Gabriella Estevam

@karsonchrispens correct handle - sorry for the typo!

We support active peer review and are excited to hear thoughts/feedback! (6/6)

Mutations in the kinase domain of RTKs like MET can drive disease. Small molecule inhibitors target these mutations, but acquired resistance poses a challenge. In our latest preprint, we've extended our previous 🧬DMS of MET to study this exact problem. doi.org/10.1101/2024.0…

@fraser_lab @JuraLab_UCSF @hjpimentel @willowcoyote @capra_lab @Ed_Linossi @JingyouR @protostasis @ashrayaravi @karsonchrispens

Huge thank you and shoutout to the @fraser_lab, our amazing collaborators @JuraLab_UCSF, Dr. Eric Collisson, @hjpimentel @willowcoyote @capra_lab, and the brilliant minds (@Ed_Linossi @JingyouR @protostasis @ashrayaravi @karsonchrispensshow) that contributed to this work! (5/6)

Meet Rosace, a robust deep mutational scanning analysis tool that incorporates positional information and mean-variance shrinkage. Check it out if you are running DMS experiments or handling DMS data! (1/n) biorxiv.org/content/10.110…

(6/6) Huge thanks to @fraser_lab @JuraLab_UCSF @willowcoyote @Ed_Linossi @protostasis @carla_alumine @jmmichaud and Eric Collisson!

(5/6) We support active peer review! Your feedback and thoughts are valued and welcomed.

Preprint Announcement! We’re excited to share our research on the mutational landscape of the MET kinase domain! 👉biorxiv.org/content/10.110…

@fraser_lab @hjpimentel Glad this blog post is useful!!

does anyone have some lab docs to help students prepare for effective 1-on-1s? I vaguely remember someone putting together some notes on a blog or github. TIA

@fraser_lab @Ed_Linossi Super proud of team MET and very grateful! Many congrats, especially to @Ed_Linossi!