Nature Reviews Cancer

Our March issue is live! 🌞 💐 It features articles on: - Targeting micropinocytosis - Phagocytosis checkpoints in immunotherapy - Therapeutic potential of cGAS-STING - Machine learning & genomics for precision oncology 📖 👇 dlvr.it/TRFWlf

Review 🚨 Baumert&Co summarize the deregulation of claudins (CLDNs) in cancer and discuss their role in tumour progression. They explore opportunities&challenges in targeting CLDN for cancer therapy. 📖 ⬇️ dlvr.it/TRS5SD

NEW content online! Metabolic vulnerability in fusion-driven ependymoma dlvr.it/TRS4Wr

#ResearchHighlight🚨 Re-routing IgE for cancer therapy: A recent study reveals that mast cells engineered with tumour-specific antibodies and an oncolytic virus can target and kill tumour cells while boosting local anti-tumour immunity. 📖 👇 dlvr.it/TRPrH8

NEW content online! Re-routing IgE for cancer therapy dlvr.it/TRLCd7

🚨 #REVIEW 🚨 Paredes et al. discuss preclinical & clinical evidence suggesting that the intestinal microbiome influences outcomes of allogeneic haematopoietic cell transplantation and, in particular, graft-versus-host disease. 👇 dlvr.it/TRHq6h

NEW content online! Claudin proteins as emerging therapeutic targets for solid tumours dlvr.it/TRFtSc

Review🚨 Rowles&Patti decode cancer with #metabolomics across scales. They discuss opportunities and challenges of metabolimics to explore how cancer cells' nutrient demands are met through metabolic interactions in the TME or systemic crosstalk. 📖👇 dlvr.it/TRBxPF

NEW content online! The intestinal microbiota as a key modulator of acute graft-versus-host disease dlvr.it/TRBSbD

#REVIEW🚨 Eckhardt et al. highlight the potential of #generativeAI to generate synthetic data that can replace real patient data in cancer research, provided that issues like standardization, bias, privacy, and quality are tackled. @katherlab 📖 👇 dlvr.it/TR9vSC

NEW content online! Artificial intelligence-generated synthetic data for cancer research and clinical trials dlvr.it/TR4Q6h

NEW content online! Decoding cancer across scales with metabolomics dlvr.it/TR4Pzd

#ResearchHighlight 🚨 Mutant HSCs display broad fitness variation. Agarwal et al. identify a germline noncoding variant that confers resilience to clonal hematopoiesis of indeterminate potential (#CHIP) by dampening expression ofRNA-binding protein MSI2. dlvr.it/TR12Fj

If you’re interested in the therapeutic potential of Neutrophil Extracellular Trap directed therapy in cancer, have a look at this excellent review by @MHShahzad5 @ronirayes and @JonathanCools in @NatureRevCancer. After 15 years of investigation, we are closer than ever to clinical implementation! nature.com/articles/s4156…

🥳And coming it at number 1🥁🥁🥁.... Our 1st most downloaded #REVIEW in 2025: Unveiling the molecular and immunological drivers of antibody–drug conjugates in cancer treatment #ADCs #antibodydrugconjugates @NatResCancer #NRCtop10of2025 dlvr.it/TQxXt9

🥳 Our 2nd most downloaded article in 2025: Targeted protein degradation for cancer therapy #PROTACs #Degraders @NatResCancer #NRCtop10of2025 dlvr.it/TQwQcW

🥳 Our 3rd most downloaded #REVIEW in 2025: Acquired resistance in cancer: towards targeted therapeutic strategies #therapyresistance #cancertherapy @NatResCancer #NRCtop10of2025 dlvr.it/TQvHtz

NEW content online! Inherited resilience dlvr.it/TQtcVm

🥳 Our 4th most downloaded #REVIEW in 2025: Neuro-immune cross-talk in cancer #neuroimmune #cancer @NatResCancer #NRCtop10of2025 dlvr.it/TQt9pL

🥳 Our 5th most downloaded #REVIEW in 2025: Cross-priming in cancer immunology and immunotherapy #TME #immunotherapy @NatResCancer #NRCtop10of2025 dlvr.it/TQs3dB