Nikolina Docheva

I am excited to announce the GLOBAL CONSENSUS: MANAGEMENT OF PREGNANCY AND IBD is now published online! Jointly published in: @AGA_CGH doi.org/10.1016/j.cgh.… @AmJGastro @Gut_BMJ @IBDJournals @JCC_IBD @APandT

@XsyLocke @AMAZlNGNATURE @happypositive0 Some say that ancestors of the modern Bulgarians came from Pamir. The books on the nomad tribes from Pamir are fascinating but not many are available translated

Now that’s cool‼️ the Pamir Plateau, where the sheer vastness and raw beauty can feel as oppressive as a storm rolling across the Outback, yet as awe-inspiring as a rare critter sighting‼️ The Pamir Plateau, often dubbed the "Roof of the World," stretches across Tajikistan, Afghanistan, China, and Kyrgyzstan, with peaks soaring so high you'd think they were touching the stars. This is no ordinary place; it's a high-altitude desert where the air is thin, the silence is deafening, and the landscape is as stark as the moon's surface. The oppressive feeling comes from the sheer isolation and the overwhelming scale of it all - you're surrounded by towering mountains and endless plateaus that make you feel like a tiny speck in nature's grand design. The plateau's harsh climate, with its biting cold and relentless winds, adds to the sense of foreboding. It's a place where the elements rule, and human presence feels almost like an intrusion. The sparse vegetation and the rocky, barren terrain amplify this, making every step feel like a battle against the environment. Posts on X often highlight this eerie sensation, with travelers noting how the vastness can be both beautiful and intimidating, like staring into the abyss. But it's not just the physical environment; the cultural and historical weight of the Pamirs adds another layer. This is a land where ancient trade routes like the Silk Road once thrived, yet today, it's one of the most remote places on Earth. The few people who live here, often in small, isolated villages, embody a resilience that's both humbling and a bit daunting, reminding you of humanity's struggle against nature's might. The oppressive feeling is also tied to the altitude - averaging around 3,500 to 4,500 meters above sea level, it can leave you gasping for breath, both literally and figuratively. The low oxygen levels can mess with your head, making the already surreal landscape feel even more alien, as if you've stepped onto another planet. Yet, amidst this, there's a strange beauty. The Pamir Plateau is home to stunning vistas, with peaks like Ismoil Somoni (7,495 meters) and vast, glacier-fed lakes like Zorkul. The starkness is punctuated by moments of vibrant life - yaks grazing, rare Marco Polo sheep, and the occasional snow leopard prowling in the shadows. It's a place where nature's extremes are on full display, and that oppressiveness is part of its allure, drawing adventurers who crave the raw, unfiltered edge of the wild. while the Pamir Plateau might weigh heavy on your soul with its vast, unyielding presence, it's also a reminder of how magnificent and humbling our planet can be. This place is truly somewhere to test your spirit and marvel at the world's wonders!

The oppressive feeling of the pamir plateau

Does the brain change during pregnancy? You bet it does. How about doing 26 MRI scans on a single person pre-conception to 2 years post-partum. WOW! Laura Pritschet and colleagues nailed it with their new paper in @NatureNeuro. Key Points: - The authors point out that pregnancy is a period of profound hormonal and physiological changes. - The authors did something incredible by mapping neuroanatomical changes in an individual from preconception through two years postpartum. - Boom! There were pronounced decreases in gray matter volume and cortical thickness. - There were increases in white matter microstructural integrity, ventricle volume and cerebrospinal fluid. - There were few regions untouched by the 'transition to motherhood.' My take: This study shows us how a single brain in a single person can be a powerful resource when scanned serially over time. This method is hard to pull off, however what it has the potential to teach us about neuroscience is mind-blowing. Though this paper is only a single subject, the data provides a comprehensive map of the human brain across gestation. It will be interesting to add to the dataset, so we can understand changes across multiple persons and multiple conditions. The convergence of evidence is revealing that pregnancy as associated with dramatic neuroplasticity. How about a shout out to this 38-year-old woman who underwent 26 MRI scans along with blood draws from 3 weeks preconception through 2 years postpartum! nature.com/articles/s4159… #pregnancy #brain @ndosenbach @andreashorn_ @EMiddlebrooksMD

AJOG Special Report: A Lexicon for First-Trimester US: Society of Radiologists in Ultrasound Consensus Conference Recommendations: Specific normal and abnormal pregnancy location sites ow.ly/r4Hq50T8rA5

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn | New England Journal of Medicine nejm.org/doi/full/10.10…

An updated review of the evidence on magnesium for neuroprotection: ow.ly/BPFw50SL1e2

Promised Cures, Tainted Cells: How Cord Blood Banks Mislead Parents - The New York Times nytimes.com/2024/07/15/hea…

The effects of probiotics administration during pregnancy on preeclampsia and associated maternal, fetal, and newborn outcomes: a systematic review and meta-analysis - American Journal of Obstetrics & Gynecology MFM ajogmfm.org/article/S2589-…

@mel_UNIQUE @HopkinsGynOb So proud with you ❤️

I get to start my career as an OBGYN at my dream program!!!! @HopkinsGynOb

Ramadan fasting and pregnancy: an evidence-based guide for the obstetrician ow.ly/7Fp250QPGGE

Fetoscopic Endoluminal Tracheal Occlusion for Severe, Left-Sided Congenital Diaphragmatic Hernia: The North American Fetal Therapy Network Fetoscopic Endoluminal Tracheal Occlusion Consortium Experience - PubMed pubmed.ncbi.nlm.nih.gov/38128107/

@TimWenWhereWhat I couldn't go this year too 😭

the FOMO of missing #SMFM24 continues to hit hard :( but at least #MFMtwitter is keeping me updated!

@ProfAsmaKhalil Will these be available recorded for the folks across the pond? :)

We are delighted to announce the launch of monthly fetal medicine webinars. I look forward to sharing latest evidence and an interesting discussion with the leading experts in fetal medicine.

“The challenge of #preeclampsia screening is to detect high risk by combining at least 3 factors (risc factors, blood pressure and uterine artery Doppler) to give aspirin at 150 mg/d before 16 weeks, with very few exceptions”, @frafig

Respiratory syncytial virus (RSV) is a cause of substantial neonatal morbidity. Nirsevimab might protect infants against hospitalization due to RSV-associated lower respiratory tract infection. New research findings are summarized in a short video. nej.md/41Ic0uG

Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin gestations: a systematic review and meta-analysis ow.ly/WNJl50QaZns

Pineles et al. present the AMBLE study assessing ambulation for latency. See the full article at: ow.ly/Klh350Q9zUw

AJOG honors the memory of Philippe Jeanty, MD, PhD, a Giant in Obstetrics and Gynecology and pioneer in the study of fetal anatomy, biometry, growth, and congenital anomalies - ow.ly/mIFf50Qb8n0

@JezidMiranda @FIGOHQ Congratulations so proud with you. Very well deserved ☺️

It is a privilege to contribute to the advancement of maternal and fetal healthcare worldwide. In my new role, as chair within @FIGOHQ of the #health #strengthening Committee, we will put a great effort to promote quality, inclusive, and respectful care across healthcare systems.

In a follow-up report of a trial of CMV hyperimmune globulin in pregnant women with primary CMV infection, hyperimmune globulin did not improve hearing or developmental outcomes in children at the age of 2 years. Read the full report: nej.md/3u4w8Ky