Tullio

@Andercot land

Interesting that there is such a thing as "anti-entropic force" and it is basically "whatever intelligent life is trying to do" and that this is somehow fundamentally connected to the forwards arrow of time.

@photobiogenesis thoughts on algae based omega 3 oil with low oxidation (high quality)?

Most of the negative research around omega-3 fats just stems from the poor quality control of fish oil supplements As an example the standard wisdom has long been that omega-3 fats lower triglycerides but raise LDL, but in this study the increase in LDL only occurred with oxidized fish oil pubmed.ncbi.nlm.nih.gov/28558855/ How many of the effects of omega-3 fats are actually the results of oxidized fish oil being treated as equivalent to eating fish? Or the result of isolating these fats from the food matrix in general? Low-mercury fish and shellfish > fish oil

🚨 I HAVE NO MICROPLASTICS IN MY BALLS 🚨 This should not be possible. Studies show that 100% of men have microplastics in their semen. I am the first human ever to show a complete reduction to zero. This may be a world-first breakthrough in fertility research. I had 165 microplastic particles in my semen just 18 months ago. Now, I have zero. Five published studies have measured microplastics in human semen. Two found them in 100% of men. The other three found then in 44 to 76% of men tested, but those used methods that miss the smallest particles and the clear ones. Corrected for that, the real rate is likely 100%. Almost every man alive has plastic in his semen right now. The same applies to testicular tissue, testing 100% positive for microplastics. Microplastics hurt sperm. Human studies show the impact of various types of plastic, associated chemicals, and other toxins on male fertility: + 60% fewer normal shaped sperm (from PFAS) + 5x higher odds of low sperm count (from PTFE) + 10% lower sperm concentration (from PTFE) + 15% lower swimming ability (from PTFE) + 41% lower swimming ability (from PET) + 12% lower sperm swimming ability (from BPA) + 3x higher odds of low sperm count (from Phthalates) + 2x higher odds of poor swimming (from Phthalates) The effects compound: each extra type of plastic drops sperm swimming ability by about 21%. This matters even if you’re NOT trying to get pregnant. Sperm count is one of the cleanest biomarkers of overall health we have. And microplastics don't stop at the testes. The same particles are showing up everywhere we look. Studies show 4.5x higher rate of heart attack, stroke, and death in people with microplastics in their arterial plaque vs. those without. Microplastics were also found in 100% of human placentas tested. 100% of post-mortem human brains tested positive for microplastics. Brain concentrations rose ~50% between 2016 and 2024, and now sit at roughly 11x the levels found in the liver or kidney. Where do these come from? + PTFE, commonly in non-stick pans + PET, water bottles + Phthalates, makes plastic soft and bendy + BPA, can linings + PFAS, stain-resistant fabrics & food packaging Inside the body, plastic causes a kind of cellular rust. It triggers inflammation in the testicles, kills the cells that make sperm and drops testosterone. It's been confirmed across 39 animal and cell studies, then in human data. MY PROTOCOL: Note, what I did is n=1, not a controlled trial, I cannot prove cause. 1. Sauna (dry). My toxin blood panel confirms sauna clears plastic related chemicals: BPA, phthalates, PFAS, flame retardants, pesticides. The plastic particles themselves are too big to sweat out directly. Heat may activate other clearance routes: bile flow through the liver, the cell's internal cleanup system, and the gut barrier. Humans have almost no enzymes that can break plastic apart, so the body has to physically push it out. 2. Reverse osmosis water filter. Drinking water is likely a major source of microplastic getting into your body. A reverse osmosis filter pushes water through a very tight membrane and strains the particles out. I filter everything I drink. 3. Trying to rid my environment of the big plastic items: cutting boards, cups, plates, food storage containers, non-stick pans, cling wrap, tea bags, water bottles, kitchen utensils, kettles, and synthetic clothing. Note, as hard as I try, I'm always finding new plastic things in my life. This can be all-consuming thing so try to just knock out the big ones. I did all three interventions at the same time. I cannot say which one did the most work. What I can say is this: going from 165 to zero in 18 months is possible. Results: Nov 2024: 165 particles/mL Jul 2025: 20 particles/mL Apr 2026: 0 particles/mL The 18 month window also captures roughly 7 full spermatogenesis cycles.

