@more@

Ik vraag me nu al af met welk virus de vleermuizen ons volgend jaar gaan pesten.

@Nature The news article suggests it inhibits replication, but it does not inhibit the replicating enzyme RdRp but the main protease. Just like nirmatrelvir but this time non covalently.

An antiviral pill has, for the first time, been shown to prevent COVID-19 in people exposed to the SARS-CoV-2 virus go.nature.com/3P8GUKS

@HenkJanOut En weer voor 11 miljard

Daar gaan we weer

@truedat999 @Rainmaker1973 Good reply. The article in the post is quite old.

The field has crossed into human testing in 2026 (huge milestone!), but only for targeted eye diseases—not the "50-year-old skin acting 20 again" application from the post. Life Biosciences (building on David Sinclair's work) received FDA IND clearance on January 28, 2026, for ER-100, the first-ever partial epigenetic reprogramming therapy to enter humans (NCT07290244 on ClinicalTrials.gov). The Phase 1 trial is now recruiting: it involves a single injection of an AAV-delivered OSK gene therapy (Oct4, Sox2, Klf4—Yamanaka factors minus c-Myc) into one eye of patients with open-angle glaucoma (OAG) or non-arteritic anterior ischemic optic neuropathy (NAION). It's inducible (via doxycycline) for controlled, transient expression to minimize risks. The primary focus is safety, tolerability, and immune responses, with secondary checks on visual function (e.g., acuity, OCT scans). Dosing started sequentially (one patient, 28-day wait, then next), with enrollment ramping up after site activation in early 2026. First safety data could emerge late 2026 or early 2027; the study runs through ~2032 for long-term follow-up. The Babraham Institute's 2022 skin fibroblast work (13-day transient reprogramming resetting ~30 years on epigenetic clock, boosting collagen and wound closure in dishes) remains preclinical—no human trials yet as of March 2026. Recent efforts (e.g., 2025 partnership with Axol Bioscience) aim to refine efficiency and reduce Yamanaka factor reliance, but no direct clinical push for skin applications is announced. No other partial reprogramming trials are active in humans for skin, cosmetics, broad anti-aging, or other tissues right now. Turn Biotechnologies (mRNA-based transient expression for skin) and others are prepping or in preclinical stages—no registered human studies yet. Some companies (e.g., Rejuvenate Bio) have shown lifespan extension in mice with OSK, but human translation lags. For the skin-specific "rejuvenated fibroblasts" to become a real clinic treatment (e.g., injections/topicals for collagen boost, elasticity, wound healing like younger skin): - Best-case (3–8 years, ~2029–2034): Eye trial success on safety (and any efficacy hints) would de-risk the platform massively, speeding funding, regs, and follow-on trials in accessible tissues like skin (chronic wounds, dermatology, fibrosis). Localized delivery could accelerate skin/derm paths. - More realistic (10–20+ years, 2035+): Broad, approved, Botox-level options require large Phase 2/3 trials proving durable benefits/safety (e.g., no cancer risk from factors), acceptance of aging as a treatable indication (not standard yet), non-viral/scalable delivery (creams, injections), and affordability. It's genuine, accelerating progress—not vaporware—but this is literally the starting line for human data on partial reprogramming. Don't expect anti-aging skin treatments soon; patience remains essential. Exciting times ahead, though!

Scientists just made 50-year-old skin cells behave like they’re 20 again. Researchers at the Babraham Institute in Cambridge have developed a groundbreaking method to reverse the biological aging of human skin cells by approximately 30 years, all while keeping them as fully functional adult skin cells. The team used a carefully controlled, short-term version of the Nobel Prize-winning Yamanaka reprogramming technique. By exposing adult skin fibroblasts to a specific set of reprogramming factors (the Yamanaka factors) for just 13 days—and then stopping the process early—they successfully “reset” many molecular markers of aging without pushing the cells all the way back to a stem cell state. After this brief treatment, the rejuvenated cells displayed a dramatically younger profile: their epigenetic clock (a measure of chemical tags on DNA that tracks biological age) and their gene expression patterns (the transcriptome) closely resembled those of cells from much younger individuals. Even more impressively, the cells behaved younger too. The treated fibroblasts produced significantly higher levels of collagen—the protein essential for skin firmness, elasticity, and wound healing—and they migrated faster to close an artificial “wound” in laboratory dishes compared to untreated older cells. The researchers also observed reversal of age-related changes in genes associated with diseases such as Alzheimer’s and cataracts, suggesting the technique could have broader therapeutic implications. While this work is still in its early stages and the precise mechanisms remain under investigation, the findings open exciting possibilities: one day, scientists may be able to selectively rejuvenate aging cells in the body to enhance tissue repair, improve healing, and potentially slow or mitigate some effects of age-related diseases—without the risks associated with fully reprogramming cells into stem cells. [Gill, D., Parry, A., Santos, F., Okkenhaug, H., Seale, M., Dobbs, L. J., Reik, W., & Ocampo, A. (2022). Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. eLife, 11, e71624. DOI: 10.7554/eLife.71624]

