Gbadegesin Lab

Final version of our paper SSNS candidate gene CLVS1 regulates podocyte oxidative stress— is out insight.jci.org/articles/view/…, @JCI_insight. Findings ID potential alt/steroid sparing therapy for NS

Impt piece of work on precise diagnosis of APOL1 AMKD. Pts with N264K (M1) co-inherited with G2 may have other kid dxs & not AMKD. Huge implications for use of emerging AMKD therapy and interpretation of CT. Congratulations #Simone Sanna-Cherchi and team🎉 jamanetwork.com/journals/jaman…

Enjoy this review focusing on the applicability of KDIGO 2025 guidelines on mx of Peds NS in the US. Highlight, levamisole not approved for use in Humans in the US!! Thanks @goKDIGO for a nice piece. My pleasure working with ChiaShi Wang on this🙏🏽

We welcomed 25 new members of the Robert J. #LefkowitzSociety at the #Duke #OPSD Physician- Scientist Fall Symposium. The event featured a keynote from Nobel Laurate Dr. Robert Lefkowitz & presentations from Drs. Jenny O’Brien and Michael Forrester. Thanks to everyone who joined!

🎉 Celebrate Duke’s physician-scientist community at OPSD Fall Mini-Symposium on Nov 11, 4–6 PM (MSRBIII Rm 1125)! Featuring Nobel Laureate Dr. Lefkowitz @robertjlefkowi1, research talks & awardee recognition.🥙All Duke trainees/faculty welcome! Read more: mailchi.mp/duke/opsd-sept…

Huge congratulations to Duke Pump Class of 2025👍

RAISE IT

A few more days to register to the first ever, recurrent FSGS conference !! If you are not blown away by the program, come for the food :) #rFSGS #FSGS #raredisease @ASNKidney @ASPNeph @ISGDtweets @nephcure

Our group is migrating to Bluesky platform. We have already posted a number of cool and new discoveries @gbadegesinlab.bsky.social Please follow our latest updates🙏🏽

Looking forward to having major stakeholders in the room to discuss clinical and research areas of need in rFSGS. Hopefully we can move the needle closer to effective and durable treatments @ASPNeph @ISGDtweets @nephcure 🙏🏽

@SonaliJBracken @ACRheum Congratulations!! Well deserved 🎊🎉

It was a wonderful #ACR24 and I am truly honored to have received the Distinguished Fellow Award from @ACRheum this year

Renal Cast parade 😊

Family of Kidney stones 😊

We are proud of all our Trainees and Early Career Physician Scientists at Duke. We appreciate the great mentor pool that we are blessed with at Duke and the outstanding OPSD staff, present and past. Solid leadership @MaryEKlotman @DukeMedSchool x.com/dukeopsd/statu…

🚨 Diuretics in one page

is-gd.org/en/news-from-i… Excellent easy to digest summary of our paper @NEJM nejm.org/doi/10.1056/NE… by Ms Alissa Kocer our outstanding Science Communication expert @DukeMedSchool @Duke_CTSI @DukeGenomics Thanks @ISGDtweets More work to be done ✅

@IhabFathiSulima Mongolia spots

What is the diagnosis?

@IhabFathiSulima Finger clubbing

A Patient with chronic cough. What has happened?

A great resource for genetic evaluation pre kidney transplantation. Great team work, thanks for putting the team together Dr Christie Thomas @uiowa Nephrology🙏🏽

New from @GbadegesinLab and colleagues presented at @ASNKidney #KidneyWeek and simultaneously published in @NEJM APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans nejm.org/doi/full/10.10…

15 years ago #APOL1 risk variants were implicated in kidney disease and #FSGS. Directed therapies are at the doorstep, yet, little we knew about these variants in the African continent, where this evolutionary biology tale started... UNTIL NOW nejm.org/doi/full/10.10… Read this NEJM paper from the @H3Africa Kidney Disease Research Network! The story unveils and, as usual, more questions arise: wide difference in G1 G2 allelic frequency across West Africa and even between geographically near ethnolinguistic groups; lower than expected effect size for recessive genotypes; quantifiable effect for heterozygous genotypes; and more