Harvard Chan Microbiome in Public Health Center

I'm excited to announce two upcoming HCMPH events. Our annual symposium (May 19th) has a fantastic line of talks lined up around the theme "the #microbiome in food systems." We're also hosting a microbiome course June 2-6. (huttenhower.sph.harvard.edu/biobakery2025/)

The largest and most diverse study yet of the gut microbiome and type 2 diabetes, led by the @chuttenh and @danielwang621 labs, reveals that the presence of specific viruses and bacterial variants in the microbiome corresponds with #T2D risk. broad.io/T2D-gut

NEXT Monday (May 13) join us at #HCMPH2024* @fasnicar will give a talk: Human gut microbiome as a tool in oncology *virtual registration is FREE hcmph.sph.harvard.edu/hcmph-symposiu… @HCMPHmicrobiome @hutlab

Wouldn't it be fabulous if you could perform a microbiome research study without worrying about sample collection, aliquoting, and storage? The Harvard Chan Microbiome Collection Core can help! hcmph.sph.harvard.edu/hcmcc/services/.

Need help planning your microbiome study, or processing, analyzing, or visualizing your data? The Harvard Chan Microbiome Analysis Core can help with all stages of a project! hcmph.sph.harvard.edu/hcmac/services/.

We are still accepting abstracts for our upcoming Symposium on May 13th. TWO posters will be selected to give short talks!

Less than one week left to sign up for our class on microbial multi-omics! Check it out below: evomics.org/2024-microbial…

We are extremely pleased to announce that Macarron has officially been published. Please check out the paper here: embopress.org/doi/full/10.10… and the software here: huttenhower.sph.harvard.edu/macarron/

Come join us at the HCMPH symposium on May 13th! The deadline for poster abstracts has been extended to April 22nd!

In a new @NatureRevCancer article, team OPTIMISTICC’s Geniver el Tekle & Wendy Garrett of @theGarrettLab @HarvardChanSPH explore the roles of bacteria in gastrointestinal tract malignancies and cancers of the lung, breast and prostate 🔽 nature.com/articles/s4156…

IID’s Wendy Garrett presented the welcoming remarks at the Harvard Chan Microbiome in Public Health Center (@HCMPHmicrobiome) fifth annual symposium.

Last at #HCMPH, @JosephPetrosino on child gut fungal profiles in TEDDY (early T1D) cohort. Child fungal profiles are quite different from adults, sometimes have unique country-specific features, & a few species were linked to future asthma/celiac.

Next at #hcmph, @racheljdutton sequences camembert cheese to model cross-feeding in microbial communities and shows that bacteria and fungi work together to digest the amino acids in casein. Fungi also help to alleviate bacterial iron uptake defects.

Next at #hcmph, @schirmer_lab shows how oral bacteria became enriched in the gut microbiomes of children with severe UC in the PROTECT study pubmed.ncbi.nlm.nih.gov/30308161/. In Veilonella, this relates to nitrate respiration.

Next at #HCMPH: @kyrpides on how 3 teams' (with @robdfinn @cibiocm ) efforts catalogued over 200,000 human gut reference genomes, and how checkV (pubmed.ncbi.nlm.nih.gov/33349699/) was developed to QC the 3.5 million viral contigs assembled from this dataset.

Next at #HCMPH, @dmap02 from #NIH uses genomics to study Candida auris transmission. She shows it is often transmitted asymptomatically on the skin, along with multiple other ESKAPE pathogens.

Next, PhD student Hayley Gause from #UCSF discusses using RNA-seq to compare E. faecalis and C. albicans co-culture in vitro and in vivo. Co-culture influenced candida's iron metabolism, transcription factors, and parasexual cycle. #HCMPH.

Next, @corinnefmaurice talks about how spontaneous prophage induction in the healthy human gut is extremely common pubmed.ncbi.nlm.nih.gov/36798434/. A cool example of how applying new software tools to an old metagenomic dataset can tell us new things!

Delphine Tripp from @conTaminatedsci lab discusses prophage dynamics in C. acnes genomes at #HCMPH. Prophage carriage is relatively rare, and the signal is phylogenetically inconsistent.

Next at #HCMPH symposium, in a meta-analysis, Emily VanSync from @ganda_lab shows that both metformin and type 2 diabetes affect the gut mycobiome, but effect sizes are smaller than previously reported (metformin R2 2%, T2D 1.2%).