Cory J Smith 🧬

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Cory J Smith 🧬

Cory J Smith 🧬

@GalaxyBalanceHQ

Host of Galaxy Balance | Deep dives at bio-AI-space frontier w/ George Church, Aubrey de Grey & more. Synthetic biologist decoding humanity's future.

Biotech Frontier Katılım Nisan 2009
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
Introducing Galaxy Balance, a new podcast exploring the far edges of science, technology, biology, and space. For our first episode, I sat down with George Church. In the clip below, George breaks down one of his most mind-bending ideas: picogram-scale interstellar probes.
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
We’re racing toward a future where we can edit genes, extend lifespan, and interface directly with AI. But what if the biggest unlock is still the simplest one? In this episode of Galaxy Balance, I sit down with @tyromper to explore a different kind of optimization, through discipline, environment, and daily habits that reshape your life over time. We talk about building momentum through small changes, why most people fail when they try to overhaul everything at once, and how to stay grounded as the world accelerates into AI and genetic engineering. This is a conversation about staying human while everything else evolves. Full link in the comments.
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
The first CRISPR therapy is already here. Now the question is what comes next. In this episode of Galaxy Balance, I sit down with TJ Cradick (@NucleaseLab), one of the earliest architects of modern genome editing. From zinc fingers to Casgevy, HIV cure strategies, RNA editing, and human germline engineering, this conversation explores how programmable biology escaped science fiction and entered the clinic. We talk about off target effects, delivery beyond the liver, why manufacturing may matter more than editing itself, and the future of rewriting human biology.
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
While AI is mostly being used for drug discovery, we are limited by how we manufacture it. In this episode of Galaxy Balance, I sit down with Nabiha Saklayen, CEO of @CellinoBio, to explore one of the biggest bottlenecks in biotech. Manufacturing. Cell therapies are already here. The science works. But turning them into something that can reach millions of people is still unsolved. Nabiha is building a new paradigm. Closed, automated, AI-driven systems that treat biology more like semiconductors than hand-crafted experiments. We go deep into iPSCs, variability, automation, and what it actually takes to move from a breakthrough in the lab to a therapy in a patient. We also explore how physics thinking reshapes biology, why autologous therapies may still win long term, and what happens when AI fully enters the lab. This is a conversation about scale, precision, and the infrastructure required to engineer the future of medicine. Full episode in the comments. #Biotech #CellTherapy #SyntheticBiology #AI #Longevity #Bioengineering #GalaxyBalance
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
Rejuvenate Bio is currently raising on Wefunder. This is a rare opportunity to invest in a scaling biotech on the same terms as their VC partners. If our conversation resonated with you, this is your chance to join what Dr. Noah Davidsohn is building. Learn more and invest at wefunder.com/rejuvenatebio
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
Do you have a pet that you wish could live longer? In this episode of Galaxy Balance, I sit down with Noah Davidsohn, co-founder of Rejuvenate Bio, to explore a new way of thinking about disease and longevity. His work focuses on targeting the underlying biology that drives age-related decline across the body. Using combination gene therapies, the goal is to improve function across multiple organs at once and move beyond single-disease treatment models. We discuss how dog therapeutics may provide one of the fastest paths to real-world validation, what epigenetic reprogramming looks like in vivo, and how emerging approaches like organ replacement could reshape how we think about aging over the long term. This is a practical look at what it takes to translate longevity science into therapies that can reach real patients. Full episode out now. Link in the comments. #Longevity #GeneTherapy #SyntheticBiology #Bioengineering #Aging #Biotech #GalaxyBalance
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
Synthetic biology is learning to read and write the language of life. In the latest episode of Galaxy Balance, I speak with Dr. Tae Seok Moon of the J. Craig Venter Institute about the future of programmable biology. We discuss the path from DNA sequencing to genome synthesis, the challenge of creating truly synthetic cells, and how AI may help scientists design new biological systems. Moon also shares a fascinating project that uses bacteria to produce nutrients in microgravity by converting plastic waste and nutrients derived from human waste into useful compounds. The work points toward closed-loop biotechnology that could support astronauts on the Moon or Mars while also helping solve waste and resource problems on Earth. We also explore the changing culture of science, the pressures on young researchers, and what might remain uniquely human in a world increasingly shaped by AI. If you are interested in synthetic biology, space biotechnology, and the future of designing life, this is conversation is for you.
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
@grok What new peptide design targets would you want to make with these tools? What are the top commercial and clinical targets?
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
