Fangyuan Cao

✨ Follow us on LinkedIn, X and our website (eventcreate.com/e/abpp2025/) to find out more! See you at the ABPP! ✨

.@guangcai_xu et al explain how nature assembles molecular weapons possessing reactive functionality (warheads) to inhibit essential biochemical machinery and outcompete other organisms in the environment: doi.org/10.1038/s41589… go.nature.com/3LrIXUx

Our latest paper just out in Nature Chem Biol describes highly unexpected cryptic enzymology, not seen before in Nature, and provides a new way to synthesise peptides (future therapeutics) using ligase enzymes. @nchembio @UoMMIB nature.com/articles/s4158…

I’m married to @Fanlin53263223. a very special day for us😁. It was great for my colleagues and friends to attend my wedding. Beautiful pictures and lifelong memories

Microglia NLRP3 inflammasome 'DUBbed' by UCH-L1 @Zhu_L_Oxford @AndreasDamiano2 @flassen_ @ProteomOX @TaoDongGroup @theRafLab @TateScience @CmdOxford @CAMS_COI_Ox @ARUK_ODDI @KirOxford @bdi_oxford @HumanGeneticsOx @Dunn_School @NDMOxford biorxiv.org/content/10.110…

Discovery of a Potent Deubiquitinase (DUB) Small-Molecule Activity-Based Probe Enables Broad Spectrum DUB Activity Profiling in Living Cells (Edward W. Tate and co-workers) @TateScience @ConoleDaniel @Fanlin53263223 @Pfizer @MajmudarJaimeen #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Now in @angew_chem a #ChemCollabs w/#PfizerChemistry and @impchemistry Discovery of a Potent Deubiquitinase (DUB) Small Molecule Activity-based Probe Enables Broad Spectrum DUB Activity Profiling in Living Cells N-cyanopyrrolidines as key electrophile doi.org/10.1002/anie.2…

Interested in pursuing an interdisciplinary PhD in Chemical Biology? Look no further! My new ChemBio lab @QM_SBBS is recruiting a student eager to study and modulate protein phosphatases by chemical biology approaches. Apply here: findaphd.com/phds/project/c… DM for a chat! Please RT

Such a great conference at #ABPP2023 in Israel! I am appreciating the poster prize for the multi-DUB probe work. A great thank to the organizers, as well as all the co-authors #Tatescience #MajmudarJaimeen #ConoleDaniel #ChrisamEnde1

@TateScience meets @mbogyo at #ABPP2023 - a fantastic gathering of probe geeks! Looking forward to both talks tomorrow too

Professor Ed Tate appointed to the GSK Chair in Chemical Biology imperial.ac.uk/news/243091/pr…

Fantastic and unique long-term position for synthetic medicinal chemists interested in research supervision, #training, #education and #innovation in #medicinalchemistry and #drugdiscovery. Based in @TateScience @imperialcollege White City Campus. imperial.ac.uk/jobs/descripti…

Three new positions available @TateScience @imperialcollege and @TheCrick, deadline 9th Nov, start early 2023 - please retweet! Postdoc positions in cell and chemical biology: jobs.ac.uk/job/CTX333/res… jobs.ac.uk/job/CTX300/res… Chemical Biology Technician: jobs.ac.uk/job/CTX316/che…

Hello All, As presented recently at the Chemical Biology meets Drug Discovery 2022 @TheCrick @RSC_CBBG and by my colleague @Fanlin53263223 at the Oxford Ubiquitomics Symposium 2022 @Ubiquitomics our preprint on the discovery of a novel class-selective pan-DUB ABP is now live!

Our second confirmed speaker at #Ubiquitomics2022 is Prof. Ed Tate @TateScience from @imperialcollege who will discuss the use of chemical probes in #drugdiscovery. Looking forward to having you back in Oxford! #ubiquitin #proteomics #omics

Unlocking New Reactivities in Enzymes by Iminium Catalysis (Poelarends) @GPoelarends @guangcai_xu #AngewandteReview #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Come learn about novel therapies in the modern world with @TateScience!!! You can find us on Imperial College Road opposite Skempton building

I hope you enjoy reading our Minireview on recent advances in iminium biocatalysis Unlocking New Reactivities in Enzymes by Iminium Catalysis pubmed.ncbi.nlm.nih.gov/35524737/

Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC) sciencedirect.com/science/articl…