Gregory Pacyk

The story of amylin: from physiology to therapy @NatMetabolism nature.com/articles/s4225…

You never feel blue in February in #Lisbon #Portugal

#Pharmacy Martin Moniz or cave of wonders? #Lisbon #Portugal #1Jour1Pharmacie

Many shades of yellow in #Lisbon #Portugal

New—Tubeless #automated #insulin #delivery versus multiple daily injections in children and adults with type 1 #diabetes with elevated HbA1c (RADIANT): a multicentre, international, parallel-group, open-label, randomised, controlled trial thelancet.com/journals/landi… #T1D #AID

Luís de Camões & his #pharmacy. The rest is poetry #Lisbon #Portugal #1Jour1Pharmacie

New—Diabetes and mental health thelancet.com/journals/landi… #T1D #T2D #GDM #MentalHealth fear of #hypoglycaemia #diabetes #distress #depression #disordered #eating #sleep disorders

#Literature only. But of course: #poetry or #prose? #CopenhagenAirport #Denmark

Beautiful old #pharmacy but not a real one. It is a part of exhibition at Medical Museion in #Copenhagen #Denmark #1Jour1Pharmacie

New—Clinical features, investigation, and management of Addison's disease thelancet.com/journals/landi… #adrenal insufficiency

The concert of Edvard #Grieg with Alexandra #Dariescu by #Steinway & Jean #Sibelius’ 2nd symphony conducted by Izabele #Janskaukaite @aalborgsymf

⚖️💊 What happens when weight-loss drugs stop? The uncomfortable truth This 2026 BMJ systematic review and meta-analysis delivers one of the clearest reality checks yet on weight regain after stopping weight-management medications (WMMs), including GLP-1 and dual incretin therapies . 🔍 What was studied Across 37 studies (63 treatment arms, 9,341 adults) with overweight or obesity, the authors quantified how fast weight returns after discontinuing medication, and compared this with regain after behavioural weight-management programmes (BWMPs). Follow-up extended up to two years after treatment cessation. 📉 The headline finding On average, people regain 0.4 kg per month after stopping WMMs. At this pace, baseline weight is reached again within ~1.7 years. For newer, highly effective incretin drugs (e.g. semaglutide, tirzepatide), regain is even faster—up to 0.8 kg/month, with return to baseline in ~1.5 years. 🫀 Metabolic benefits fade too Improvements in HbA1c, fasting glucose, lipids, and blood pressure closely track weight. Once medication stops, cardiometabolic markers steadily worsen, returning to baseline within ~1.4 years. Weight loss without maintenance = temporary risk reduction. ⚠️ Worse than lifestyle alone When directly compared, weight regain after stopping drugs was significantly faster than after stopping behavioural programmes, independent of how much weight was initially lost. Bigger losses tended to rebound faster—biology pushes back hard. 🧠 Why this matters Obesity behaves like a chronic, relapsing disease. Short-term pharmacotherapy without a long-term plan risks disappointment, lost benefit, and misaligned expectations—for patients and health systems alike. 🔮 Bottom line Weight-loss drugs are powerful—but they don’t “cure” obesity. Their benefits persist only while treatment continues, or if embedded in a sustained, comprehensive strategy. Stopping therapy doesn’t just pause progress—it reverses it 🚨

Natural daylight and improved glucose control in Type 2 diabetes cell.com/cell-metabolis… @Cell_Metabolism

#Pharmacy #Apteka in the centre of #Krynica-Zdroj #Malopolska #Poland

Precision Obesity Medicine: A Phenotype Guided Framework For Pharmacologic Therapy Across The Lifespan Review link.springer.com/article/10.100… @DrNadolsky @DrKarlNadolsky @drmatthewnagra @NutritionMadeS3 @BevTchangMD @MichaelAlbertMD

The evolution of C-peptide's role in diabetes care. #currentopinioninendocrinology journals.lww.com/co-endocrinolo…

Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/landi… #incretins

Male #hypogonadism caused by an intrinsic & often irreversible HPT pathology is called organic (also termed classical) hypogonadism. Organic hypogonadism has a straightforward, established diagnostic & treatment pathway thelancet.com/journals/landi… #testosterone #MensHealth

@DrDavidVernon Thank you for sharing that. She’s not very appreciated outside Denmark.

One of my favourite literary discoveries this year: Tove Ditlevsen. It was an instant attraction. She is awkward, audacious, authentic, a fine poet and a brilliant storyteller, whether of her own life or in fiction.

@DrDavidVernon I can’t agree more. Polish original is even better.

Olga Tokarczuk’s masterpiece, packed with arcane minutiae and the furious bustle of time and history. A Bruegel canvas in prose — it’s glorious.