Feyza Engin

🇳🇬💥 Victor Osimhen (26) with a FANTASTIC winning goal for Galatasaray. It was in the 92nd minute too! 🔴🟡

We extend our sincere gratitude to our outstanding collaborator, Sushmita Roy, her team, the reviewers, and the editor. Congratulations to all authors!

Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1. nature.com/articles/s4146…

@SoleimanpourLab @vaibhavsidarala @marshallu Congratulations Vaibhav 🎯Wishing you the best!

Yesterday we wished @vaibhavsidarala a warm farewell as he heads off to start his lab at @marshallu! Thrilled to see him take the helm and excited for the advances his group will make to treat diabetes. Can't thank him enough for what he did for us! Go Vaibhav! 🤩🥹 #proudPI

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy | Nature nature.com/articles/s4158…

Hat-trick ⚽️⚽️ ⚽️ Three POTM awards in a row 🏆🏆🏆 Victor Osimhen 👏👏👏 #UCL

Galatasaray beat the English champions. #UCL

Our new report with #YaChiHuang ⁦#MarjanRupnik using high-speed imaging in pancreatic slices. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells | bioRxiv biorxiv.org/content/10.110…

@gparlakgul @apsarruda @BerkeleyMetBio Congratulations Ana!🎉🎉🎉

So proud of Ana @apsarruda , my partner in life and in science, for this incredible achievement! Well deserved! 👏🥳 @BerkeleyMetBio pew.org/en/about/news-…

We are hiring! I am recruiting a postdoctoral fellow to join us studying cell stress responses and organelle communication in pancreatic beta cells. Cell and molecular biology background is highly desired. Interested? please contact me at fengin@wisc.edu. hr.wisc.edu/postdoc-and-re…

@EmKSims @T1D_TrialNet Congratulations, Emily and team! 🌟🌟🌟

Super excited this paper on islet autoantibody positive adults is finally online- we analyzed screening and #T1D progression in 100K adult relatives screened as part of @T1D_TrialNet . Available at: bit.ly/4md4scn

@vatsanraman Congratulations Vatsan and team!

Excited to share our new work—PhageMaP, a high-throughput platform for genome-wide knockout screening in diverse phages across multiple hosts. PhageMap reveals essential, non-essential and conditionally-essential genes, interactors with host anti-phage defenses & enables rational phage design. Fun collab with Charlie Mo, exceptional work by Jackie Chen! 📝 Cell Host & Microbe: doi.org/10.1016/j.chom…

Mitochondrial origins of the pressure to sleep | Nature nature.com/articles/s4158…

Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication: Cell Metabolism cell.com/cell-metabolis…

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science science.org/doi/10.1126/sc…

Wow, fatty acid oxidation in neurons! Time to update the textbooks?!

If this is strictly true then it will devastate discovery science in fields like endocrinology and metabolism where there are no meaningful substitutes for physiological studies in whole mammals that can genetically modified in a tissue specific and temporally controlled manner

@ghotamis Congratulations hocam. Wonderful news 🧿🧿🧿

Yuzyilin beyin cerrahi, cok degerli bilim insani ve egitmen Prof. Dr. Gazi Yasargili kaybetmenin uzuntusunu yasiyorum. Saygi ve rahmetle…

@ghotamis @RenataG81952725 Congratulations to all! Very nice study 🧿

Excited to share our latest paper led by Renata Goncalves @RenataG81952725: CoQ imbalance drives reverse electron transport to disrupt liver metabolism. nature.com/articles/s4158… We uncover how altered CoQ redox balance triggers RET and rewires hepatic metabolism to offer critical insights into a decades old question. Meticulously mapping each one of the 11 sites of the mitochondrial electron transport chain in the liver showed site IQ as the sole source of excess mitochondrial ROS, produced via reverse electron transport. This defect is driven by CoQ imbalance in obesity, disrupts glucose metabolism. These findings may have implications for many diseases and open up new treatment possibilities where broad antioxidants have failed to generate therapeutic benefit. Our findings may also offer a potential mechanism and solution for the increased diabetes risk seen in a small fraction of statin users. Huge congratulations to Renata Goncalves @RenataG81952725 for leading this work and for her immense dedication and patience to bring it to a conclusion. Congratulations to all contributors from the @hotamisligil lab and our amazing collaborators Isabel Graupera @igraupe and Shawn Burgess @Isotopomer Curious? The 93-page-long peer review file is full of useful information and insightful discussions.