the Peijun Zhang Lab

Feel so proud to share our new pre-print paper. In this work, we captured intact HIV-1 cores at different depths of the nucleus and resolved the structure of native nucleosome at 5.6 Å, revealing various classes and their interplay with the core. Check it out here! @GroupZhang

Our method paper for HIV-1 nuclear import is out now in EMBO reports! Check it out here: doi.org/10.1038/s44319… @GroupZhang @shen_yao10 @OxfordStrubi @NDMOxford @eBIC_Diamond @DiamondLightSou @emboreports

So excited to share our new work of in-cell Rubisco, now published in Nature Communications, check it out! doi.org/10.1038/s41467… @GroupZhang @Nadav_Elad @eBIC_Diamond @OxfordStrubi @NDMOxford @WeizmannScience @NatureComms

Our HIV-1 nuclear import study is now online in Nature Microbiology 📄 Read the paper: nature.com/articles/s4156… 🎥 Watch the stunning movie of the virus in action: shorturl.at/lwGo2 Huge congratulations! @OxfordStrubi @eBIC_Diamond

🔥 We caught SARS-CoV-2 in the act of membrane fusion—frame by frame! Using cryoET, we reveal the entire fusion sequence in near-native conditions—and how S2-targeting antibodies slam the brakes on it. Don’t miss it 👉 nature.com/articles/s4146… @OxfordStrubi @eBIC_Diamond

Excellent review charting the evolution of chromatin research—from foundational techniques to state-of-the-art in-cell structural biology via cryo-FIB milling and cryo-ET. A key resource for the chromatin and structural biology fields. doi.org/10.1016/j.sbi.…

I feel very excited to share our latest work (now in preprint) on the nuclear import of HIV-1. Employing correlative cryo-ET, we captured nearly 2000 HIV-1 cores associated with the nucleus. Find more in the paper 😆

Excited to share our study capturing complete fusion event snapshots of SARS-CoV-2 and its inhibition by the S2 antibody WS6 via in situ cryo-ET under near-native conditions🦠. Big thanks to Jialu Xu, Juan Shen, and Peijun Zhang. #CryoET #SARSCoV2 #CryoEM biorxiv.org/content/10.110…

🎉 Exciting news! We're hiring PDRAs starting May 2025, funded by a Wellcome Discovery Award! Join our team to unravel how HIV-1 capsids exploit host cofactors during early infection & uncover what makes the pandemic HIV-1 lineage unique. Apply now: bit.ly/4hyTBae

Congratulations to @miles_a_graham on winning the prestigious NDM Graduate Prize 2024 for his exceptional performance! 🎉Wishing him continued success for the rest of his PhD journey! Keep up the amazing work, Miles! 👏@eBIC_Diamond @OxfordStrubi

A novel cryo-EM affinity-grid approach utilizing monodispersed single-particle streptavidin on a lipid monolayer is introduced to improve particle absorption, thereby addressing challenges like preferential angular distribution rdcu.be/d1MNM @eBIC_Diamond @OxfordStrubi

Our SARS antibody platform story on NDM news page: ndm.ox.ac.uk/news/novel-ant…

Get online on Cell🎉: Our data have uncovered a plethora of antiviral mechanisms by AMETA, underscoring their unique properties and potential synergy in the development of ultrapotent, broad-spectrum, and durable antiviral therapeutics. @OxfordStrubi sciencedirect.com/science/articl…

Congrats Prof Peijun Zhang won the annual The Center for Retrovirus Research Distinguished Research Career Award vet.osu.edu/research/cente…

The University of Minnesota is hiring a Research Assistant Professor for cryoEM in the Department of Biochemistry, Molecular Biology and Biophysics. The link to the post is hr.umn.edu/Jobs/Find-Job (job ID 363926). Welcome to reach out to Luiza @luizammend with any questions

Very excited to share our first work after establishing my lab in Hong Kong University @HKUniversity Tremendously grateful to the development of PACEtomo to make the data collection possible within a reasonable period of time. @RadoDanev . nature.com/articles/s4158…

And a lovely photo on the NDM news page: Peijun Zhang elected to European Molecular Biology Organization membership ndm.ox.ac.uk/news/peijun-zh… Congrats again!

Many congrats👏 Prof. Peijun Zhang elected to EMBO Membership!🎉🎉@eBIC_Diamond @OxfordStrubi

This is the first in situ chromatin structure!

Exciting work! @eBIC_Diamond @OxfordStrubi Congratulations!