Edward Marcotte

We're hiring postdocs. Think deep homology meets proteomics. Discover ancient biochemical systems, invent new tech, or study the structure/function/evolution of proteins in embryonic development. Please RT! Email CV, interests, & references' contact info to marcotte@utexas.edu

Published @ScienceAdvances. From our proteomic atlas of the ERECTA signaling network, we show that removing receptor kinase by endocytosis is essential for stomatal patterning. Congrats, Pengfei @edward_marcotte @hhmi_scienc @texasscience & co-authors! science.org/doi/10.1126/sc…

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

David Botstein was a towering figure in genetics, genomics and biology. He was a mentor of extraordinary impact, which I experienced personally as a PhD student in his group at Princeton University. He will be remembered for his incisive and formidable intellect, his strong and unapologetic opinions, and his deep, unwavering commitment to his students and to the broader scientific community. David contributed bold and generative ideas to genetics and genomics. His insight that associations among polymorphic loci could be used to identify the genetic elements underlying diverse phenotypes fundamentally influenced early efforts in mapping and understanding the genetic basis of traits and disease. He was also a pioneer in the early development of DNA microarrays to measure RNA abundance, helping to lay the foundation for the field of genomics and large-scale, quantitative biology. Yet beyond these landmark scientific contributions, David’s most enduring legacy may be the generations of scientists he trained and inspired. He emphasized rigor, clarity of thought, and the courage to pursue big, important questions. He demanded intellectual honesty and rewarded genuine curiosity. I count myself among the many who benefited from his mentorship. His influence lives on not only in the discoveries he made, but in the standards he set and the minds he helped shape.

NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true. Here is a graph showing how many fewer new funding opportunities that NIH has posted over time. -91%, a trend that started on Jan 2025.

以前朝日新聞の論座に寄稿した解説。現在はアーカイブされていますが、ポイントを押さえた解説は以下のスレッドからどうぞ。Jason本当におめでとう。今の米国政府のワクチン開発への風当たりの中で、研究成果がきちんと評価され懸賞されることはとても嬉しい。 x.com/KeikoUTorii/st…

As the planet gets hotter & drier, can we make proteins & organisms more resilient to desiccation stress? Together with @shaharsu @SyracuseU & @alexholehouse @washumedicine, we show in @CellSystemsCP a sequence grammar encoding tolerance to dehydration. cell.com/cell-systems/a…

@fried_lab @JohnsHopkins Congratulations, Stephen! Very well deserved!

My promotion and #tenure is now official @JohnsHopkins. Just feeling really happy and grateful for my students, colleagues, family, and friends. You've made the last 7 years in #Baltimore some of the best in my life! 😁

Excited to share work with @ZhidianZ, Milot Mirdita, Martin Steinegger, and @sokrypton biorxiv.org/content/10.110… TLDR: We introduce MSA Pairformer, a 111M parameter protein language model that challenges the scaling paradigm in self-supervised protein language modeling 🧵

Excited to share our preprint “BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design” — a collaboration with @MartinPacesa, @ZhidianZ , Bruno E. Correia, and @sokrypton. 🧬 Code will be released in a couple weeks

It. Is. On!!! Stand up for Science, Austin! 4pm. South steps of the Texas Capitol. Be there!

This is horrible news for numerical weather prediction in this country. The data that comes from these key parts of our weather enterprise saves lives. DOGE moves to cancel NOAA leases on key weather buildings axios.com/2025/03/03/dog…

NCEP is the nucleus for all weather data in the United States. If this true and there is any lapse in coverage, it will make it nearly impossible for ANY weather entity to predict a severe weather event due to lack of computer model functionality. This is a huge deal. @DOGE

“Also in limbo are the intramural program’s trainee programs. One, a “postbac” program that employs some 1600 recent college graduates, is key to staffing many labs and launching young scientists’ careers, one NIH senior scientist says.” science.org/content/articl…

I'm quoted in this article on how NIH is still blocked from funding new grants. This sabotage makes no sense. Nearly every medicine or treatment you've ever received has roots in NIH-funded research, and every $1 of NIH spending generates $2.46 in returns. wbur.org/news/2025/02/2…

NIH serves the US public. If you value the ability to get diagnosed and having treatments to a disease when you or a loved one get sick (cancer, Alzheimer’s, heart or kidney disease, diabetes, etc) please consider calling your representative. This has to be stopped. #SaveTheNIH

Friends, I am at a loss of words for how devastating it would be to lose the entire intramural #NIH program. Some of the biggest medical and scientific breakthroughs have come from scientists in the NIH Intramural program. #SaveTheNIH science.org/content/articl…

Gutting the NIH will kill Americans: - Patients lose access to lifesaving medicine - 1000s of lost jobs at NIH and across academia - No research funding = no new medicines and treatments - Fewer trainees/medicines = pharma + health sector crash These are only a few. Buckle up.

NIH funding creates medicines, jobs, and economic growth

NIH has stopped considering new grant applications, delaying decisions about how to spend millions of dollars. The freeze occurred because the Trump administration has blocked the NIH… npr.org/sections/shots…