Eleftheria Zeggini

Our Scientific Council met for the first plenary in its new constellation! Meet our six new members and our three new Vice-Presidents: link.europa.eu/NdwjMm Learn more about our independent governing body: link.europa.eu/CPH7DW

Very proud to share our study published in Nature Metabolism ! 🥳 Find more details below on the molecular mechanisms causal to T2D 🧬 nature.com/articles/s4225…

Mapping Proteins in African Genomes – New Clues for Type 2 Diabetes 🧬 👉 t1p.de/3n22e A new study led by #HelmholtzMunich, reveals how genetic and proteomic data from African populations can uncover previously unknown biological pathways in type 2 diabetes. Their work addresses a long-standing gap by studying a population grossly underrepresented in medical research. 💡 By analyzing blood plasma proteins in a Ugandan cohort, researchers identified 18 proteins with a likely causal link to #T2D – including targets for existing drugs. Several protein patterns were unique to African ancestry, highlighting the need for population-specific diagnostics and treatments. The findings could pave the way for earlier and more accurate #Type2Diabetes diagnoses, as well as treatments tailored to African populations. 💬 “By focusing on African populations, we are uncovering biological insights that have been missing from global diabetes research. This work shows that a one-size-fits-all approach to diagnosis and treatment is not enough – we need solutions that reflect the diversity of human biology.” – Dr. Opeyemi Soremekun, first author of the study and former Humboldt Research Fellow at Helmholtz Munich. 💬 “Our findings lay the groundwork for future clinical applications, from improved diagnostic markers to potential therapeutic targets. By embracing genetic diversity in research, we can move closer to precision medicine that works for all.” – Prof. Eleftheria Zeggini, Director of the Institute of Translational Genomics at Helmholtz Munich The team plans to expand the research to more African populations, aiming to close equity gaps in #GlobalHealth and move toward #PrecisionMedicine for all. 🔗 To the original publication: t1p.de/9qgha @EleZeggini @OpeSoremekun @SFatumo @CompHealthMuc @The_MRC @UVRIug @UKZN @TU_Muenchen #Genomics #Proteomics

🎄 We’re hiring in Health AI at @HelmholtzMunich! 🔹 PIs in Health AI/AI Foundations 🔹 Health AI Fellows (independent postdocs) 🔹 Clinical AI Consultants (with TUM, LMU, M1) Apply👇 PIs: jobs.helmholtz-muenchen.de/jobposting/83f… Fellows: jobs.helmholtz-muenchen.de/jobposting/754… Consult: jobs.helmholtz-muenchen.de/jobposting/c7b…

Eleftheria Zeggini Appointed to the ERC Scientific Council 🎉 👉t1p.de/0k3y2 The European Commission has appointed Prof. Eleftheria Zeggini to the Scientific Council of the European Research Council (ERC) – the ERC’s governing and decision-making body. Prof. Zeggini is the Founding Director of the Institute of Translational Genomics at #HelmholtzMunich and a TUM Liesel Beckmann Distinguished Professor at the Technical University of Munich, School of Medicine and Health. 🔬 Eleftheria Zeggini’s research focuses on translational genomics, with an emphasis on developing and applying statistical and computational methods to integrate molecular, genomic, and epidemiological datasets. She uses approaches such as large-scale GWAS to study complex diseases like type 2 diabetes and osteoarthritis, aiming to uncover shared mechanisms that drive their development and progression. Her goal is to translate these insights into better prevention strategies and more personalized treatment approaches. 💬 “It is an honor to join the ERC Scientific Council. I look forward to contributing to its mission of supporting frontier research and fostering scientific excellence across Europe.” – Prof. Eleftheria Zeggini 💬 “Helmholtz Munich is committed to scientific excellence and regards the ERC as a cornerstone of EU research funding. Eleftheria Zeggini’s appointment is a testament to her outstanding scientific achievements and leadership in science. This recognition by the ERC Scientific Council underscores the global impact of her work.” – Prof. Martin Hrabě de Angelis, Member and Spokesperson of the Executive Board (acting) at Helmholtz Munich The ERC Scientific Council is composed of distinguished scientists and scholars representing the European research community. Its members define the ERC’s scientific strategy and select peer-review evaluators – shaping the future of frontier research in Europe. @EleZeggini @ERC_Research @TU_Muenchen #ERCScientificCouncil #ERC #Genomics #Translation #ResearchExcellence

Helmholtz Munich Launches Pioneering Osteoarthritis Research Project With EU Partners 👉t1p.de/64zie #HelmholtzMunich is part of #PROBE, a new EU-funded initiative aiming to transform how #osteoarthritis is diagnosed and treated. The project is supported by Horizon Europe through the Innovative Health Initiative and has a total budget of €26 million – €1.4 million of which is allocated to Helmholtz Munich. 🧬 Building the foundation for #PersonalizedMedicine Osteoarthritis affects more than 500 million people worldwide. PROBE will integrate data from over 70 million individuals – enabling AI-driven analyses, predictive models, and innovative clinical study designs that pave the way for more precise diagnostics and tailored therapies. 🔍 Accelerating clinical impact The consortium of 38 partners brings together expertise in #AI, data protection and ethics. The project aims to establish innovative endpoints, enhance therapy evaluation, and support shared decision-making for patients and clinicians. 💬 “With PROBE, we are uniting expertise and data across Europe to take osteoarthritis research to the next level. AI-powered analyses of federated multimodal data at unprecedented scale provide the foundation for personalized therapies and more efficient clinical trials – all with the clear goal of sustainably improving the quality of life for the hundreds of millions of people affected.” – Prof. Eleftheria Zeggini, who leads Helmholtz Munich’s contribution to PROBE @EleZeggini @fabian_theis @ja_schnabel @heinig_matthias @CompHealthMuc @HorizonEU @Novartis #Osteoarthritis #AIinHealth #HorizonEU #OA #BigData

@mendel_random Congratulations, George!!

