Olivier Elemento

Can we program cells like computers — using RNA? Two years ago, our group trained the first language model to decode the regulatory grammar of 5′ UTRs in mRNA, published in Nature Machine Intelligence. Today, we’re excited to share the next step, also in Nature Machine Intelligence: “Programmable RNA translation through deep learning-driven IRES discovery and de novo generation.” We built an AI engine to discover, predict, optimize, and generate IRES elements — RNA control modules that regulate translation initiation. This brings us closer to programmable RNA systems that control when, where, and how strongly proteins are produced inside cells. AI is no longer just helping us read biology. It is beginning to help us write it and harness it. The future of computing may not only run on silicon — it may also run inside living cells. #AIForBiology #LLM #AI4S #AI #RNA #MachineLearning #Bioengineering

Excited to share our RegVelo paper in Cell cell.com/cell/fulltext/… We unify RNA velocity + GRNs into one model → better OOD prediction of perturbations (e.g. gene KOs), with examples incl. neural crest KO predictions 🔬 Big thanks to W Wang, Z Hu & T Sauka-Spengler 🙏

Excited to present the first pre-print from our group, an investigation the human bone marrow microenvironments in patients with myelodysplastic syndromes (MDS) and normal age-matched subjects using Xenium genotype-informed spatial transcriptomics: biorxiv.org/content/10.648…

Register today Thursday's @WCMEnglanderIPM #PrecisionMedicine Research Conference, featuring Drs. Sam Oscar Kleeman (@KleemanSam) from @CSHL and Vered Stearns (@VeredStearns) from Weill Cornell Medicine! #BreastCancer #Biomarkers

The fascinating agenda for our June 1-2 symposium, "#ArtificialIntelligence for #BasicResearch in #Medicine and the #LifeSciences," with @WCMEnglanderIPM Director @ElementoLab & @hajirasouliha, has just been released! #AI Check it out and register today! eipm.weill.cornell.edu/news-events/sy…

Reminder to register for next Thursday's @WCMEnglanderIPM #PrecisionMedicine Research Conference, featuring Drs. Sam Oscar Kleeman (@KleemanSam) from @CSHL and Vered Stearns (@VeredStearns) from Weill Cornell Medicine! #BreastCancer #Biomarkers

🚨 Out today in Cell! @CellCellPress Path2Space: #AI that predicts spatial transcriptomics (ST) from H&E pathology, enabling spatial biomarker discovery in #BreastCancer at scale. 📄 doi.org/10.1016/j.cell… 🧵1/8

1/ Excited to share that TranscriptFormer is now published in Science. We trained a generative foundation model on 112 million cells across 12 species spanning ~1.5 billion years of evolution. science.org/doi/10.1126/sc…

Just scheduled! The next @WCMEnglanderIPM Special Seminar & Ask Me Anything, "Behind the Scenes @Nature," will feature Dr. George Caputa (@curiousdrgeorge) on May 21st live & on zoom!

Register today for the next @WCMEnglanderIPM #PrecisionMedicine Research Conference, featuring Drs. Sam Oscar Kleeman (@KleemanSam) from @CSHL and Vered Stearns (@VeredStearns) from Weill Cornell Medicine! #BreastCancer #Biomarkers

Today in @Nature, the @genophoria & Vijay Ramani labs reveal that our picture of how nucleosomes regulate DNA accessibility has been too simple. They find that over 85% of nucleosomes in mammalian cells are structurally distorted, with DNA partially accessible even while wrapped.

We hope you can join us one week from today for our next @WCMEnglanderIPM #AI Clinic "Leveraging AI for Scientific Research in 2026," presented by Dr. Junbum Kim (@junbum_kim)! Register below:

All-Star panel of experts at today's "#AI to Advance Medicine: From Research to Practice," @WeillCornell with @WCMEnglanderIPM Director Olivier Elemento, PhD (@ElementoLab) @mertrory @vinayiv @feiwang03 @HeartBobH, Adam Cheriff and Bethany Percha!

Register today for tomorrow's #AI to Advance Medicine - Dean's Lecture Series, "AI to Advance Medicine: From Research to Practice," featuring @WCMEnglanderIPM Director Olivier Elemento, PhD (@ElementoLab) and AI leaders from across @WeillCornell! weillcornell.zoom.us/webinar/regist…

Congratulations to our @WCMEnglanderIPM colleague Dr. Iman Hajirasouliha (@hajirasouliha) and @rajsuraj99 on their exciting new @npjDigitalMed paper, "Trial emulation for validating the clinical efficacy of a foundational #AI model in #embryo selection." nature.com/articles/s4174…

Why should we have to choose between the depth of a targeted panel & the breadth of #WES? "EXaCT-2: an augmented and customizable oncology-focused whole exome sequencing platform," by EIPM's @asbonerw @PeterWaltman @ElementoLab Drs. Alonso, Wilkes, et al nature.com/articles/s4169…

New in JES: we performed clinical genome sequencing in 560 adults with metabolic disease (HLD/HTG, T2D, prediabetes, MAFLD/MASH). 6% carried P/LP variants in monogenic metabolic genes, most often APOB and LDLR.

Register now for our next #AI Clinic, "Je m'appelle Claude: Thinking, Prompting, & Building with LLMs," presented by @WCMEnglanderIPM's @AlexSigaras! @claudeai

Reminder: Three weeks from tomorrow is the deadline to register for the @Cornell "Artificial Intelligence (#AI) for Basic Research in #Medicine and the #LifeSciences," Research Symposium in New York City June 1-2! Register today: cognitoforms.com/IPM3/Symposium…

Introducing Claude Opus 4.7, our most capable Opus model yet. It handles long-running tasks with more rigor, follows instructions more precisely, and verifies its own outputs before reporting back. You can hand off your hardest work with less supervision.