Elixir Medical Corp

Breaking Down Calcium with Precision LithiX HC-IVL is designed to address the full spectrum of complex calcium morphologies, including nodular, eccentric, and concentric calcium — even in long and tortuous lesions. LithiX’s ability to create controlled fractures in calcium with a single device helps simplify lesion preparation and facilitate optimal stent expansion in PCI. Watch the LithiX mechanism of action: youtu.be/UlakE3L4TYY?si… #LithiX #CalciumModification #IVL #PCI The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States. PMN 2429 Rev A

When and Why to Consider a Bioadaptor in PCI Planning Choosing the right PCI device can make a significant difference in long-term vessel health. When planning PCI, the DynamX bioadaptor provides an option that supports a return to natural vessel function. Studies have shown it may help reduce the risk of long-term adverse events associated with DES implants. Consider DynamX bioadaptor for: ·LAD lesions ·Younger patients ·Active patients ·Primary PCI Visit our Clinical Evidence page to learn more: elixirmedical.com/ous/clinical-e… #PCI #bioadaptor #DynamX #VesselRestoration The DynamX® Coronary Bioadaptor System is CE mark approved and is not available for sale in the United States. Caution: The DynamX Sirolimus Eluting Coronary Bioadaptor System is an investigational device in the United States. Limited by Federal (or United States) law to investigational use. PMN 2430 Rev A

We’re heading to Paris for #EuroPCR2026, May 19-22. The global interventional cardiology community will come together in just two weeks! Join us in sharing new data, exchanging ideas, and advancing the future of PCI. We’re excited to hear from leading physicians presenting new clinical study results and real-world insights on bioadaptor technology, intravascular lithotripsy advances, and site-specific therapy. Stay tuned for more on our sessions and symposia. #EuroPCR #ElixirMedical #Cardiology #PCI #Medtech #Innovation PMN 2470 Rev A

Join us at @TurinCTO_CHIP Live 2026 📅 May 6–8, 2026 📍 Turin, Italy Elixir Medical will be featured across multiple hands-on and live case sessions, including: 🔹 HANDS-ON: CTO Calcium & Imaging Corner (Session 1 & 2) 📅 May 6 | Hall 150 |15:15-16:30 & 18:15-19:30 Two interactive sessions within the NEXT GEN program, providing practical experience in imaging and calcium modification techniques in CTO procedures 🔹 Bioadaptor& LithiX Case (Live Case 3) 📅 May 7 | Auditorium | 11:35-13:30 Real-time insights into PCI strategy and vessel restoration using #DynamX #Bioadaptor and LithiX™ Hertz Contact IVL technologies in complex anatomy Operators: @AriotiManfredi & @RobertoGarbo1 🔹 LithiX Case A case demonstration highlighting the role of LithiX™ Hertz Contact IVL in producing a multitude of visible cracks and maximizing stent expansion during complex PCI in lesions with eccentric, concentric or nodular calcium¹ We look forward to contributing to the exchange of techniques and real-world experience in CTO and CHIP interventions. #TurinCTOCHIP #PCI #CTO #CHIP #Bioadaptor #DynamX #LithiX #HCIVL #Cardiology #ElixirMedical 1. S. Verheye et. al. PINNACLE l EuroIntervention2026;22:255-264 The LithiX HC-IVL system and the DynamX® Coronary Bioadaptor System are CE mark approved and are not available for sale in the United States. Caution: The DynamX® Sirolimus Eluting Coronary Bioadaptor System is an investigational device in the United States. Limited by Federal (or United States) law to investigational use. PMN 2468 Rev A

Are you looking for the next evolution of vascular intervention? Take a deep dive into the DynamX® Coronary Bioadaptor System. Visit our new LinkedIn showcase page for an in-depth look at the device’s functionality and proven clinical results. We’ll be updating the page often with product announcements, clinical study results, case studies, and testimonials from physicians who have utilized DynamX in their PCI cases. linkedin.com/showcase/dynam… #ElixirMedical #DynamX #Bioadaptor #VascularIntervention #CoronaryArteryDisease PMN 2437 Rev A The DynamX® Coronary Bioadaptor System is CE mark approved and is not available for sale in the United States. Caution: The DynamX® Sirolimus Eluting Coronary Bioadaptor System is an investigational device in the United States. Limited by Federal (or United States) law to investigational use.

