Gareth Moore retweetledi
We are excited to share the latest contribution from the lab! We found that cells in gastruloids communicate to each other in order to control the timing of gastruloid symmetry breaking.
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Gareth Moore
89 posts
Gareth Moore
@Gareth_R_Moore
Postdoc @LabTrivedi🫘 PhD @TheAsheLab and @BaldockLab at the University of Manchester🪰
Barcelona Katılım Mart 2020
305 Takip Edilen146 Takipçiler
Glad to share the second half of my work on Tsg focusing on the second half of the protein! Read below for modelling, mutations, embryos and even a bit of evo-devo! 🪰
The Ashe lab@TheAsheLab
Excited to share our latest findings on the extracellular regulation of BMP signalling by Twisted gastrulation! We identify how Tsg binds the Chordin family of BMP antagonists, leading us to propose an avidity-driven mechanism of BMP signalling control. shorturl.at/VhndP
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Gareth Moore retweetledi
Congratulations to Kerim Anlaş, @nicola_gritti & @LabTrivedi @embl @the_prbb for the work on early autonomous patterning of the anteroposterior axis in gastruloids @Dev_journal.
doi.org/10.1242/dev.20…
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Fabulous Divali celebrations again this year in the lab. Thank you @Nabarundevbio for spoiling us 🪔
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Gareth Moore retweetledi
Authors from @TheAsheLab, @BaldockLab including @t_malinauskas and @Gareth_R_Moore report structures of TWSG1 in complex with a BMP ligand and show how TWSG1 inhibits signaling.
nature.com/articles/s4146…
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Absolutely delighted to share this work on the conserved interaction between Twisted gastrulation and BMPs! Congratulations to my co-first authors Tomas @t_malinauskas and Amalie, and the entire team! Take a look here: nature.com/articles/s4146…
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Very excited to share my first author paper out now in Cell Reports!
We demonstrate how heat-triggered protein condensation helps reshape PKA signalling during stress conditions. @CM_Grant @Markashe @SimonHu02406809 @astacus @MCF_UoM
Check it out here:
Cell Reports@CellReports
Isoform-specific sequestration of protein kinase A fine-tunes intracellular signaling during heat stress dlvr.it/T89c7j
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Gareth Moore retweetledi
The evolution of multicellular organisms led to the development of body structures and functions. During embryogenesis, establishing three body axes–anterior-posterior (head-to-tail), dorsal-ventral (back-to-belly), and left-right–is essential for the organism's development. 1/n
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Gareth Moore retweetledi
It's that time of year again - we are collecting donations of festive food and gifts for @EmmelinesNew to help support local families this Christmas 🎁
The collection will run throughout November - please get in touch if you wish to get involved! 🎅
@MCF_UoM @FBMH_UoM
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Gareth Moore retweetledi
Please RT - we are looking for a postdoc to investigate how signalling filopodia collect and transduce the #BMP signal in #Drosophila ovarian germline stem cells, collaborating with @ShukryHabib_Lab in beautiful Lausanne! 🪰🏔️
Full details in the ad:
jobs.manchester.ac.uk/Job/JobDetail?…
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Gareth Moore retweetledi
Lab lunch today saying hello to our new post-doc Amanda and saying gooodbye masters student Harry- well done on your hard work! 😊🪰🔬
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Gareth Moore retweetledi
🙌Friday was the last day of the Computational Modelling of Multicellular Systems course. Below is a picture of all the participants and some of our teachers.
It was great to have you here!
#EMBOMulticellModelling
@EMBO @EMBLBarcelona @EMBLEvents
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Grateful to be doing my PhD with such a great team of scientists (and flies 🪰)!
the Node@the_Node
Next in our 'Lab meeting' series is @TheAsheLab @OfficialUoM, UK! The lab investigates how cell signalling and gene expression dynamics control developmental patterning, using #Drosophila embryo and ovarian germline stem cells as models. Meet the lab: thenode.biologists.com/lab-meeting-wi…
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Gareth Moore retweetledi
We’re really excited to share our latest paper published in NSMB on the structure of #fibrillin microfibrils by #CryoEM @wtccmr @OfficialUoM
nature.com/articles/s4159…
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Gareth Moore retweetledi
Excited to share our latest research out today in @CellReports looking at transcriptional bursting of X chromosome genes in the Drosophila embryo. 🧬🔬
shorturl.at/xDL59
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Really enjoyed hearing about all the cool science going on around me in @MCF_UoM and pleased to have won a poster prize!
The Ashe lab@TheAsheLab
Brilliant to hear about the breadth of research going on here @MCF_UoM at the MCF away day, including our new neighbour @hungrytissue as well as valuable discussions about EDI 💡 Congratulations also to @Gareth_R_Moore for winning a poster prize, a great start to the year!🪰🧬🧫
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Gareth Moore retweetledi
We are hiring! There are TWO exciting new postdoc positions in the lab building upon our previous work on #BMP signaling both in the #Drosophila embryo and germline stem cells. Please RT and share, full details in the thread 🪰🧬🔬🥼
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Gareth Moore retweetledi
Great to see this work from @laurenfb267 @jenniferc_love and @y_shapovalova as part of our collaboration with @MagnusRattray published! RNA-seq, mathematical modelling and imaging ⬇️🧬🧮🔬
PLOS Biology@PLOSBiology
Modeling of total #RNAseq time series data across early #Drosophila #embryogenesis provides estimates of mRNA half-lives; single-molecule imaging reveals that unstable mRNAs & 3' #mRNA fragments are enriched in P-bodies @TheAsheLab #PLOSBiology plos.io/3CVSEai
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