@milosmakesmaps The IJsselmeer should be white Milos

Netherlands🇳🇱packs 18.0M people into 33,720 km², that is 540 ppl/km². My map shows the Randstad arc, about half the population, burning brightest, with smaller clusters beyond. Beautiful… and sobering amid housing and space pressure. Densify the core, or spread growth?

@CasperHuls Geweldige boeken idd

Gelezen: Jack Vance - City of the Chasch (1968). Eerste van vier boeken in de 'Planet of adventure'-reeks. Over Adam Reith, die neerstort op de planeet Tschai, waar mensen slaven zijn van verschillende volkeren die elkaar naar het leven staan. Genieten, weer. #casperscollectie

@T_Fitzright Ik “run” het tijdelijk. Valt niet mee.

Ik volg de situatie op de voet.

@simongerman600 So they were just searching for tomatoes and colonisation was accidental?

This map shows the number of years each region was part of the Roman Empire. Everything bordering the Mediterranean was at some point part of the Roman Empire. Crazy fact. Only thing crazier is that the whole history of the Roman Empire was entirely tomato-free (They were only introduced in the mid-1500s to Italy).

@MarionKoopmans Precies. Als Europa mee wil blijven doen moeten ze de treinreizen verbeteren.

Ik wil echt liefst per trein reizen in europa. Maar het gaat wel zo 🤬🤬🤬🤬🤬 vaak mis…nu circa 8 uur om van hamburg thuis te komen, 470 km. Ze zeiden nog zo: ga vliegen. Bizar. Prioriteiten in de europese politiek

@raouljdegroot Precies dat. De twee landen met de beste inlichtingendiensten zijn zijn baas

Als Europa Oekraïne echt wil helpen dan geven we Zelensky geen wapens, maar de Epstein files en een plasseksvideo.

@MarionKoopmans Filo Virus Disease?

Waarom krijg ik continue FVD reklame in mijn TL?

@aboutpharmac 30?

30 COMMON MEDICINES AND THEIR USES

@travolax Bad timing

@DrNeilStone Before 1879?

So how did autism happen before Tylenol was available?

@Civixplorer @simongerman600 When Gaza was still in South East Africa

Map of Africa in 1880 AD. Before the European "Scramble for Africa".

@MartinKoolhoven Dit is toch een still uit 300 over de helden van Sparta?

Kom op, Johnny. Prove them wrong.

@Denkjewel Juist. Zo pak je een plaag aan

@Ed_Moret De Amerikaanse rivierkreeft moet in mijn soep.

Epe vandaag. Elke dag weer wolvenconfrontaties waarbij die zogenaamd """schuwe""" roofdieren volledig gehabitueerd gedrag vertonen. Het is wachten op grote ongelukken.

@Denkjewel Zodra hij de Aziatische hoornaar en de Amerikaanse rivierkreeft gaat jagen mag hij blijven

Iedere wolvenliefhebber die serieus denkt dat onze """natuur"""gebieden en de bebouwde grotemensenwereld perfect gescheiden entiteiten zijn is niet goed snik en zou eigenlijk niet meer mee mogen debatteren.

@milosmakesmaps Are you 2.05?

I'll be fine

@DrNeilStone 42 is the answer

RFK Jr is going to announce the cause of autism by September The cure for cancer in October The final digit of PI in November And the Meaning of Life by December

@SherminAmiri Die mensen verdienen de steun van onze regering.

De proteststem in Israël wordt luider: ‘We are not our government!!’ klinkt op straat. Steeds meer Israëli’s nemen nadrukkelijk afstand van de regering in Jeruzalem.