ANRF-National cryo-EM Facility @IITK

Moreover, EP67 is also being pursued as an antimicrobial candidate showing promising indications against antibiotic resistant strains of Staphylococcus aureus including biofilm formation. #AMR @ANRFIndia @ICMRDELHI @DBTIndia @IndiaDST @IITKanpur

Interestingly, EP67 has shown promise as a powerful adjuvant in preclinical testing of next-generation vaccines against SARS-CoV-2 and other respiratory viruses. #Vaccines #DrugDiscovery

We are happy to share that cryo-EM structures of the human and mouse complement anaphylatoxin receptor C5aR1, in complex with a peptide agonist EP67, determined at our facility, have now been published in PNAS! Link: pnas.org/doi/10.1073/pn…

We are delighted that a paper including cryo-EM structures of an anaphylatoxin receptor C5aR2 determined at our facility @IITKanpur has been featured on the cover of @MolecularCell. We congratulate all the authors and wish them more success! @ANRFIndia @DBTIndia @ICMRDELHI

Link: Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors: Molecular Cell cell.com/molecular-cell…

Structure of an atypical GPCR, the complement anaphylatoxin receptor, C5aR2, involved in various inflammatory disorders, determined at our facility, is now published in @MolecularCell. It represents one of the smallest membrane protein structures determined till date by cryo-EM!

De novo design of miniproteins targeting GPCRs | Nature nature.com/articles/s4158…

A structure of CXCR4 in complex with a de-novo designed miniprotein blocker determined at our @ANRFIndia facility @IITKanpur is published in @Nature! Spearheaded by the lab of Prof. David Baker (Nobel Prize, 2024) @UWproteindesign, it also involves @arshukla and team @IITKanpur.

The cryo-EM structure of the Duffy blood group antigen, also known as Duffy antigen receptor for chemokines, determined at our facility reveals the molecular basis of chemokine promiscuity at this receptor! Preprint link: biorxiv.org/content/10.648…

Nearly a dozen different samples from various laboratories & institutions including one from @CR_UK have been analyzed at our @ANRFIndia @IITKanpur facility this month! We also had several visitors including those from @SLU_Official & @KyotoU_News for interaction & collaboration!

Two is better than one 😎. Double blockade of a therapeutic GPCR target😎. A high-resolution structure determined at our facility. Thanks to @ANRFIndia and @IITKanpur 🙏.

So nice to hear this from our users!!! Thank you!!! @ANRFIndia @IndiaDST @IITKanpur

When cryo-EM elucidates a molecular glue-like mechanism of dimerization in a non-canonical GPCR! Structure determined at the @ANRFIndia-sponsored National cryo-EM Facility @IITKanpur!

When cryo-EM helps discover a completely unexpected target for an FDA approved drug 😎. @ANRFIndia @IITKanpur

Structure of a nanobody-GPCR complex recently determined at the @ANRFIndia sponsored facility @IITKanpur! One of the smallest membrane protein cryo-EM structures (<60kDa) determined till date😎.

Another beautiful membrane protein structure determined at our facility @IITKanpur !!!

Another high-resolution structure of a GPCR regulatory protein in complex with a receptor domain determined at the cryo-EM facility @IITKanpur!

The facility @IITKanpur houses state-of-the-art 300KV microscope and associated top-of-the-line infrastructure for sample analysis.

The very first membrane protein structure (sub-3A resolution) determined at the facility @IITKanpur! A GPCR target, implicated in inflammatory disorders, in complex with a synthetic lead molecule and G-proteins!

ANRF-Sponsored National cryo-EM Facility at IIT Kanpur is now open for the users! All the necessary information is available on the website! cryoem.iitk.ac.in