Richard Kuo

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Richard Kuo

Richard Kuo

@GenomeRIK

CEO and Co-founder of Wobble Genomics Tweets are my own and do not reflect Wobble Genomics. TAMA creator/developer https://t.co/eNhbhPbF2x

Edinburgh, Scotland Katılım Temmuz 2017
496 Takip Edilen827 Takipçiler
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Paolo Tarantino
Paolo Tarantino@PTarantinoMD·
ESMO25 & SABCS25 will dramatically reshape breast cancer treatment. We’re preparing an outstanding program for Miami Breast 2026 (March 5-8) to unpack the impact of these upcoming paradigm shifts. Don’t miss it: free registration using the code TARANTINO! registration.gotoper.com/mbcc-2026?_gl=…
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Paolo Tarantino
Paolo Tarantino@PTarantinoMD·
SG is a highly effective ADCs, and when used adequately, it saves lives. This includes careful management of toxicities, with prophylaxis when indicated. In this article we review the data & provide RW perspectives on the management of toxicities with SG. academic.oup.com/oncolo/advance…
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Andrew Carroll
Andrew Carroll@acarroll_ATG·
Release of DeepVariant 1.8. Large speed improvement (~67% faster) via small model for easy sites. New Pangenome-aware option. Reduces error by ~30% for vg-mapped WGS ~10% for BWA WGS ~5% BWA exome. New config for custom model users, see release notes 1/3 github.com/google/deepvar…
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Richard Kuo
Richard Kuo@GenomeRIK·
@Magdoll @PacBio This is big news! So that's including the SMRT cell and kits? Sequencing centre cost or actual customer cost?
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Liz Tseng
Liz Tseng@Magdoll·
@PacBio 4/ What does this mean for cost per sample? It means: At 10M read depth (6-plex), it is now $325 USD per sample (at list price) from cDNA generation to sequencing. At 5M read depth (12-plex), it is now $243 USD per sample.
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Liz Tseng
Liz Tseng@Magdoll·
The new @PacBio Revio SPRQ chemistry increases yield by 33% - what does this mean for Kinnex RNA sequencing? And what data is there to show it? A thread! /1 🧵
Liz Tseng@Magdoll

What’s new from @PacBio ? The new SPRQ chemistry reduces sequencing cost - now you get a $500 human genome! I’ll talk about how this affects Kinnex in a separate thread but here’s what you need to know: /1 🧵

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BioIndustry Association (BIA)
BioIndustry Association (BIA)@BIA_UK·
#Genomics is revolutionising how we understand #GeneticMaterial, offering incredible insights into how genes 🧬 function and interact. This session will explore how combining data from multiple #Biological layers—genomics, proteomics, #Metabolomics, and more—is unlocking new breakthroughs💫 ✨ Davide Gianni, Senior Director Functional Genomics in Discovery Sciences, #BioPharmaceuticals R&D, @AstraZeneca ✨ Debora Lucarelli, Chief Technology Officer, @tagomics ✨ @perman_jorayev, Ph.D., Investor, @AmadeusCapital ✨ Frances Stocks Allen, Partner, @CooleyLLP ✨@GenomeRIK, CEO, @WobbleGenomics #TechBio #TechBioUK #biotech
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Richard Kuo
Richard Kuo@GenomeRIK·
I'll be taking part in a panel discussion at the BIA Techbio event on October 16. Excited for the discussion!
BioIndustry Association (BIA)@BIA_UK

At TechBio UK 2024, we're diving deeper into the future of healthcare with our #Genomics Track: 'Beyond genomics – delivering on applications of #Multiomics.' 🚀 ➡ ow.ly/Iqh450TnRGs This session will explore how combining data from multiple #Biological layers—genomics, proteomics, #Metabolomics, and more—is unlocking new breakthroughs. 💫 📌 Davide Gianni, Senior Director Functional Genomics in Discovery Sciences, #BioPharmaceuticals R&D, @AstraZeneca 📌 Debora Lucarelli, Chief Technology Officer, @tagomics 📌 @perman_jorayev, Ph.D., Investor, @AmadeusCapital 📌 Frances Stocks Allen, Partner, @CooleyLLP 📌 @GenomeRIK, CEO, @WobbleGenomics Special thanks to our headline supporter @EliLillyandCo and event supporters @ASTRAZENECAUK, @awscloud, @Citeline, @CooleyLLP, @HSBCInnovation, @JNJNews and @lifearc1 👏 #TechBio #TechBioUK #Biotech

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The Nobel Prize
The Nobel Prize@NobelPrize·
This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms. Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: bit.ly/4dlPE6f #NobelPrize
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The Nobel Prize
The Nobel Prize@NobelPrize·
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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Richard Kuo
Richard Kuo@GenomeRIK·
@coregenomics @ambulanzen I'm also struggling with this. Feels like the scientific community just scattered and now there isn't a unified place to communicate. I'm not sure boycotting the platform has done anything other than make it harder for the community to share ideas.
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James Hadfield
James Hadfield@coregenomics·
@ambulanzen I disagree with the “drop Twitter because Elon is [insert adjective]” which is partly why I’ve stayed. But maybe I’m not motivated enough to try out other playgrounds and I’m missing out?
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Erik Garrison
Erik Garrison@erikgarrison·
making a lot of pairwise alignments (PAF) and needed a way to confirm validity of both coordinates and alignment github.com/ekg/pafcheck
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Liz Tseng
Liz Tseng@Magdoll·
Sebra: @PacBio Iso-Seq in pre-implantation embryo find novel isoforms rich in antisense and intergenic. Conserved in primates, suggesting driving recent evolution. pubmed.ncbi.nlm.nih.gov/37903791/
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Liz Tseng
Liz Tseng@Magdoll·
Use of 26 @PacBio Iso-Seq cell line data to build a RNA foundation model LoRNA to predict transcriptome architecture, including isoform abundance, exonic structures, and variant pathogenicity. #bioinformatics biorxiv.org/content/10.110…
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Liz Tseng
Liz Tseng@Magdoll·
We've updated the @PacBio Kinnex single-cell RNA SMRT Link v13.1 troubleshooting guide to cover what are the metrics you should expect and how to analyze not officially tested kits such as GEM-X. #bioinformatics pacb.com/wp-content/upl…
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Keşfet

@PLOSCompBiol @Magdoll @PacBio @AstraZeneca @tagomics @perman_jorayev @AmadeusCapital @CooleyLLP