Elixir Medical has launched a new LinkedIn showcase page for the LithiX™ Hertz Contact Intravascular Lithotripsy (HC-IVL) Catheter. This page offers more details and regular updates on the novel intravascular lithotripsy device, providing accessible and at-a-glance information for physicians looking for new innovations in coronary calcium treatment. Visit the LithiX page for clinical evidence results, case studies, expert insights, and more: linkedin.com/showcase/lithi… #ElixirMedical #LithiX #IntravascularDevice #CoronaryCalciumTreatment PMN 2436 Rev A Caution: The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States.

What Physicians Are Saying About LithiX As physicians gain hands-on experience with LithiX™ Hertz Contact IVL, they’re seeing how LithiX supports efficient workflows and successful PCI results in real-world practice. Watch a video as a panel presents some early LithiX cases: youtu.be/YoC6YNX-H2c?t=… #LithiX #PhysicianVoices #PCI #CalciumModification The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States. PMN 2433 Rev A

Join us at Danube CHIP & CTO 2026 📅 April 23–24, 2026 📍Vienna, Austria Elixir Medical will be presenting during the scientific program: 🕑 14:00–14:22 “Streamlining Severe Calcium Modification with LithiX IVL” Speaker: @JohanBennett2 This presentation will explore approaches to simplifying severe calcium modification in complex PCI using #LithiX #HCIVL. We look forward to contributing to the discussion on advancing treatment strategies in challenging anatomy. #DanubeCTO #PCI #LithiX #IVL #CalciumModification #Cardiology #ElixirMedical The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States. PMN 2457

Complex lesions. Confirmed adaptive remodeling. The investigator-initiated DYNAMITE Study, now published in The American Journal of Cardiology, evaluated DynamX exclusively in challenging anatomy — long lesions, CTOs, bifurcations, and multi-device cases. At 9 months, positive vessel remodeling was confirmed by two independent intravascular imaging modalities. See the data: sciencedirect.com/science/articl… #DynamX #Bioadaptor #PCI #InterventionalCardiology #ClinicalEvidence #IRCCSHumanitasResearchHospital The DynamX® Coronary Bioadaptor System is CE mark approved and is not available for sale in the United States. Caution: The DynamX® Sirolimus Eluting Coronary Bioadaptor System is an investigational device in the United States. Limited by Federal (or United States) law to investigational use. PMN 2455 Rev A

Join us at the DGK Annual Meeting 2026. 📅 April 9, 2026 📍 Congress Center Rosengarten Rosengartenplatz 2 - 68161Mannheim Elixir Medical will participate in two focused sessions addressing challenges in contemporary PCI, featuring #LithiX #IVL and bioadaptive angioplasty with #DynamX Coronary Bioadaptor System. 🔹 Session 1 NEW APPROACHES TO OPTIMIZING PCI RESULTS 13:00 – 14:30 Room 15 Faculty: @GaedeLuise & @tommasoggori , Maren Weferling, @HolgerNef, @NikosWerner, Christoph Liebetrau 🔹 Session 2 Bioadaptor live-in-the-box case: Bifurcation – PCI 08:00 – 09:30 Room 22 Operator: Alexander Ghanem Join to learn how our versatile #LithiX #IVL optimizes stent expansion regardless of calcium morphology¹ and how #Bioadaptor significantly reduces TLF rate compared to #PCI Standard of care². These sessions will bring together innovative technologies, clinical evidence, and real-world insights to support decision-making in complex coronary interventions. #DGK2026 #PCI #Cardiology #ElixirMedical #LithiX #IVL #DynamX #Bioadaptor 1. S. Verheye et. al. PINNACLE l EuroIntervention 2026;22:255-264 2. D. Elinge et. aL. INFINITY-Swedeheart 12 months. The Lancet 2024 The LithiX™ HC-IVL system and the DynamX® Coronary Bioadaptor System are CE mark approved and are not available for sale in the United States. The DynamX® Coronary Bioadaptor System is CE mark approved and is not available for sale in the United States. Caution: The DynamX® Sirolimus Eluting Coronary Bioadaptor System is an investigational device in the United States. Limited by Federal (or United States) law to investigational use. PMN 2420 Rev A

