Chris Masterjohn

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Chris Masterjohn

Chris Masterjohn

@ChrisMasterjohn

Mitochondrial health expert applying peer-reviewed science to develop evidence-based protocols for human health and longevity. Founder of https://t.co/p1KbY9pqx8.

Katılım Ekim 2009
214 Takip Edilen77.1K Takipçiler
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
Your cells are aging faster than you think. After age 18, mitochondrial density declines by 1% every year—one of the clearest biological markers of aging. By 70, you’ve lost more than half your cellular energy capacity. Here’s what most people miss: this decline isn’t inevitable. 🧵👇
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
@LangleyDonovan AI is tremendously worse than humans at comprehensiveness. Maybe a set of agents could do a meta-analysis with heavily mixing in traditional programming.
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Michael Donovan
Michael Donovan@LangleyDonovan·
@ChrisMasterjohn Seed oils and AI. Chris, I've been following the seed oil debate for some time and gave up the oils 3.5 years ago (ie personally, I'm sold). I noted with interest your comments on Joe Rogan about how we need trials that exceed eight years or so, not simply more short-term trials. Given that's unlikely - it's presumably both very expensive and difficult to strictly control RCTs over that time frame - do you think that AI analysis of all the data and trials that we currently have may be able to tease out at least a probability that seed oils/high PUFAs are the main baddies for health? It would be great if you and your colleagues could get an audience with people like Demis Hassabis (Deepmind) and Dario Amodei (Anthropic) to discuss the likelihood of AI reaching a compelling verdict on both the suggested mechanisms and on the data? (Maybe observational data becomes more compelling if AI can see every twist and turn?) cc @drcateshanahan @ChrisKnobbeMD @DrSuneelDhand
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
@aakashgupta You’re changing my mind in the opposite direction. A bunch of brain regions firing when learning outcomes were the same shows that a bunch of brain regions firing was to control the pen and not to learn the material.
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Aakash Gupta
Aakash Gupta@aakashgupta·
This is a 12-year-old study that has failed replication three times. And the underlying claim is still probably right. The paper is Mueller and Oppenheimer, 2014. 67 students at Princeton. Longhand note-takers scored higher on conceptual questions. Became the most cited paper in every “ban laptops” argument on Earth. Then three separate labs tried to reproduce the result. Urry et al. at Tufts in 2021, 145 students. No effect. Morehead et al. in 2019, two experiments. No effect. A meta-analysis pooling eight similar studies. No effect. So why am I saying it’s still right? Because a 2023 Norwegian EEG study with 256 channels found something the behavioral research couldn’t measure. Handwriting produces theta and alpha connectivity patterns between parietal and central brain regions that typing does not produce. Those specific frequencies are the ones your hippocampus relies on for memory formation. Your brain treats handwriting as a motor-spatial problem. Five brain regions fire in coordination: premotor cortex, parietal cortex, cerebellum, fusiform gyrus, sensorimotor cortex. Typing activates a fraction of that network. The original study measured the right outcome with the wrong methodology. The real finding lives at the neural level: handwriting rewires the encoding process itself.
Brandon Luu, MD@BrandonLuuMD

Students who took notes by hand scored ~28% higher on conceptual questions than laptop note-takers. Writing forces your brain to process and compress ideas instead of copying them.

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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
@Alexleaf If you had hormonally induced increase in fat storage capacity you’d get fatter and it would prevent insulin resistance. So this probably isn’t the cause of insulin resistance but it could be a contributor to healthy body fatness.
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Alex Leaf
Alex Leaf@Alexleaf·
Editor's note: there's no empirical evidence suggesting that "dysfunctional hormones trap fat in storage". In fact, those with obesity and insulin resistance often have leakage from their fat stores into circulation because insulin can't keep it locked away. Maybe there is some wonky condition out there where this is genuinely the case, but that would be an overwhelmingly rare exception to the rule and unapplicable to most people.
Elie Jarrouge, MD@ElieJarrougeMD