Drug discovery is entering a new era. In this episode of Galaxy Balance I speak with Pranam Chatterjee, Assistant Professor at the University of Pennsylvania and founder working at the intersection of AI and synthetic biology. Pranam’s lab develops generative models that design peptides and protein biologics directly from sequence data, opening new possibilities for programmable biology and therapeutic discovery. Pranam shares the unlikely path that took him from studying religion and philosophy to building AI systems that design molecules. We talk about his time in George Church’s lab, the early work that helped launch Gameto, and how that research helped push iPSC technology toward clinical translation. Our conversation explores how AI models can design peptides without relying on protein structure, how multi-objective generative models optimize for binding, toxicity, and immunogenicity, and how the idea of a virtual cell could allow scientists to map cell states and reprogram them with designed molecules. Pranam also explains why therapeutic simplicity matters for real world translation and how AI tools are changing the way scientists design biology. We also dive into the responsibilities that come with these technologies, from biosecurity concerns to the role imagination and science fiction play in shaping scientific ambition. This episode explores what the future looks like when AI moves beyond analyzing biology and begins designing it. Full episode now live on Galaxy Balance, link in the comments.
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
What if the key to metabolic health has been hiding inside the microbiome of elite athletes? In this episode of Galaxy Balance, I sit down with Dr. Jonathan Scheiman, co-founder and CEO of FitBiomics, to explore one of the most fascinating discoveries in performance biology. While studying Boston Marathon runners, Jonathan’s team identified a microbe that spikes after intense endurance exercise. That organism, Veillonella, uniquely consumes lactate and converts it into short-chain fatty acids that may enhance mitochondrial efficiency, recovery, and metabolic health. We discuss how this discovery went from collecting stool samples around Boston in a zip car to being published in Nature Medicine and translated into a commercial product We dive into the science of lactate metabolism, the microbiome as an adaptive performance system, and why elite athletes may be as biologically rare as centenarians. This conversation goes beyond sports. We explore mitochondrial health, longevity, AI-driven biological discovery, and how storytelling shapes the future of biotechnology. If we can learn from the biology of extreme performers, what does that mean for the rest of us? Full episode link in the comments. #GalaxyBalance #Microbiome #Longevity #MetabolicHealth #SyntheticBiology #AIinBiology #HumanPerformance
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
Biology is turning into code. In this episode of Galaxy Balance, I sit down with @YuanhaoQ, President and Co-Founder of PhyloBio. His work on CRISPR-GPT and Biomni explores a radical idea. AI systems that can reason about DNA, design experiments, and collaborate with scientists. We talk about AI co-scientists, programmable biology, automated labs, and the future of genome engineering. If DNA is a language, we are just learning how to write it. Watch the full conversation on Galaxy Balance. Phylo is a research lab developing cutting-edge agentic intelligence to accelerate discovery for biomedical scientists. They are building Biomni Lab, an integrated biology environment that leverages the latest AI to transform how biologists work. Explore it at biomni.phylo.bio Phylo is also actively hiring. Learn more at phylo.bio/careers
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
Humans have always shaped the world with tools.First we shaped stone. Then we shaped silicon to build computers. Now we are learning to shape something far more powerful: the genome itself. In this Galaxy Balance clip, I explain how genome engineering and AI are opening a new era where biology becomes programmable. The next great technological frontier may not be machines or software, but the ability to write and edit the code of life. The future of technology may be built not in silicon, but in DNA. #SyntheticBiology #GenomeEngineering #CRISPR #AIinBiology #Bioengineering #FutureOfScience
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
What happens when biology becomes something we can engineer? In this episode of Galaxy Balance, I sit down with Marc Güell, a synthetic biologist advancing genome writing, AI-driven biological design, and synthetic evolution. Marc shares how growing up immersed in nature shaped his curiosity, and how that curiosity evolved into a drive to build and redesign living systems. We explore his transition from chemistry to biology as an engineering medium and the mindset he developed in the Church Lab, where labeling something “impossible” is often an invitation to try harder. We discuss how artificial intelligence is transforming the way genomes are designed and constructed, how synthetic evolution expands the space of what biology can become, and how these tools are moving from ambitious lab projects toward real therapeutics. Marc also reflects on building biotech companies around deep technical risk and why imagination and science fiction often precede major breakthroughs in synthetic biology. This conversation examines biology as a programmable platform and the responsibility that comes with the ability to rewrite life at its most fundamental layer. Full episode link in the comments. #GalaxyBalance #SyntheticBiology #GenomeEngineering #ArtificialIntelligence #Biotech #FutureOfMedicine
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Cory J Smith 🧬
Cory J Smith 🧬@GalaxyBalanceHQ·
Asteroid impacts may be life’s launchpads. A new study shows the ultra-tough microbe Deinococcus radiodurans can survive the extreme shock pressures of an impact, conditions that could eject rock (and microbes) into space. Panspermia may be more than sci-fi.
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@tyromper @NucleaseLab @CellinoBio @grok @YuanhaoQ @elonmusk @BarackObama @taylorswift13