DrMilosSimic

A new grant from @Biohub will help @UChicagoPME Asst. Prof. @DrMilosSimic advance research aimed at detecting neurodegenerative diseases like Alzheimer’s and Parkinson’s decades before cognitive decline appears. 🔗 Read more: ms.spr.ly/6018vu52y #Biohub #UChicago #Alzheimers #Parkinsons

Thrilled and honored to share that the Simic Lab has been selected as one of 15 teams worldwide to receive a synthetic biology grant from Biohub! 🎉 Thank you! More here: biohub.org/blog/immune-ce… and pme.uchicago.edu/news/biohub-gr…

@UChicagoPME Thank you for the warm welcome ! I look forward to this next chapter!

We’re happy to welcome @DrMilosSimic as a Neubauer Family Assistant Professor of Molecular Engineering at @UChicagoPME! Dr. Simic is a synthetic immunologist and his research focuses on combining cell engineering and synthetic biology to understand and treat brain diseases. Welcome to the University of Chicago Pritzker School of Molecular Engineering, Milos! Learn more: pme.uchicago.edu/news/engineeri…

@ScienceKyle Amazing work! 🤩

🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.0…

Why test #celltherapies one-by-one when you can use multiplexed #SynBio, #proteinengineering & #ML to design, measure & track them at scale? The Goodman Lab @PennMedicine opens July 2025. We’re hiring Specialists & Postdocs! Apply @ bit.ly/42BnJNJ RTs appreciated!🙏

🚨Excited to share our latest work, now out in @NatureBiotech ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇 🔗 nature.com/articles/s4158…

Ligand-restricted synNotch switches enable precision cell therapy dlvr.it/THcbMP #immunology

Why treating neurological disorders like brain tumors is difficult - @PatrickHwuMD (@MoffittNews) @DrMilosSimic oncodaily.com/insight/patric… #Health #Medicine #Cancer #OncoDaily #Oncology #BrainTumors

#ScienceSaturday Treating #neurological disorders like #brain tumors is difficult in part due to a protective “wall” called the blood-brain barrier, meant to block toxins from reaching brain cells. ➡️ In this study, @DrMilosSimic, @NishRReddy, Et al. developed brain-sensing T cells, engineered to deliver brain tumor-specific chimeric antigen receptors upon sensing the brain tumor microenvironment. ➡️ This approach could pave the way for safer and more effective treatments for diseases like brain tumors, brain metastases, neuro-inflammation and more. 🔗 Here's a link to the full article: science.org/doi/10.1126/sc…

From suppressing unwanted immunity to inducing immunity where it counts, SynNotch-engineered T cell can carry diverse payloads to specific locations, allowing for customized effects in numerous treatments bit.ly/4gfNUh8 @DrMilosSimic @CDI_UCSF @parkerici @NishRReddy

@jsabatino37 Thank you @jsabatino37 ! Super excited it’s out!

@DrMilosSimic Fantastic work! Congratulations, Milos and team!

Check out our latest work on building “smart cells” with a tissue GPS to precisely treat some of the most challenging diseases without off-target toxicity. Brain targeting: science.org/doi/10.1126/sc… T cells with new immunosuppressive functions: science.org/doi/10.1126/sc…

Big news today: 2 papers and the cover of @ScienceMagazine! @NishRReddy et al. built T cells that suppress inflammation in specific tissues science.org/doi/10.1126/sc… @DrMilosSimic, Payal Watchmaker et al. built T cells that deliver therapies to the brain science.org/doi/10.1126/sc…

HUGE congratulations to my labmates @NishRReddy and @DrMilosSimic!! Making waves so big we almost had a tsunami today 🌊

THANKS TO THE TEAMS! Synthetic suppressor cell study by Lim Lab @CDI_UCSF @HebrokLab @AParent_lab @MaachiHasna @lillian_xyn @AtUcsf et al. Brain GPS study led by @DrMilosSimic Payal + @OkadaLabUCSF1 @parkerici @UCSF @OlgaTroyanskaya et al and now progressing to clinical trial.

🧭 TISSUE GPS | We designed tissue-sensing cells to deliver therapies specifically to the brain. This ‘brain GPS’ increases therapeutic specificity + efficacy to potentially treat diverse neurological diseases, including glioblastoma or multiple sclerosis. doi.org/10.1126/scienc…

P. Watchmaker, S. Gupta, Y. Wang, S. Sagan, J. Duecker, C. Shepherd, D. Diebold, P. Pineo-Cavanaugh, J. Haegelin, R. Zhu, B. Ng, W. Yu, Y. Tonai, L. Cardarelli, N. Reddy, S. Sidhu, O. Troyanskaya, S. Hauser, M. Wilson, S. Zamvil, H. Okada, and W. Lim

Thank you for the nice perspective highlighting our work: science.org/doi/10.1126/sc… And the cover: science.org/toc/science/38… Thank you to all the authors for this awesome work! It has been a fantastic journey!