Body fat storage is hormonally regulated. Body fat breakdown is hormonally regulated. Yes, the law of thermodynamics still applies. But the calorie model assumes your body can freely access stored energy. In metabolic dysfunction, that’s NOT the case. If your dysfunctional hormones trap fat in storage, your body increases hunger and lowers energy long before it burns that fat even while carrying 100+ pounds of stored energy. That’s not a willpower problem. That’s physiology. But we still tell people to “just eat less and exercise more.” 🤦🏻‍♂️

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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
Fred Kummerow outlived Ancel Keys by two years (102). A critic of Ancel Keys, he liked to tell the story of the time he had dinner with Keys. Keys ordered a steak. Kummerow said “I thought you don’t eat saturated fat?” Keys reportedly said “Oh that’s not for me, that’s for the people.” A lifelong critic of partially hydrogenated oils, he single-handedly got them out of the US food supply in his late 90s by catching FDA on a legal technicality (they failed to respond to his question in six months) and threatened to sue them for it unless they opened the path to rejecting their GRAS status, which happened quickly. I rented a studio apartment in his basement during this time and had lunch with him every Saturday, so I heard the stories about what was happening in the courts on a regular basis. I never estimated his saturated fat intake but he ate eggs and full fat dairy but relatively small amounts of meat, though he still ate meat regularly. One of his quirkiest nutrition habits was to measure the minerals he lost in his urine and adjust his diet and supplements to replace them. Evidently Keys and his enemies are all capable of living long lives.
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
@predict_addict I’ve never been taught or have taught anything like that. Every teacher I saw comment on the issue said * Don’t highlight, take written notes. * Don’t type notes, write them.
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
@meta_boli Yes studies like this are comparing two averages not providing ultimate truth about the best way to study.
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Meta Boli
Meta Boli@meta_boli·
@ChrisMasterjohn The problem when the course is dense then the handwritten notes are too slow (ex math) and writing the notes steals focus from understanding what the class is about. I eventually stopped taking notes and looked up reference material afterwards.
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
This has been well known for decades but it isn’t because writing makes you use your brain. It’s because writing is SLOWER than typing and efficiency and speed are the enemy of understanding. Slowness forces the student to reword what they are writing because they have no time to write down everything and rewording requires thinking about meaning. Typing is fast enough to write down direct quotes so it doesn’t require thinking about meaning. Use efficiency and speed for rote things that free up time to slow down for what you want to derive meaning from.
Brandon Luu, MD@BrandonLuuMD

Students who took notes by hand scored ~28% higher on conceptual questions than laptop note-takers. Writing forces your brain to process and compress ideas instead of copying them.

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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
@AJA_Cortes It’s not common but when I was in grad school my lab mate had to reject a super lean bodybuilder from a quercetin pharmacokinetic bioavailability study because his BMI said he was obese. 😂
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AJAC
AJAC@AJA_Cortes·
Ive made this point for years, BMI is useful and directionally accurate in the vast majority of people The only people who argue about this are fitness brotards who want to humble brag about their (self estimated) bodyfat% and weight
Crémieux@cremieuxrecueil

There are a few people for whom BMI doesn't indicate obesity. Very few. Comparing BMI to body fat-based assessments, there's >98% agreement, with 97% for men and 99.9% for women. BMI works well at the population level!

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Alan Aragon
Alan Aragon@TheAlanAragon·
@ChrisMasterjohn Two posts ago (with emphasis) for you to re-read since you’re missing the point and veering into tangents. Gotta work now, have fun Berg-ing, Chris.
Alan Aragon tweet media
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Alan Aragon
Alan Aragon@TheAlanAragon·
Few problems: 1) Sodium losses during sleep are negligible, water losses (mainly via respiration) are substantial. 2) The general public overconsumes sodium and underconsumes water. 3) Breakfast is more than enough to meet any urgent sodium need (which is unlikely to begin with).
Dr. Eric Berg@dr_ericberg

Drinking just water in the morning, when blood volume is lowest, may dilute electrolytes and increase dehydration. Adding a pinch of sea salt can help retain water in the bloodstream and improve how you feel.

