Aleksandra Filipovska

Congratulations to SWAN Genomics, Number 8 bio, @HydgeneR and All G on securing funding from a $4.75 million BioSciences Fund, designed to help companies bring their technologies to market. 🎉 ➡️ Read our story: coesb.com.au/synbio-win-for… @arc_gov_au

Great to see this work led by @LDorstyn @CCB_Research funded by @nhmrc and many years in the making now out: Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances science.org/doi/10.1126/sc…

Sun, surf and scientific talks 😎 Centre Director Ian Paulsen and COO J-L Heylen joined CoESB researchers from our @uwanews and @CurtinUni nodes for their annual Theme 2 (Synthetic Organelles) Retreat on Rottnest Island in sunny WA 🌊☀️ @TheRackhamLab @FilipovskaLab @arc_gov_au

Our story about FASTKD5 is now published at @NAR_Open. It was an amazing collaboration with @hauke_hillen and @Antonio41949078 labs. doi.org/10.1093/nar/gk… FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites

This poster is a must have for labs working on #MCS! A guide through the work of so many outstanding labs (apologies if we did not cite your work). Hang it in your office or lab, it will please your eyes and inspire your mind! Kudos to the driving force Antigoni Diokmetzidou! -LS

Dysfunctional mitochondria trap proteins in the intermembrane space | The EMBO Journal embopress.org/doi/full/10.10…

@HAntonicka @TheRackhamLab @NatureComms @laetitia_hughes @DanielleRudler @TheKids_AU @ARC_CoESB @CurtinUni @CurtinMRI Thanks Hana, loved your FASTKD5 paper!

@TheRackhamLab @NatureComms @laetitia_hughes @DanielleRudler @FilipovskaLab @TheKids_AU @ARC_CoESB @CurtinUni @CurtinMRI Congratulations! Nice work!

The discovery of CRYAB as the binding partner of TANGO2 highlights the importance of intermediate filaments in metabolism and mitochondrial function and reveals the molecular basis of TANGO2 deficiency disorder (TDD) nature.com/articles/s4146… #metabolism #mitochondria @NatureComms

It takes two to TANGO2! TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder Many thanks to our team, collaborators and reviewers. rdcu.be/epI3p #metabolism

Silencing mitochondrial gene expression in living cells | Science science.org/doi/10.1126/sc…. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, @warscheidlab & @JakobsLab .

📢 Hunter Meeting abstract submissions close 5pm AEST today! @ANZSCDB is proud to have joined forces with the Hunter Meeting 2025. Please encourage your colleagues, postdocs and students to submit their abstracts today! Link: huntermeeting.org.au/abstract-submi…

Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia? Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable staff.curtin.edu.au/explore-career…

The peer-reviewed version of our paper on human tRNA 3' processing is now published in @NatureSMB. Many thanks to the reviewers for their constructive comments! nature.com/articles/s4159… See also the very nice related work by @BMartinHallberg @no1gv: embopress.org/doi/full/10.10…

New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice! academic.oup.com/nar/article/do… #RNA #mitochondria #mtDNA

Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact. biorxiv.org/content/10.110… Muscle mito nanotunnels 1/3🧵

Mini reunion of team 'Mito Dysfunction' at @CellSymposia #CSMito2024! Wonderful to catch up with Aleks @FilipovskaLab from my PhD days in the Murphy Lab @Mito_Redox @MRC_MBU

📢Registrations are now open for the ANZSCDB NSW Meeting! Scan the QR code to secure your ticket 🎟️👇

Better CRISPR base editors! More efficient nicking of the unedited DNA strand improves the ability to edit hard to reach bases. @ACSSynBio pubs.acs.org/doi/10.1021/ac…

Our latest preprint! Some beautiful cell biology in this one. "Presynapses are mitophagy pit stops that prevent axon degeneration" biorxiv.org/cgi/content/sh… Discoveries into the cell biology of of mitophagy in axons, a disease mechanism, and a potential therapeutic avenue. 1/2

Out today! We find that an epigenetic modification (6mA) to the mitochondrial genome (mtDNA) influences lifespan and the heritability of mtDNA mutations to the next generation. It implies that epigenetics determines genetic composition in future offspring. cell.com/cell-metabolis…

We are excited to announce the 12th ANZSCDB South Australia meeting taking place on October 16, 2024! Join us for insightful talks from @McGlinnLab, @CedricBardyLab, and @Lisa_M_Nic at @unisa. Don't miss this packed event! #devbio #science #cellbiology