Honoured to receive the 25th Anniversary MRC Millenium Medal. My mid-1980s epidemiological apprenticeship was at the MRC Epidemiology Unit in Cardiff in the mid-1980s, and my senescence with the MRC IEU, closing in March 2028 🙏 MRC! ukri.org/news/mrc-mille…

@fabian_theis Congratulations, Fabian! Richly deserved!

Very honored to receive the 2025 ISCB Innovator Award at #ISMBECCB2025 and present our lab’s journey—from mapping cells to modeling their future. Thanks to my amazing team and collaborators—this is our award! 🙌 📝 doi.org/10.1093/bioinf…

@nicolesoranzo @ERC_Research @humantechnopole @sangerinstitute @Cambridge_Uni Congratulations!

So excited that our team was awarded an #ERCAdG grant @ERC_Research this year. A testament to the brilliance, hard work and dedication of my present and past teams @humantechnopole @sangerinstitute @Cambridge_Uni. 🤩🤩

Twenty years of genome-wide association studies. Always worth reading ⁦@EleZeggini⁩ nature.com/articles/d4158…

Amazing paper! Congratulations, @EleZeggini and collaborators, on the gigantic work!!!! 👏 Translational genomics of osteoarthritis in 1,962,069 individuals nature.com/articles/s4158…

Osteoarthritis – Largest Genetic Study Reveals New Drug Targets 🧬 👉 t1p.de/acynm An international team led by Prof. Eleftheria Zeggini, #HelmholtzMunich, has conducted the largest-ever genome-wide association study (GWAS) on osteoarthritis, analyzing data from nearly 2 million individuals. 💡 Their findings offer new hope for millions suffering from the disease – they pave the way for personalized therapies and better trial designs. 💬 “What we found in the largest osteoarthritis GWAS study not only advances our understanding of the disease but also lays the groundwork for developing more effective and personalized therapies that could transform osteoarthritis care.” – Eleftheria Zeggini @EleZeggini @TU_Muenchen @CompHealthMuc #Genomics #Osteoarthritis #DrugDiscovery #PrecisionMedicine #PersonalizedTherapy #TranslationalResearch #GWAS

⏳ Only 10 days left to apply for our Principal Investigator in Computational Biomedicine position! Don't miss the chance to drive cutting-edge AI & big data research in health with us @HelmholtzMunich @CompHealthMuc . Apply now! 🚀 📅 Deadline: Feb 24
🔗 bit.ly/4gwXFrh

🎉 New Year, New Opportunities! 🚀 We're excited to announce that we are recruiting a PI in Computational Biomedicine @CompHealthMuc @HelmholtzMunich . Join us in shaping the future of health. Apply here: bit.ly/4gwXFrh

Excited to launch the @HelmholtzMunich Imputation Server, enabling genotype imputation within the EU and beyond. Lots of plans for future development, reference panels and functionality enhancement rdcu.be/d0h3y

New Resource Alert: Launch of Imputation Server 🧬 #HelmholtzMunich has launched the Helmholtz Munich Imputation Server, offering researchers globally a powerful platform for secure genotype imputation. 👉t1p.de/tut8j 💡Imputation is the statistical inference of unobserved genotypes and plays a pivotal role in genetic analyses. Researchers at #HelmholtzMunich have developed an imputation server to assist users in complying with their GDPR requirements. This EU-based platform offers access to sequence reference panels and to integrated imputation machinery, ensuring secure and efficient research across borders. @EleZeggini @NatureGenet @CompHealthMuc #Genomics #DataPrivacy #Genetics #Data #GDPR

So happy to announce the next Helmholtz Pioneer Campus (HPC) Principal Investigator (f/m/x) recruitment round to promote wonderful young talent in Bioengineering and Biomedicine. nature.com/naturecareers/…

@OzvanBocher @UBO_UnivBrest @GeninEmmanuelle Congratulations!! We will miss you dearly @HelmholtzMunich but we will keep collaborating!

I am thrilled to announce that I will be starting a tenure-track position at @UBO_UnivBrest in November focusing on developing statistical approaches for genetics and multi-omics analyses. Special thanks to @EleZeggini and @GeninEmmanuelle for their constant guidance and support!

Excited to share the latest T2D Global Genomic #T2DGGI. medrxiv.org/content/10.110… Lead by super starts Ravi Mandla, Kim Lorenz, @XianyongYin @OzvanBocher @AliciaChagoya Anna Arruda, Anthony Piron, Susanne Horn, co-supervised with Andrew Morris, @bvoight28 @EleZeggini

The largest genome-wide association study for type 2 diabetes so far, which included several ancestry groups, led to the identification of eight clusters of genetic risk variants go.nature.com/3xzZ27i