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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
It would need to be at least 5 times saltier than home food to rival total processed foods, and the average restaurant meal has plenty of processed foods. In order for this to stay relevant to the conversation, you'd have to defend the claim that, for example, someone who eats out and tries to eat Eric Berg's rules for eating out, be they low carb or seed oil free or paleoish or whatever, is getting 5 times more salt than if they made that food at home. I don't think you could support that but that would still only defend the claim that a Bergian eater who doesn't make home cooked meals often is still eating high salt but it would not defend the quantitative importance of a small amount added to water, which is small in one case or the other.
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Alan Aragon
Alan Aragon@TheAlanAragon·
@ChrisMasterjohn If you need a study showing that meals eaten out are saltier than meals prepared at home, that’s pretty hilarious, Chris. PMID: 28235618
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
In studies that describe "outside the home" they pool restaurant and processed foods together. 5.1% of salt intake is added during cooking and 6.2% is added at the table, whereas 77% is added during the processing of processed foods. That leads me to think about 10% is going to come from whole-food-based meals regardless of whether they are eaten out or at home, whereas processed foods will be the overwhelming determinant in either case. So someone who avoids processed foods has dramatically less salt intake than someone who doesn't and someone who adds an extra pinch to their water is adding very little. If you know of a study showing that salt added to cooking at a restaurant dramatically exceeds the same meals cooked at home please post it.
Chris Masterjohn tweet mediaChris Masterjohn tweet mediaChris Masterjohn tweet media
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Alan Aragon
Alan Aragon@TheAlanAragon·
@ChrisMasterjohn Overconsumption of sodium is likely if you live in the developed world & regularly eat meals out (ie, the gen pop). None of our audiences are predominantly competitive athletes. Also, my post was elucidating a falsely claimed ‘need’ rather than a health threat.
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
The point is that the tool you are using cannot tell if you are training it at 70-100% intensity, and the idea that you need to train it at exactly 100% intensity to train it has zero merit. So you can measure all you want but your precision is fake because you could be "missing" it but training it at 85% intensity, and to say you can't get nearly all the results from doing that makes no sense. Then the question is whether you are testing lactate with finger prick, continuous monitor (not available in US), or catheter venous draw (exercise science lab, expensive). If you are finger pricking lactate during the exercise this is a serious detraction from actually doing the exercise and I seriously doubt even a well constructed dataset has value for the average person that exceeds what is lost from focusing on the exercise. If you are doing it at a lab and paying for it, cool, but quite expensive and time consuming to get a serious dataset across multiple types of exercise and multiple intensities, and still questionable whether you're getting insights precise enough to outweigh the expense of both time and money instead of putting that focus into training. Then the question is how all this would perform against deciding to do some exercise at each of the perceptible differences in intensities, monitor results, and adjust proportions spent on each according to what gets the most results across the board.
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James DiNicolantonio
James DiNicolantonio@drjamesdinic·
Chris your response actually proves my point that lactate threshold has merit. It highlights the point to where you have fully stressed the slow-twitch fiber's ability to use lactate as a fuel, leading to increasing lactate in the blood. And hence, why training at this threshold will improve this capacity, boost mitochondrial density in slow-twitch fibers, upregulating MCT-1, enhancing lactate oxidation, and shifting the threshold higher (so you can sustain harder efforts longer without big lactate buildup). If you aren't measuring lactate, how would you ever know if you are hitting this threshold for adaptation?
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
All the research I have read on "zones" has led me to this conclusion. There are many ways of measuring the zones, and none of them predict with single-zone precision any of the others. The precision of binary zone definition is false, but the continuum of intensity is real.
Steve Magness@stevemagness

There are no magical training paces! VO2max, Lactate Threshold, Critical Velocity, etc. None of them are special. They all have their purpose. Think of training as a spectrum– from jogging to sprinting–not as zones. All paces are useful and at your disposal.

