Jeffrey West

Our "evolutionary antifragile therapy" paper is now posted online (Cancer Research): aacrjournals.org/cancerres/arti… First experimental validation of antifragility in cancer (ALK inhibitors in lung)! An awesome collaboration involving @ara_anderson, @AndriyMarusyk, @Binadesai14 et al

@nntaleb, your ideas at work in experimental settings. Next up, clinical translation...

Our "evolutionary antifragile therapy" paper is now posted online (Cancer Research): aacrjournals.org/cancerres/arti… First experimental validation of antifragility in cancer (ALK inhibitors in lung)! An awesome collaboration involving @ara_anderson, @AndriyMarusyk, @Binadesai14 et al

We think of antifragile therapy as a class of "evolutionary therapy" and that it represents a path forward for designing adaptive dosing protocols in the future.

Switching between continuous and varied dosing (intermittent) represents the best of both worlds: kill tumor, avoid resistance.

After his dad passed from cancer in March, Raddy wanted to turn his grief into good 💙 Now, with the proceeds from his Bald Eagle t-shirt and plush in hand, he soared into @MoffittNews to visit with patients and staff!

today, Darren Raddysh donated $20,000 to Moffitt Cancer Center … this money comes from the sale of the bald eagle T-shirts and stuffed animals his why — his dad, Dwayne, who passed away from cancer in March

.@fpradelli94 & I found a compelling candidate for the first published mathematical model in oncology: Hutchinson's 1886 proposal of Malthusian growth law for tumors. The 2nd math onco? A rebuttal of the 1st, a mere ~3 months later. [some things never change]

Optimization of sequential therapies to maximize extinction of resistant bacteria through collateral sensitivity journals.aps.org/pre/abstract/1…

"Universal principles of cell population growth follow from local contact inhibition." We just published an integrative experimental-mathematical approach to defining growth laws in the context of cell-cell interactions: sciencedirect.com/science/articl…

@MoffittNews @fpradelli94 Franco is an awesome addition to Moffitt's @mathonco department! He has experience in computational models of evolution of drug resistance and in constructing Artificial Intelligence pipelines for bibliometric science of science.

#FollowFriday Meet Franco Pradelli, PhD (@fpradelli94), a postdoctoral fellow in Moffitt Cancer Center’s Integrated Mathematical Oncology Department. Working with Jeffrey West, PhD (@mathoncbro), his research uses mathematical modeling to study therapy response and resistance in anaplastic large cell lymphoma. #MoffittAmbassadors

"SpaceBar" by @GrantKinsler

In the Data and AI strengths session, Moffitt’s Noemi Andor, PhD (@EinsteinCross), presents “CLONEID: From Longitudinal Cancer Data to Autonomous Mechanistic Modeling,” exploring how event-based modeling can reproduce longitudinal tumor behavior and inform clone-level decision-making under auditable assumptions.

At #MoffittScientificSymposium, Franco Pradelli, PhD (@fpradelli94), discusses mathematical and experimental approaches to characterizing dose-response evolution in anaplastic large cell lymphoma. Future work will focus on evolutionary-informed strategies to optimize targeted therapies.