Elevia Health

@ChrisMasterjohn @ChrisMasterjohn do the think the mechanism could be: Progesterone ↓ Allopregnanolone ↓ Less GABA inhibition α4 receptor remodeling PLUS Progesterone ↓ Estrogen unopposed More glutamate More calcium entry neuronal excitation

This is true and it is much worse than he says. High-dose progesterone and allopregnanolone are LESS EFFECTIVE AND 🚨MORE DANGEROUS(!!!)🚨 than benzodiazepines. The evidence base is tiny but it is very ugly. In the FDA application for zuranolone, an allopregnanolone analog, one woman developed a seizure the day after she withdrew. This was confounded by kratom use that morning and a subsequent epilepsy diagnosis. But they documented a withdrawal syndrome similar to but less intense than for Xanax. Their own experiments with dogs showed three had convulsions in response to withdrawal, one of whom died spontaneously and one of whom had to be euthanized. Despite this neither brexanolone, a natural allopregnanolone, nor high-dose progesterone are effective against epilepsy, whereas benzodiazepines are a reliable first-line defense against status epilepticus and their rapid in-field injection by paramedics cuts the mortality rate for status epilepticus three-fold. So you have benzo-level withdrawal seizures being documented from among the most nascent evidence base but no benzo-level emergency value. Neurosteroids have all the danger of benzos with not a tenth of the benefit. Dangerous stuff. Referenced and discussed in more detail in the article I dropped yesterday.

@lowmegatron Does this translate to humans?

Low progesterone increases the odds that cows will get pregnant with twins. Progesterone is decreased by the stress of eating the large amounts of feed needed to produce a lot of milk. “Most of the problem has to do with low progesterone levels at the time of ovulation. And that is being driven by the high rate of feed intake high producing cows need to sustain stratospheric levels of milk production. High producing cows will eat well over 50 lb of dry matter per day, and well over 100 lb of feed on an as-fed basis. These high rates of feed intake increase blood flow through the liver, which in turn reduces the amount of progesterone circulating in the blood. Low progesterone, in turn, results in higher rates of double ovulation. Double ovulation does result in higher conception rates, but also more pregnancy losses – and more twins.” And in artificial insemination: “Increasing progesterone before timed artificial insemination may effectively decrease double ovulation and twinning in high-producing multiparous Holstein cows.” A 2021 review summarizing those cattle studies reported that double ovulation was “three-fold greater for low than for high progesterone cows (33% vs. 10%),” with more twin pregnancies in low-progesterone cows. Ref: Effect of manipulating progesterone before timed artificial insemination on reproductive and endocrine outcomes in high-producing multiparous Holstein cows Economics of Twin Pregnancies in Dairy Cattle

@TakeThiamine the issue is that when they remove glyphosate they will use another chemical that is 200x worse

@pikeypilled Anyone actually tried this substance with positive effects?

Average Meldonium baby in Soviet Russia

@MetabolicTonic I noticed a difference in how I felt (more relaxed etc) with the 2023 and prior batches, but nothing with the 2024 and 2025 ones. Just wondering if others had this same experience

@MetabolicTonic do you notice a difference taking the newer ones from 2025?

The only thing I've found so far that makes Progest-E orally tolerable to take (and easy) is to put it on chocolate.

@Romadroy @thehealthb0t Alittle olive oil is ok if you can find a good quality one (most are adulterated with other nut and seed oils -even organic ones). Also it contains 10% linoleic acid. Same with Avocado oil.

@EleviaHealthND @thehealthb0t Yup. Better to stick with a good quality extra virgin olive oil. Cold press coconut oil, or avocado oil

“Things that are normal in America but legal in Russia” “#1: Synthetic Vaccines” “#2: In Russia it’s illegal to sell genetically modified food”

They can: Reduce estrogen signaling (anti-estrogenic in some contexts) Lower prostaglandins, cortisol, NF-κB Increase GABAergic tone (especially apigenin) Reduce excess aromatase activity

Apigenin & fisetin Flavonoids (plant defense compounds) Act mainly by: modifying enzyme activity altering receptor signaling indirectly lowering inflammation and stress signaling

They are sometimes loosely called “progesterone-like” because they can mimic a few downstream effects, not because they are hormones.

Shown in animals to: improve metabolic efficiency reduce inflammatory load support bone and vascular health Mechanisms (very simple) Lowers excessive stress signaling Protects mitochondria from oxidative damage Helps cells recycle properly Reduces inflammatory enzymes

Fisetin (a flavonoid) — explained simply What it is Fisetin is a plant flavonoid found in: Strawberries 🍓 (highest common food source) Apples Persimmons Onions Cucumbers

What it does (main actions) Antioxidant (reduces oxidative stress) Anti-inflammatory Senolytic → helps remove senescent (“aged”) cells Supports mitochondrial function Can lower inflammatory signaling (NF-κB) Why people talk about it Studied in aging and longevity research

Your body isn’t a machine — it’s a process. Health isn’t something you have or lose; it’s something your body does moment by moment. Each moment responds to the past, the environment, and what the body is trying to become. Symptoms aren’t random — they’re responses.

Having a low thyroid can lead to unstable energy that leads to adrenaline Adrenaline can cause: The feeling of wired by tired Panic attacks Vigilance Problems sleeping So anxiety is often: Stress hormones masking a thyroid deficiency “revving up” as the body lacks steady fuel

Low thyroid = narrowed world When thyroid function is low: Body temperature drops Blood sugar becomes unstable Stress hormones rise to compensate The lived experience: Cold hands and feet Fatigue Brain fog Flatness or heaviness Hopeless or anxious thinking

Thyroid governs perception. Not symbolically — literally.

If life feels: Too much Too sharp Too heavy Too fast Don’t ask: “What’s wrong with me?” Ask: “What state is my body in right now?” That question alone is healing.

Why this changes how we approach healing Healing is not: Forcing positive thoughts Pushing productivity “Adapting” to stress Healing is: Restoring energy Restoring safety Restoring bodily trust When the body feels safe, the world opens again.

Someone with chronic stress: Interprets neutral faces as hostile Feels overwhelmed by small tasks Loses creativity and playfulness This isn’t a personality flaw. It’s embodied perception under stress.