Hadeesha Piyadasa

Thrilled to share that our paper is out in @Cancer_Cell: We apply spatial proteomics, transcriptomics, and glycomics to define tumor antigens, TME organization, and predictors of grade and survival. cell.com/cancer-cell/ab…

For a deeper dive into how we built this and what we found, check out the preprint post below 👇 x.com/hadeeshap/stat…

Thrilled to share that our paper is out in @Cancer_Cell: We apply spatial proteomics, transcriptomics, and glycomics to define tumor antigens, TME organization, and predictors of grade and survival. cell.com/cancer-cell/ab…

Thrilled to share that Nimbus, our method to robustly identify cell positivity in multiplexed imaging data, is out @naturemethods! If you've struggled with cell clustering/phenotyping in imaging data, please give it a try. nature.com/articles/s4159…

(8/8) All this work would not have been possible without all the amazing people at @Bendall_Lab and @MikeAngeloLab and our collaborators. Mikaela Ribi, Ke Leow @JoleneRanek @Inna_Averbukh @meeladamouzgar @CandaceCLiu @NoahGreenwald Erin McCaffrey @rashmikumar559 Albert Tsai @MarcBosse5 @OkadaLabUCSF1 @OldridgeDerek

(7/8) Open source spatial multi-omics of human gliomas: We have made everything in this study freely available through the BRUCE data portal–a user-friendly web resource for quantitative analysis and visual data exploration of all extracted features and multiparameter imaging data - bruce.parkerici.org. For more details, check out the preprint - biorxiv.org/content/10.110…

🧵 (1/8) Today, @BenOberlton and I are excited to share the preprint of our work on: A comprehensive multi-omic study of human gliomas, spanning diagnosis, treatment, and recurrence. We address the longstanding challenge of developing effective therapies for gliomas, which have shown limited response to immunotherapy and targeted treatments compared to other malignancies. #GliomaResearch #NeuroOncology #CancerImmunotherapy biorxiv.org/content/10.110…

Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) biorxiv.org/content/10.110…

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) biorxiv.org/content/10.110…

I am thrilled to share my preprint with @Bendall_Lab that includes a new and comprehensive phenotypic atlas of human hematopoietic progenitor cells. Check out how we reconcile the diversity of human HSPCs in the tweetorial below. biorxiv.org/content/10.110…

Save the Date! Please join us in August for our 2nd Annual Spatial Biology Workshop! @_hubmap @ncihtan #spatialbiology @WellcomeLeap

@BryJCannon 🤣 one too many times

When you bike to lab on a Saturday and realize you forgot your keys but can see the machine through the window, taunting you.

Our new @_hubmap study examining how the maternal fetal interface is established in human pregnancy is out! Big effort led by @Inna_Averbukh, @ErinSoon_ , @ShirleyGreenba1. So proud of the beautiful study they completed! nature.com/articles/s4158…

Thrilled to share the preprint from my postdoc work in the @Bendall_Lab with @MikeAngeloLab and Thomas Montine at @StanfordMed looking at human microglia in situ in #aging and #Alzheimers disease by multiplexed proteomic imaging! shorturl.at/agCN0

Watch Starship’s first integrated flight test → spacex.com/launches twitter.com/i/broadcasts/1…

Excited to announce our first ever MIBI workshop! We'll be talking about the new tools our lab has developed for generating, processing, and analyzing MIBI data. We'll also be going over our workflow for reagent validation, panel design, and troubleshooting pesky antibodies.