David Dulin

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David Dulin

David Dulin

@Dulin_Lab

Assist. Prof. @VUamsterdam. #SARSCoV2 replisome, innate immune response, and nucleic acid processing motors at the single molecule level.

Amsterdam, The Netherlands Katılım Ekim 2016
1K Takip Edilen911 Takipçiler
David Dulin retweetledi
Craig Cameron Lab
Craig Cameron Lab@CameronLabUNC·
New work from @RKirchdoerfer lab in collaboration with Jamie Arnold and @Dulin_Lab reveal the potent, inhibitory activity of arabinoside incorporation on elongation by both coronavirus and enterovirus RNA polymerases. The major problem with utilization of this class of nucleoside is the poor conversion to the triphosphate in the cell. We are now working on strategies to address that issue. jbc.org/article/S0021-…
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Keith J. Mickolajczyk
Keith J. Mickolajczyk@KJMbio·
Our preprint on reconstituting DNA uptake during natural transformation is now posted! An exciting new role for reversible DNA bridging proteins. Congrats to all authors! Reversible DNA condensation drives natural transformation biorxiv.org/content/10.110…
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David Dulin retweetledi
Daniel Hurdiss
Daniel Hurdiss@DanielHurdiss·
Interested in our recent norovirus NS3 work? 👇 Join us to dig deeper! I'm recruiting a PhD candidate to investigate NS3's role in viral replication and assembly using #cryoEM, #cryoET, and other complementary techniques. 🔗 tinyurl.com/4f3t3aae Please share! 🙏
Daniel Hurdiss@DanielHurdiss

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of norovirus replication (🧵) 🔗biorxiv.org/content/10.110…

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Craig Cameron Lab
Craig Cameron Lab@CameronLabUNC·
Had the chance to spend time with @Dulin_Lab. Went to a restaurant on the dock, and we sat right on the dock.
Craig Cameron Lab tweet media
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David Dulin retweetledi
Danny IncaRNAto
Danny IncaRNAto@incaRNAtolab·
The IncaRNAto lab is seeking a motivated #PhD candidate, interested in studying #RNA structural ensemble dynamics in living cells. Here's the link to the vacancy: rug.nl/about-ug/work-…. Please share!
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David Dulin
David Dulin@Dulin_Lab·
Thanks for having us on this nice work, @DanielHurdiss! ☺️
Daniel Hurdiss@DanielHurdiss

@MRHerodDR Does our hex-NS3 construct bind RNA? 🧬 Yes! Single-molecule magnetic tweezers experiments with the @Dulin_Lab indicate binding to ssRNA and dsRNA, with compaction of the latter. No ATP-driven helicase activity detected (thoughts on that in the paper).

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F. Moreno-Herrero
F. Moreno-Herrero@FMorenoHerrero·
Our latest work is out in @NAR_Open! 🚀 In collaboration with Silvia Ayora’s group @CNB_CSIC, we show that bacterial RecD2 binds long ssDNA, translocates 5′–3′ over >20 kb, and exhibits force-enhanced unwinding and strand switching at DNA forks. academic.oup.com/nar/article/53…
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Subhas C. Bera
Subhas C. Bera@b_subhas·
I'm delighted to join Dr Shubhasis Haldar's (@HaldarShubhasis ) lab @snbkol as DBT-RA. Thanks to @DBTIndia for considering me for the prestigious fellowship. Excited to develop more Single-molecule techniques and solving complex Bio-Medical problems!
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David Dulin retweetledi
Craig Cameron Lab
Craig Cameron Lab@CameronLabUNC·
A new preprint. We reveal the response of the enterovirus polymerase to a break in the template its copying. Different from homologous recombination. This attribute will facilitate attachment of adapters to RNA for applications like nanopore sequencing. biorxiv.org/content/10.110…
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Christian Speck
Christian Speck@Speck_Lab·
📢New Publication Alert📢 Here, we investigated how DNA insertion during pre-RC formation is linked to Mcm4 ATP hydrolysis. Congratulations to @morvorenlowen @ma89rta MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis | Nature Communications
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Tineke Lenstra
Tineke Lenstra@tinekelenstra·
Immensely honored and happy to receive the ERC Consolidator Grant! Looking forward to image many more single molecules in the coming years.
The Netherlands Cancer Institute@NKI_nl

NKI researcher @tinekelenstra has been awarded the 2024 ERC Consolidator Grant from @erc_research. “A wonderful recognition of our work,” Tineke says. Her team will use the grant to continue their research into gene regulation. Read more ➡️ bit.ly/3BdsHFo

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David Dulin retweetledi
NWO Nieuws
NWO Nieuws@NWONieuws·
Official pictures and recap from NWO Biophysics 2024 are now available! Thanks to everyone who contributed to the success of this event and hopefully until next year at NWO Biophysics 2024! View the pictures and recap here: nwobiophysics.nl/imagery. Vertaling weergeven
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David Dulin
David Dulin@Dulin_Lab·
📢 Onderwijs en onderzoek zijn cruciaal om de grote vraagstukken van onze tijd aan te pakken! Toch bezuinigt het kabinet-Schoof €1 miljard op hoger onderwijs en wetenschap. Wij komen in actie tegen deze bezuinigingen! Teken jij ook de petitie? campagnes.degoedezaak.org/campaigns/stop…
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Keşfet

@RKirchdoerfer @KJMbio @CameronLabUNC @DanielHurdiss @FMorenoHerrero @CNB_CSIC @b_subhas @HaldarShubhasis