@DeepDishEnjoyer big brain take is they learned project freedom polls badly so they're actually just going to rename it and are mentioning pakistan as keyword optimization

@notthreadguy @DeepDishEnjoyer > markets down > have you tried closing and reopening the strait of Hormuz

based

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Wittgenstein's (incredibly typical) response to a university friend taking him for a cheerful afternoon out to watch a boat race:

@photobiogenesis Why cut out nuts and beans and grains?

Some of my favorites tools include: - Magnesium glycinate (several doses spread throughout the day) - B1/Thiamine (I like the form benfotiamine) - Taurine (1/4-1tsp or 1-4g daily) - L-theanine (500-1000mg before bed) - Flax/chia/hemp seeds in yogurt/kefir for breakfast - Adding nutrient-dense foods like oysters, eggs, liver, meat, and dairy - Higher fiber intake from citrus, berries, avocados, etc - Sunlight exposure or infrared light therapy - An activated B-complex - Inositol (up to 1-2 tbsp daily) - Cutting out candy, soda, fried food, seed oils, and most nuts/beans/grains - Exercise that you enjoy - Grounding (walking barefoot) and spending time outside in nature Even just incorporating 2-3 things on this list can be enough to significantly improve your mental health and get you on track to feeling better

Most people would be shocked if they realized how many of their negative emotional states like depression, anxiety, and irritability are downstream of physical issues like low blood sugar, constipation, histamine/inflammation, and poor quality sleep I'll share a story from my own life that illustrates this: In my early 20's when I first got into nutrition I was eating plant-based vegan/vegetarian and working at a vegan "burger" restaurant It was whole food based and better quality than a lot of more processed options, but over time I noticed a consistent pattern I got one free shift meal per day, and around one hour after eating it I would consistently experience a bout of straight up suicidal depression and nihilistic thoughts I'm not someone who's prone to this usually, so it made me think something was VERY wrong, and over time I noticed that it only occurred when I would eat something off of the grill or fryer...

@bcherny The problems are not only in Claude code but also in the normal chat mode with text output. I’ve been trying to point this out for a while. Pls address

We’re resetting usage limits for subscribers. Thank you so much for your feedback and patience!

We’ve been looking into recent reports around Claude Code quality issues, and just published a post-mortem on what we found.

@photobiogenesis how much magnesium glycinate would you recommend? and any brands?

My top 5 health interventions: 1. Infrared light from sunlight and/or red light therapy 2. Magnesium glycinate paired with L-theanine before bed 3. Flax/chia/hemp seeds in kefir with breakfast 4. High dose thiamine 5. Reducing phosphate and increasing calcium and potassium

@pvncher opus 4.6 (when initially released) was much better and no amount of marketing from Anthropic will convince me it wasn't nerfed

Opus 4.7 is the first claude model I've seen make incorrect mcp tool calls.

@stevibe 4.6 opus when first released was better, more powerful. No amount of comments from Anthropic saying it wasn't nerfed over the last weeks /month(s) will convince me

Opus 4.7 first-hour impressions Ran the canvas tree growth test twice. 4.6: nailed the animation both times 4.7: static tree, no growth animation — twice 4.7's thinking is noticeably shorter and faster though (trimmed some 4.6 thinking in the clip for pacing). Not the upgrade direction I expected on this one.

I’m such an idiot I bought 2 dozen eggs right at the top

oh they didn’t get the business deal? The other exec must’ve smelled their low agency

I like all this 21st century mythbuilding wrt high agency people would be nietzschean if it weren’t old blatantly old values in disguise

no fear of rejection? High agency no addiction to heroin? high agency

@bcherny @GergelyOrosz @bcherny

@bcherny @GergelyOrosz 4.6 opus has definitely got worse over the last 10 days. Like substantially worse. Its written output is now much more repetition prone, syntax is the same over and over, and terminology is sloppier

Anthropic really is burning more and more dev goodwill Claude Code is suddenly getting unusable for stuff you could use it before (as in a day before!) and the AI now refuses to so stuff that it doesn’t think is strictly to do with software development. No transparency why ofc

@bcherny the quality of output by opus (extended) has gone down drastically wrt brainstorming, and general writing: lots of terms being repeated (structurally being one of its favorites) and in general a feeling of ai-written "slop" that wasn't there up to a few weeks ago, sup?