Henry A. Dunn

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Henry A. Dunn

Henry A. Dunn

@GPCRHenry

GPCR lover. Pharmacology / Biochemistry / Neuroscience. PI @SBRC. Assistant Professor @UManitoba. Alumnus of @WesternU @uOttawa @ScrippsResearch @UF. 🇨🇦

Winnipeg, Manitoba Katılım Mayıs 2019
633 Takip Edilen802 Takipçiler
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Henry A. Dunn
Henry A. Dunn@GPCRHenry·
Very excited to share our most recent work describing ELFN2’s function in the brain as a novel transsynaptic modulator of group III mGluRs essential for tempering excitatory neurotransmission and neuropsychiatric behaviors in mice! nature.com/articles/s4138…
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Kirill Martemyanov Lab
Kirill Martemyanov Lab@KLabGPCR·
We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! nature.com/articles/s4146…
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Henry A. Dunn
Henry A. Dunn@GPCRHenry·
@Limbictweets What a genuine and kind man he was. Condolences to all his loved ones.
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Kirill Martemyanov Lab
Kirill Martemyanov Lab@KLabGPCR·
We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao. nature.com/articles/s4146…
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Kirill Martemyanov Lab
Kirill Martemyanov Lab@KLabGPCR·
Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward. pnas.org/doi/epub/10.10…
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Henry A. Dunn
Henry A. Dunn@GPCRHenry·
Quite the surprise from my lab!
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Manitoba Neuroscience Network
Manitoba Neuroscience Network@manitobaneuro·
The 2024 MNN Research Symposium was a resounding success with ~180 Manitoban neuroscientists gathered for the latest in cutting-edge 🧠 research. Special thanks to our amazing sponsors, and @BrainCanada @VivianePoupon for joining us to discuss the future of Canadian neuroscience.
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Lorena B. Areal
Lorena B. Areal@LorenaBAreal·
First day back to work from maternity leave and starting a new job as a Research Associate @um_pharmacology. Lots of feelings but mostly excited to do science again! 🧠🥼🧬🔬#WomenInScience
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Pharmacology & Therapeutics University of Manitoba
Pharmacology & Therapeutics University of Manitoba@um_pharmacology·
Congratulations to everyone who participated in the @umanitoba Undergraduate Research Showcase, especially the winners from our department: ✅ 1st Place Poster: Kaden Baskerville (@GPCRHenry Lab) ✅ 3rd Place Poster: Louis Dela Pena (@JoelDPearson Group) news.umanitoba.ca/2023-undergrad…
uManitoba Research@um_research

🎉 Congratulations to all the winners and participants of the Undergraduate Research Showcase! 🎉 @umanitoba

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Henry A. Dunn
Henry A. Dunn@GPCRHenry·
Very disappointed to be cancelling my trip to the #2023GPCRRetreat tomorrow due to COVID. Was very much looking forward seeing everyone and returning to Montebello - a venue the retreat hadn’t been to in over 10 years and was one of my all time favourites. Enjoy, everyone!
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Henry A. Dunn
Henry A. Dunn@GPCRHenry·
@GpcReid My interpretation was that it does couple to Gs reliably (though below their set threshold) but the G15-coupling was evident. In using this DREADD, it may be important to consider that it’s effects may also/instead be coming from the G15 activation. Perhaps cell dependent also.
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Henry A. Dunn
Henry A. Dunn@GPCRHenry·
An incredible study and resource with many important findings: including reclassification of group I mGluRs and some DREADDs, to name a few! Many congratulations to Kirill, Ikuo, and team.
Kirill Martemyanov Lab@KLabGPCR

Our systematic investigation of G protein coupling profiles of 100+ #GPCRs driven by the one and only Ikuo Masuho is out after ~10 years of work. We see many interesting patterns with the help of AI. Check it out- there is a useful reference table. doi.org/10.1016/j.celr…

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BryanRoth
BryanRoth@zenbrainest·
The recent thread about diplomas in offices got me to thinking about two different offices I’ve visited. One was filled with diplomas and awards—no free space was devoid of an award or diploma. The other was filled with rock music memorabilia…I enjoyed that one immensely.
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Keşfet

@Limbictweets @BrainCanada @VivianePoupon @BeierLab @um_pharmacology @umanitoba @JoelDPearson @westernuPandP