RepliFate

'Just bypass it: mechanisms of DNA damage tolerance' takes a fresh look at how cells replicate damaged DNA. The review, by RepliFate-affiliated @duxin_lab (@UCPH_BRIC), revisits lesion bypass in light of recent advances 10.1016/j.tibs.2025.07.004 @MinochaSidak @molivasantiago

Thank you for highlighting this inspiring collaboration between the Artist in Residence Helen Pynor and the RepliFate-affiliated Severo Ochoa Molecular Biology Centre (CBM)

My first bachelor student successfully defended her thesis on Wednesday! An impressive piece of lab work paired with a clear, engaging defence and discussion. Congrats, and welcome to the academic club, Amélie! 🎓👏👩‍🔬

This Tuesday, RepliFate Fellows traded pipettes for pitch decks in a full-day #entrepreneurship workshop hosted by @LDC_GmbH 💡A great opportunity for our fellows to think differently about impact, #innovation, and #business development

Sometimes DNA replication hits a 🛑 roadblock. Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact. That’s the focus of our new review in @TrendsBiochem : “Just bypass it: mechanisms of DNA damage tolerance” 🔗doi.org/10.1016/j.tibs…

Another exciting research article from a member of the #RepliFate network! The @altmeyerlab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis. Check out their findings here: doi.org/10.1016/j.celr…

Sharing our latest work @UZH_en tracking DNA damage inheritance by Live+QIBC nature.com/articles/s4158…. Huge congrats to @APanagopoulos_, M. Stout and all co-authors for this tour de force! Beautifully summarized by @S_J_Aitken and E. Reilly @NatureNV nature.com/articles/d4158….

Just published! Lecona & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication VCP/p97 = checkpoint gatekeeper! Read the full article: doi.org/10.1038/s41467…

This unique collaboration aims to spark new dialogues between scientific research 🧬and contemporary art 🎭, culminating in experimental works and public engagement activities that translate complex biology into compelling artistic experiences

We’re excited to welcome artist Helen Pynor to @CBM_CSIC_UAM as part of the #RepliFate artist-in-residence program! From June 24–July 5, she’ll explore how #DNAreplication shapes cell fate & cancer, bridging science & art with our researchers. #SciArt #ArtInScience

Frogs in the lab? Yep! 🐸 Last week, RepliFate PhD students are diving into the Xenopus egg extract system at the @DuxinLab (BRIC, @koebenhavns_uni) -where test tubes meet frog magic to unravel the mysteries of DNA replication and genome integrity.

It’s time for new duo: Julius & his PI Lorenza @PenengoLab from the @UZH_en. They study the ISG15 system in DNA rep—but there’s more! One could be found scaling alpine peaks, while the other might just trade the lab for the thrill of mushroom hunting. Curious to know more? 🍄

We’re kicking off our RepliFate introductions with Phuc and her PI, @SylvieNoorderm1 from the @LUMC_Leiden! As part of the RepliFate network, they're contributing to exciting research in DSB repair. Wanna know more about their work, hobbies, and fun facts? Check out the profiles!

@pei @biotech Her goal? To observe, learn, and draw inspiration from the molecular world we study, translating the complexities of DNA replication into artistic expression. #SciArt

🎨 🔬 Science Meets Art This week, we are excited to welcome @Pei-Ying Lin to the Duxin lab at the @Biotech Research & Innovation Centre (BRIC), University of Copenhagen as part of the RepliFate Artists in Residence program. Pei will spend two days immersed in our lab routine.

Over the coming weeks, we’ll spotlight both PhD students and PIs, sharing not only their research interests but also a glimpse into their personalities.

Ever wondered where a scientist spends most of their time in the lab? Or what they would be doing if they weren’t researchers? We are excited to launch a series introducing the RepliFate researchers driving innovation in DNA Replication and Cell Fate. #PhDlife #AcademicTwitter

Maria-Elena Torres-Padilla Awarded the Leibniz-Preis 2025 🎉 👏 The German Research Foundation (#DFG) recognizes the outstanding research of Prof. Maria-Elena Torres-Padilla with Germany’s most prestigious scientific award: the Gottfried Wilhelm #LeibnizPreis. 👉t1p.de/s6uma 💡 The international top scientist from #HelmholtzMunich fundamentally changed our understanding of stem cell biology an early development. With her groundbreaking "cells à la carte" approach, the Mexico-born scientist is pioneering innovative #therapies for diseases like neurodegeneration, brain injuries, and cancer. 👉Discover more in her #interview "Empowering Cells’ and Scientists’ Potential for Cell Therapies": 🔗t1p.de/tex9p Prof. Matthias Tschöp, CEO of Helmholtz Munich, states: 💬 "Maria-Elena Torres-Padilla has fundamentally changed our understanding of early development and epigenetic regulation with her groundbreaking contributions to stem cell biology. Her scientific excellence and innovative thinking have had a profound impact on the field and inspires researchers worldwide. The Leibniz Prize is a well-deserved recognition of her exceptional achievements and lasting influence on biomedicine." 🌟 Why it matters: Her work is not just science - it’s the foundation for future #PersonalizedMedicine and #RegenerativeTherapies. About Maria-Elena Torres-Padilla: ✨Head of the Stem Cell Center (rotating), Helmholtz Munich ✨Director of the Institute of Epigenetics and Stem Cells, Helmholtz Munich ✨Director of Biomedicine at @PioneerCampus ✨Professor at @LMU_Muenchen @METorresPadilla @dfg_public @epigeneticsHMGU @MatthiasTschop #Epigenetics #StemCells #Award #Research #ResearchPioneers

Congratulations to Dr. @SylvieNoorderm1, Associate Professor at @LUMC_Leiden, and part of the ITN RepliFate, for being awarded the prestigious @EMBO_YIP position!

After an exciting internal meeting of our network, hearing about all the cool science of our trainees, we are now enjoying the open meeting with presentations of our own PIs and local replication experts in The Netherlands.