Joshua C. Doloff

Aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal of aged T cells, or their secreted factor granzyme K, rescues cognition in mice @ImmunityCP @VilledaLab @UCSF cell.com/immunity/fullt…

Our latest paper is out @ScienceTM! Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts | Science Translational Medicine science.org/doi/10.1126/sc… #Immunotherapy #Fibrosis #Aging #Senescence #NKcell

@JainLaboratory @NatureBiotech Congrats Piyush and team!

1/ Today in @NatureBiotech, we published the first DNA-guided CRISPR that we originally reported in our 2024 preprint for detecting and targeting RNA in cells medrxiv.org/content/10.110…

@BenStiller Thanks for sharing him with the rest of us! May he be living it up in the great party in the sky!

Miss this man. 💙

🚨 Out today in Cell! @CellCellPress Path2Space: #AI that predicts spatial transcriptomics (ST) from H&E pathology, enabling spatial biomarker discovery in #BreastCancer at scale. 📄 doi.org/10.1016/j.cell… 🧵1/8

@JHUBME @HopkinsEngineer @NSF Alex Gorham got one this year as well.

Six current and former students from #HopkinsBME have been awarded the highly competitive @NSF Graduate Research Fellowship, which recognizes their potential to make meaningful contributions across a wide range of fields. Congratulations! 👏 👏 👏 bme.jhu.edu/news-events/ne…

👇 This! 👇 @aimbe

An 8-year-old girl and her mom were driving when they saw some motorcyclists crash. The mom, who is a nurse, rushed to help treat the injured. A year later, the girl started a lemonade stand; this is the motorcyclists' way of saying thank you…❤️

After months of looking my student @victorquiroz68 finally picked up one of the new @BreakthroughT1D Barbies for the lab! Left it on my desk as a surprise!

Sperm have long been thought of as streamlined DNA delivery vehicles, carrying little more than a father’s genes to the egg. But a new study shows that in mice, sperm may transmit the father’s influence in another way. During their passage through the epididymis, the coiled tube where they mature after leaving the testes, sperm pick up messenger RNAs (mRNAs), RNA transcripts of genes that contain the genetic instructions for making proteins. These mRNAs seem to be transferred to the fertilized egg, where they may affect the developing embryo. Learn more: scim.ag/41Qq7ir

@ahmetfcoskun Congrats Ahmet!

New CZI Funding! bme.gatech.edu/news/seeing-bi… Coskun and his team are building a platform called SMASH (Spatial Mechanomics with Active Surface Harvesting) to map the life of tissues across space and time. The team recently received an award from the Chan Zuckerberg Initiative.

@profmikeking @aimbe Hope the conversation went well.

Drs. Mike King (AIMBE President), Lola Eniola-Adefeso (AIMBE Immediate Past-President), and Dawn Beraud (AIMBE Executive Director) met with staff representatives from the BIOTech Caucus, as well as majority staff from the Senate Appropriations Committee… @aimbe

Science paper ! Do you ever wonder why there are no #cancers in the heart? Recent breakthrough...mechanical load turns on nesprin protein which stops #cancer science.org/doi/10.1126/sc…

#Mitochondrial fission promotes an ancient host defense pathway in mammalian macrophages and in worms, which could be exploited for future #antibacterial treatments. Learn more in Science #Immunology: scim.ag/3OYtG35

@KoladeAdebowal1 Thanks for the shoutout Kolade! Please give your students my regards. Hope they enjoyed the article! When all was said and done, it was over half of a decade of work.

Amplifying this tweetorial from students in my grad biomaterials class from a journal club discussion on a paper by Doloff et al. nature.com/articles/s4155…

@MorrisBioEng @NIH Congrats Aaron!

It's been a great few weeks for the PRIME lab. Excited to continue a long thread in chronic wounds from my PhD and very thankful for the support of @NIH!

5.5 years and two babies later, my postdoctoral work is finally out in Cell today! So very grateful to everyone who made this possible. Nuclear envelope budding enables export of large transcripts in muscle... sciencedirect.com/science/articl…

@DannyArends @pgonzrodriguez @Nature Cool. Thanks for that Danny!

@DannyArends @pgonzrodriguez @Nature Just curious: any direct links to immune function over time? Or other general systems of the body?

Our paper in @Nature today 🥳 We tracked 6,438 mice from puberty to death and mapped the genetics of *when* you die, not just whether a gene associates with lifespan. nature.com/articles/s4158… 59 loci. Two decades of data. Thread 👇 #Longevity #Aging #Genetics #Healthspan