Gribnau lab

📢 WE ARE HIRING! We offer a position as Research Technician in Stem Cell Biology to work in sex differences in neurodevelopmental disorders and human X chromosome inactivation. More info: werkenbijerasmusmc.nl/en/vacancy/100…

Happy to share the latest publication from the lab: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development pubmed.ncbi.nlm.nih.gov/38834912/ Congrats to @CharbelFeghaly @JeffOui94 @manucazottes @GribnauLab, David lab @ParisEpigenetix

Interested in understanding the variances in embryonic development and stem cells between mice and humans, and how these differences impact the formation of integrated stem cell-based embryo models? Delve into our lab's Catherine Dupont latest review! frontiersin.org/articles/10.33…

Cristina Gontan Pardo is gefascineerd door het X-chromosoom amazingerasmusmc.nl/genetica/crist…

An amazing Troppo Breve meeting just finished with all NOCI members in Lochem. 4 amazing days full of discussions for directions and collaborations. Special thanks to the organizers @F_deVrij, @GribnauLab and Ellen Thomassen. #NOCI #OoC #organonachip #research #troppobreve

📢 Register for the 5th 🧬 X-inactivation meeting before April 1! 📔 25 talks selected from abstracts! 📅 19.-22.6.2023 in #Berlin ℹ️ x-inactivation-meeting.org 🧑‍💻👩‍💻co-organizers: @rafaelgalupa @lab_turner @GribnauLab @CRougeulle #EMBOxChromosome23 @EMBOevents @dfg_public

Retrospective analysis of enhancer activity and transcriptome history go.nature.com/3lZYa66

We believe DCM-TM is a powerful technology for tracing genome-wide gene transcription and enhancer activity back in time without relying on predictions or the requirement to isolate stem cells. Read our paper to learn more on our findings! 🤩

DCM-Polr2b also labels active enhancers, which show a coordinated timing with nearby gene activity. We used the gene and enhancer maps to predict transcription factor activity and study the changes in chromatin landscape and lineage decision-making during intestinal homeostasis.

After many years of hard work, our DCM time machine paper is finally published in @NatureBiotech! Ruben Boers, Joachim Boers, @Beatrice__Tan, @Mariekevleeuw, @gribnau_joost and others developed a novel technology for whole-genome cell state tracing rdcu.be/c6fsf

❔ Interested in #embryoids? This @ScienceAdvances article details an optimized method for generation of ETX embryoids that developed into late #gastrulation in static culture conditions. @GribnauLab @Beatrice__Tan Check it out: bit.ly/3HjqYxk 🔬 #MicroscopyMonday

We believe this research can greatly contribute to the research into developmental events! Thank you everybody that contributed to this study! @ErasmusMC @AnZwijsen Enjoy reading!

The EXT embryoids could be grown to spatially and morphologically resemble up to E7.5 embryos. Day-7 ETX embryoids can display a headfold and formation of the heartgut region, even in non organogenesis directed culture conditions.

We are extremely excited to present the amazing EXT embryoid work Catherine Dupont, @Beatrice__Tan, Olivier Schäffers and others published this week in @ScienceAdvances. We managed to optimize protocols to create the post efficient protocol yet! science.org/doi/10.1126/sc…

New dropbox has been set up at Erasmus University Medical Center @erasmusuni in Rotterdam, NL! Pickups are Mondays at 3pm, located in the coldroom in the Ee tower (Ee 964). Thanks to Esmee Brevé for hosting this new box! 👩‍🔬👨‍🔬🧑‍🔬