Join us at the @German_CTOCHIP meeting for a live case with operators Mohamed Ayoub & Masahisa Yamane. 📅 March 28, 2026 🕘 08.30 am 📍 NORD EVENT Panoramadeck Emporio, Dammtorwall 15, 20355 Hamburg, Germany Live Case #8: Protected PCI in CHIP post-CABG During this live case, operators will demonstrate advanced PCI techniques in a high-risk, post-CABG patient, including the use of #LithiX Hertz Contact Intravascular Lithotripsy for calcium modification. #LithiX #IVL can be used in lesions with eccentric, concentric, and nodular calcium, producing a multitude of visible cracks.¹ #GermanCTOCHIP #PCI #CHIP #ComplexPCI #InterventionalCardiology #ElixirMedical #IVL The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States. 1. S. Verheye et. al. PINNACLE l EuroIntervention2026;22:255-264 PMN 2418 Rev A

Join us at the Milano Calcium Course for a live case performed by Giuseppe Sangiorgi & @daniab86 📅 March 26, 2026 📍 Milan, Italy 🕒 15:00 – 16:00 Live 3 | Policlinico Tor Vergata – Rome This live case session will explore strategies for treating complex coronary calcification with versatile PCI techniques, including #LithiX #IVL. #LithiX Hertz Contact Intravascular Lithotripsy (HC-IVL) creates deep, wide cracks in lesions with eccentric, concentric, or nodular calcium without damaging soft tissue.¹ #MilanoCalciumCourse #PCI #Cardiology #CoronaryCalcification #ElixirMedical #LithiX #IVL The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States. 1. S. Verheye et. al. PINNACLE l EuroIntervention2026;22:255-264 PMN 2416 Rev A

Join us at #CathlabOfTheFuture 2026 Maximizing Outcomes in Heavily Calcified LAD: Breaking Through with Novel Techniques 📍 Portoroz, Slovenia | March 6–7 🗓️ March 6 | 13:30–14:30 Scientific Symposium sponsored by Elixir Medical Moderator: @MohanedEgred Faculty: Irzal Hadzibegovic, @DamianoRegazzo1, Maximilian Will This session will explore innovative strategies for PCI. Speakers will be discussing the importance of vessel function restoration to improve PCI outcomes as well as how to optimize stent expansion regardless of calcium morphology with #LithiX #IVL. #PCI #Bioadaptor #LithiX #IVL #Cardiology The DynamX® Coronary Bioadaptor System is CE mark approved and is not available for sale in the United States. Caution: The DynamX® Sirolimus Eluting Coronary Bioadaptor System is an investigational device in the United States. Limited by Federal (or United States) law to investigational use. The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States. PMN 2410 Rev A

Join us at #Euro4C 2026 for a symposium on the role of LithiX Hertz Contact IVL in calcium fragmentation. The session will highlight the mechanism of action for LithiX Hertz Contact IVL, the clinical evidence and real-world case discussions of calcium modification in PCI. Faculty: @HontonB , @JEscaned , @enrico_cerrato , @HawranekMichal , @valeriaparadies 📅 Friday, 27 February 2026 🕓 16:00–17:00 | Main Room, Session ID 41390 #Euro4C2026 #LithiX #IVL #PCI #CalciumModification The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States. PMN 2397 Rev A

Join us at DEBS 2026 in Rome, Italy 📅 February 19–20, 2026 Elixir Medical is pleased to participate in this year’s DEBS program with presentations focused on calcium modification and Bioadaptor vs. DCB strategies. 🔹 Live Case: Calcium Modification with LithiX Operator: @BenedittoDi 🔹 Session 15: Innovation Corner: Bioadaptor vs DCB Featuring: G.M. Sangiorgi We look forward to contributing to the discussion on next-generation coronary therapies. PMN 2392 Rev A #DEBS2026 #LithiX #Bioadaptor #IVL #PCI #Cardiology #ElixirMedical