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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
First, the various definition of lactate thresholds, aerobic and anaerobic thresholds, and lactate-based zone definitions, are all different from one another but overlapping and cannot be used to precisely predict one another just like the various zones of training can’t predict one another. Second, the glycolysis system is induced way under the point at which lactate accumulates in the blood. The slow twitch fibers clearing the lactate from the fast twitch fibers will keep the blood lactate signal relatively silent, yet they are being trained to oxidize the lactate (using aerobic respiration not glycolysis). As that moves to reliance on the liver in the Cori cycle the blood lactate appreciates but that’s the point at which the slow twitch fibers are having their capacity exceeded. You could oversimplify this to say that this is the point in which the Cori cycle “turns on,” but if it’s barely being used it isn’t being heavily trained. Meanwhile, the fast to slow twitch shuttle and oxidizing capacity of the slow twitch mitochondria got maxed out right before the blood lactate signal “lit up.” So at that point your lactate system being trained is that shuttle/oxidizing capacity, but when there’s no signal you could be training it at 90% intensity or 80% intensity and as the signal lights up and increases you aren’t even changing the intensity of that system because you’re going from 100% to 100%. None of this indicates that the physiological parameters are meaningless. But, it does question whether having no signal at 95% training intensity for the fast to slow twitch shuttle system versus a big signal at 100% is telling you something binary, or anything relevant to your training with practically useful precision. Further the idea that this says something about glycolysis turning on is definitely wrong, as the point at which glycolysis turns on is way below the point at which a blood signal can be seen.
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Steve Magness
Steve Magness@stevemagness·
@drjamesdinic @ChrisMasterjohn I don’t know what you’re arguing. The lactate threshold has little to do with “glycolotyic” system. LT training is just high end aerobic training. It’s great. But you can develop that through multiple paths. Some well below LT. Some right below. Some above. Some well above.
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Cernovich
Cernovich@Cernovich·
The current politics on Iran: My clique - benefit of the doubt, not naive, tired of the slop, but will go along with it for a bit. Boomers - love war, this is entertainment for them. First-time voters who delivered Trump the popular vote: GUTTED.
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
Another thing that’s not a joke: The EBM pyramid was not invented by a doctor, trialist, statistician, scientist, or scholar. It was invented by the html specialist at the SUNY Downstste library, Martin Mellish, in 1996. It was never endorsed by Sackett, Guyatt, or any other leaders of EBM. It has never appeared in Guyatt’s EBM textbook. The GRADE Handbook has no pyramid anywhere in its entirety. It’s been propagated by lazy educators who know little about EBM and do google image searches for it to add it to their Powerpoint presentations. Guyatt told me it is “totally confused.” Among its problems are it melts together multiple different hierarchies. For example systematic reviews are not above RCTs. You can have a systematic review of cell studies and it being a systematic review doesn’t put it above RCTs. It also is completely biased by treatment effects. If you want to ask a question about prognosis you don’t need to randomize and the most important thing is the length of study matches the time horizon of your research question. If you want to know how many stars are in the sky, a randomized controlled trial is not superior to an observational study. The pyramid is indeed “totally confused.”
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Chris Masterjohn
Chris Masterjohn@ChrisMasterjohn·
@AbudBakri What’s not a joke is that Gordon Guyatt, the Father of Evidence-Based Medicine, has always put randomized n=1 self-experiments above multi-patient RCTs for decades, including in the most authoritative EBM textbook, as it remains in the most recent edition.
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Abud Bakri MD
Abud Bakri MD@AbudBakri·
“Do you have a study that proves it?” No, its consensus amongst bodybuilders, which is a time warp into studies that will be published 1-2 decades from now (This is a joke of course)
Abud Bakri MD tweet media
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