The Dobreva Lab

New! Online now: Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling dlvr.it/TSWySZ

Iron-dependent brain reshaping links social isolation to anxiety dlvr.it/TSVz9f

Exercise as a therapeutic intervention for long-lasting and chronic diseases dlvr.it/TSRmyy

In a new study, @Anders_S_Hansen Lab have measured chromatin movement at timescales ranging from hundreds of microseconds to hours, allowing them to rigorously quantify those dynamics for the first time. news.mit.edu/2026/how-chrom… @NatureSMB

Our best shot for preventing many diseases? Exercise A @Cell_Metabolism new review cell.com/cell-metabolis…

⭐️Don't miss this Review published @NatureCancer as part of our Series on Tumor Heterogeneity and Plasticity 'Heterogeneity and plasticity of cancer-associated fibroblasts' ✒️By Ruth Scherz-Shouval, Mara Sherman and co-authors 🔗nature.com/articles/s4301…

Butyrate extends health and lifespan in mice with mitochondrial deficiency nature.com/articles/s4146…

Anyone interested in the future of #cancer therapy must read this’ it’s best summary of latest findings of how brain controls cancer cell.com/cell/fulltext/…

Online Now: When tissue tension creates a mutagenic niche dlvr.it/TSKf3B

Almost all organs and tissues in the body can develop tumours, but those that affect the heart are seldom observed go.nature.com/4d7vRcT

High levels of micro- and nanoplastics around brain tumours might indicate breakdown of the blood–brain barrier go.nature.com/3QldkC6

🆕 @ScienceMagazine How do our cells have long term memory of inflammation that can later lead to persistent, chronic inflammation and disease? Through specific epigenetic chromatin changes, aka "memory domains" @ScienceVisuals science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

Now online! Hyperinnervation inhibits organ-level regeneration in mammalian skin dlvr.it/TRgJyc

This issue features a Review synthesizing latest on RNA modifications research cell.com/cell/fulltext/…

Potential of mitochondrial transfer to prevent or treat Parkinson' s disease, in mouse and monkey models @CellCellPress cell.com/cell/fulltext/…

Nature research paper: Catabolism of extracellular glutathione supplies cysteine to support tumours go.nature.com/4bBphKQ

New issue alert👉cell.com/cell/current Yoshida et al. present 3D, single-cell-resolution atlases of multiple adult mouse organs and of the entire neonatal mouse. The artwork reimagines Klimt's decorative motifs to reflect the organization and vast scale of individual cells.

"Short-term fasting induces intratumoral accumulation of isoleucine, which reconfigures CD8+ T cell epigenetic programs and phospholipid remodeling, thereby licensing enhanced anti-tumor capacity."

Will we give a shot of protective, self-amplifying RNA in patients with a heart attack in the future? @ScienceMagazine an intriguing innovation science.org/doi/10.1126/sc…

CAR T cell therapy has shown strong results against certain cancers, but metabolic exhaustion limits its effectiveness over time. In @CellCellPress, the @MaayanLevyPhD & @ChristophThaiss labs report that a common supplement can fuel CAR T cells to fight cancer more effectively.