ICYMI: At TCT 2025, Dr. David Erlinge presented new real-world comparative data on PCI outcomes using bioadaptors vs drug-coated balloons (DCB) for de novo coronary lesions. Using propensity score-matched data from the SCAAR registry, this 2-year analysis included a clinically complex population with >70% ACS patients in both treatment arms. “In this study, the bioadaptor was associated with a better 2-year outcome compared to DCB.” – Dr. David Erlinge Primary composite outcome (target segment revascularization, TV-MI, or all-cause mortality): – Bioadaptor: 4.9% – DCB: 9.7% View the full presentation: bit.ly/4kp4HRR The DynamX® Coronary Bioadaptor System is CE mark approved and is not available for sale in the United States. Caution: The DynamX® Sirolimus Eluting Coronary Bioadaptor System is an investigational device in the United States. Limited by Federal (or United States) law to investigational use. PMN 2315 Rev A

Elixir Medical is committed to transforming the care of patients with heart disease, and today we’re rocking red to help raise awareness of the No.1 killer of women – cardiovascular disease. Visit bit.ly/3L75rch to learn more about heart disease and stroke in women and find more ways to support the @American_Heart's initiative. #WearRedDay #americanheartassociation #HeartMonth NPMC 333

How do we overcome the challenge of calcium modification? At GRCI2025, Frédéric Bouisset, Charlotte Trouillet, Pierre Robert, and Benoît Lattuca shared their experiences with LithiX HC-IVL. They discussed the importance of calcium modification in clinical outcomes and detailed the versatility, deliverability, and safety of LithiX as it was used to achieve outstanding results in lesion preparation in two illustrative cases: • A severely calcified lesion with nodular calcium • A long, eccentric, heavy calcified lesion Check out the full recording to see the OCT and IVUS results for yourself! Watch here: youtube.com/watch?v=YoC6YN… #LithiX #Lithotripsy #GRCI2025 #PCI #ElixirMedical The LithiX™ HC-IVL system is CE mark approved and is not available for sale in the United States. CAUTION: Case studies shown are based on individual experiences and results may vary. Results depend on a variety of factors, including patient history, severity of condition, and compliance with instructions. Elixir Medical does not claim that these results demonstrate the safety and effectiveness of the device. PMN 2381 Rev A

Looking forward to this international webinar hosted by InCathLabon February 3, featuring techniques with our novel LithiXHertz Contact IVL. Clinical insights and real-world cases will highlight how this technology fractures calcium and improves vessel compliance. Register and Join us: incathlab.com/en/lives/19-ca… Speakers: @MohanedEgred, @sinning_jan, @JohanBennett2,@charlottetroui2, @MarcoPavani01 & @OjedaOjeda18 #LithiX #IVL #PCI #CalciumModification #Webinar The LithiX™ HC-IVL system is CE Mark approved and not available for sale in the United States.

What a standout case presented by Dr. Marta Bujak (with Dr. Paweł Gąsior) during the “Novel Solutions for CHIP” session at TCT 2025. This complex case focused on a severely calcified and significantly stenosed LAD, where LithiX HC-IVL was used following IVUS-HD and OCT-guided lesion assessment. Imaging revealed thick, concentric calcium with a calcified nodule and >270° arc. Following LithiX delivery and stepwise inflation, both IVUS and OCT confirmed deep and surface-level calcium fractures. A single balloon effectively prepared the lesion, enabling optimal stent expansion and full apposition with no residual stenosis. This case highlights the clinical potential of LithiX in modifying complex calcium, with clear visualization of its effect using dual-modality imaging. See the case presentation: elixirmedical.com/ous/case-studi… #TCT2025 #LithiX #IVL #CalciumModification #Lithotripsy #PCI #ElixirMedical LithiX Hertz Contact Lithotripsy System is CE Mark approved and not for sale in the U.S.