Federica Eduati

In summary, SPoTLIghT is a great tool for mapping the tumor microenvironment from H&E slides, paving the way for new spatial biomarkers with the potential to improve patient outcome predictions. Huge thanks to first authors @LapuenteSantana & Joan Kant for their work! 🧵 8/8

SPoTLIghT is open-source and available on GitHub for other researchers to explore and expand. Check it out here: github.com/SysBioOncology… #OpenScience 🧵 7/8

Excited to share our latest work on SPoTLIghT, a computational tool for analyzing the spatial architecture of the tumor microenvironment (TME) from histopathology images. #CancerResearch #Oncology #PrecisionOncology rdcu.be/dZujx @TUeindhoven 🧵 1/8

This week in #MathOnco 292: > Project Optimus, radiotherapy, mutation accumulation, and deep learning / AI.... Art: @Maisaavg & @FEduati 💯😎 Signup: mathematical-oncology.org/newsletter

Understanding these complex interactions within the TME through computational modeling could pave the way for novel therapeutic strategies targeting the TME to combat CRPC. Read the paper rdcu.be/dzc1d. @TUeindhoven @NKI_nl

4/5 Additionally, ADT has immunomodulatory effects on the TME, impacting macrophage-mediated tumor cell killing.

1/5 Now published @Nature_NPJ our paper leveraging multicellular computational modeling to study the effect of androgen deprivation therapy (ADT) on the prostate tumor microenvironment (TME). Great work of @Maisaavg @anniek_zaalberg @JJPKneppers with @zwartlab and BergmanLab

Check out our latest work showing how heterogeneity in the TME is functionally associated with immune response. Great collaboration with @Francesca_Fin_ group, check her thread for more info

@CRC_AACR @TUeindhoven @NKI_nl with @zwartlab and Bergman's lab. Many thanks to all authors!

Our paper on modelling the prostate cancer #tumordevelopment is now published in @CRC_AACR !!! @TUeindhoven @NKI_nl #CancerResearch #prostatecancer #systemsbiology

📢#PhD and #PostDoc positions in my group at @uniinnsbruck @DiSC_uibk to computationally reconstruct cancer interactomes from NGS multiomics @FWF_at project in collaboration with @LabiLab5 @villunger @_JoelRiley euraxess.ec.europa.eu/jobs/75233 euraxess.ec.europa.eu/jobs/75236 Please RT! 🙏

Check out the bioRxiv preprint to learn more: biorxiv.org/content/10.110… #tumordevelopment #microenvironment #prostatecancer Thanks to all co-authors for their hard work and dedication.

8/8: Our study sheds light on the complex and multifactorial nature of PCa development, and highlights the importance of understanding the role of the tumor microenvironment in tumor initiation and progression.

1/8: In our new work with @zwartlab and Bergman's lab @NKI_nl, Margot Passier led the development of an agent-based model of a prostatic acinus to study prostate cancer (PCa) development in silico. #prostatecancer #cancerresearch @TUeindhoven