Francesco Naso

Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive. One of the immune system’s marvels is its ability to identify pathogens and differentiate them from the body’s own cells. The microbes that threaten our health do not wear a uniform – they all have different appearances. Many have also developed similarities to human cells, as a form of camouflage. So how does the immune system keep track of what to attack and what to protect? Why doesn’t the immune system attack our bodies more frequently? Researchers long believed they knew the answer to these questions: that immune cells mature through a process called central immune tolerance (see image). However, our immune system turned out to be more complex than they believed. Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their discoveries concerning peripheral immune tolerance.

In addition, looking at the roles of the NDP52 variants in pathogenesis rdcu.be/ekxEW

Don't miss the second part of the story! The role of the NDP52 GE variant in Alzheimer's disease:

"It is not the strongest of the species that survives, not the most intelligent that survives. It is the one that is the most adaptable to change." C.Darwin

@peppe_naso Che non era lupo!😂

100 years ago the "serum run" procured diphtheria anti-toxin to Nome, in Alaska. In 2023 a study investigated the genome of Balto, the most famous sled dog involved in the run, revealing its ancestry.

Thanks so much for this experience!

@Rotelli_MD In effetti sarebbe un'idea innovativa se fossimo nel 1795.

"E se invece di farci un vaccino fossimo semplicemente in grado di essere esposti a una versione indebolita del virus che ci permettesse di sviluppare gli anticorpi per combattere il virus stesso?" ... i novax sono così avanti che hanno fatto il giro e hanno inventato i vaccini.

@Rotelli_MD 😂😂😂"Idrogenata"😂😂😂

Non so veramente da dove iniziare a smontare tutte le m...ate che han scritto. Di certo si meriterebbero una denuncia per circonvenzione di incapaci.

Check the program of 2024 WIA Annual Symposium and don't miss Anna's talk!😁

Nobel prize very well deserved and for a topic that we like 😇 @F_Nas0 @kre_br @GioLollo

This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms. Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: bit.ly/4dlPE6f #NobelPrize

In two new Science studies, researchers provide mechanistic insights into micronuclei collapse and the consequences of this process for #cancer. Learn more ⬇️ 📄: scim.ag/8eU 📄: scim.ag/8eV

@Rotelli_MD 😂😂😂 Fantastica!😂😂😂

@Ageofmyth Waiting for the Flying Purple Hippo!🦛

We've seen so many questions asking if original cheat codes will be returning in Age of Mythology: Retold—here's a screenshot of O CANADA in action. 👀 And to our friends in Canada, #HappyCanadaDay! 🍁

Discover new information about miR-218-5p mediated Parkin expression regulation in our latest paper: rdcu.be/dBYWj Thanks to @StrappazzonF and all of the authors!

Now on @BBAjournals the consequences of AurkA/TPX2 complex overexpression on chromosome segregation fidelity. Many thanks to my amazing co-first author @FedePolverino and the Guarguaglini lab for this beautiful teamwork! doi.org/10.1016/j.bbad…

Happy anniversary @CellPressNews

I wish you and your families a Merry Christmas ❤️🧬#genetics

Beautiful people, amazing science. #CFATG11