AI more effectively. Learn more from @ekoikonomou about the need for targeted AI deployment. @YaleCardiology @cards_lab @rohan_khera medicine.yale.edu/internal-medic…