Gaurav Patel

If someone told you oil prices were up 11% and the S&P 500 was basically flat, what would you immediately think had happened?

In this 2015 interview, the host — a Tsinghua University professor — expressed genuine curiosity about how Elon Musk was able to found SpaceX without prior experience and knowledge in aerospace, especially given that rocket science is one of the most demanding hard sciences — and that Musk was serving as both CEO and CTO. Musk explained that deep expertise can be built outside formal academic programs — by reading extensively, conducting experiments, and speaking directly with experts in the field.

ok so the rosie story was even more insane than it looked > be the australian tech guy who made a cancer vaccine for his dog > first try: genetic algorithms to design a new drug from scratch > works in simulation but would take years to test > second try: screen 1 million existing compounds against the mutation > two weeks of computation. find a perfect match > it's patented > patent holder says no to compassionate use > what_did_you_expect.jpg > spend two weeks just being with the dog > 2am idea: what if i just make a vaccine > chatgpt for pipeline, gemini for construct, grok for validation > 300 gigabytes of raw sequencing data to half a page of vaccine construct > university ethics approval would take until mid-2026 > dog doesn't have that long > panik > canine cancer expert connects him to a lab in queensland with existing approval > drive 14 hours to get there > inject > three weeks later the tumors swell. immune system swarming > six weeks later shrinking > two months later legs returning to normal > one mass doesn't respond > sequence it again > different cancer. the vaccine worked. the body grew a new tumor he's now building a company so every dog owner can do this he had the technology the whole time. he spent 18 months fighting for permission to use it

This is INSANE. Since Jane Street was sued two days ago, the 10 AM manipulation has stopped. Bitcoin is up 10%, adding $120 billion to its market cap, and the BTC weekly candle has turned green after 5 consecutive red candles. The total crypto market has added nearly $200 billion over the same period.

Today is my last day at Rheo. It’s been a wonderful journey, which began as a solo review and evolved into building a one of the highest quality protocols in DeFi. This shows that even small teams can do great things. I wanted to leave a record of what we built over the years, and thank our teammates and partners who contributed along the way. - invariant-driven development with global properties and accounting system laid out before a single line of Solidity was written - continuous testing with a robust 12-step CI process that includes all imaginable types of automated testing - 3x test-to-code ratio and 95–100% coverage (before AI was a thing!) - static analysis, unit tests, integration tests, fork tests, stateless fuzzing, invariant tests, formal verification - smoke tests for upgrades & governance proposals, with post-execution checks against on-chain state - auditable governance proposals through foundry scripts powered by safe-utils and tenderly-utils - accompanied more than 10 audits with multiple partners, ranging from solo reviewers and small teams to top-tier companies - aligned with external auditors on scope and focus areas, independently confirming and deep-diving into bugs throughout the reviews - hosted one of the audit contests with the highest participation rate ever (no conditional pot!) - triaging, review, and response for the (fortunately minor!) submissions received through the bug bounty program - monitoring, alerts, and automated incident response - implemented opsec and security frameworks - admin dashboards with several ops, business, and security metrics - standardized changelog and versioning for new releases - thorough documentation and protocol specs I’m proud of the systems we built and the standards we established. All our work is open source so you can check it out. Grateful for the team and excited to see the protocol continue to evolve! Looking forward to sharing my next steps in a future update.

Retail users on Coinbase have been very resilient during these market conditions, according to our data: - They’ve been buying the dip - we’ve seen a native unit increase for retail users across BTC and ETH - They have diamond hands - vast majority of customers had native unit balances in Feb equal to or greater than their balances in December

We’ve raised $30B in funding at a $380B post-money valuation. This investment will help us deepen our research, continue to innovate in products, and ensure we have the resources to power our infrastructure expansion as we make Claude available everywhere our customers are.

The state of the Internet in a nutshell: For 2.5 years, whenever I published a video on YouTube, I'd come up with a bespoke title / thumbnail that accurately described what the conversation was about. Then, during the summer, my view count fell. Nothing worked until I found a formula: "How to Write ________ Well." Always the same text. Throw an adverb in the middle, then share a quote from the interview in the thumbnail. People are 0.5% - 1% more likely to click on that title format, so the channel has exploded in growth. This title format is worse for my viewers and soul-deadening for me, but it's leading to so many more views that I'd be crazy not to follow it — and people are significantly more likely to click on videos with the formulaic title. This isn't just a story about YouTube. So much of the Internet works like this now.

NEW Crypto Yield Curve episode! 🎙️ The Business of Curation Curators are a white-hot topic this cycle - but are they a viable business? The Size team unpacks razor-thin margins, shifting incentives, and how the model could evolve to win TVL. Watch now (~19 mins)