Jack Hall

FDA just rewrote the CAR-T approval rulebook. Randomized trials. Superiority over SOC. No more single-arm shortcuts. Every program built on the old model is now repricing risk. Here's what changed - and what it means for sponsors and investors: jamanetwork.com/journals/jama/…

George Lucas on the state of film and TV today: "Nobody knows what to do. The stories they're telling are just old movies. Let's do a sequel. Let's do another version of this movie. And it's not just in movies, but in almost everything, there's no original thinking. It's like I saw something, let's do something like that." Is he on to something here?

Uncovered audio shows Anthony Fauci talking about having every major corporation require vaccinations and making it as hard as possible on citizens so they’re forced to be vaccinated He says if you make it hard enough on people, they’ll abandon their beliefs This is Evil “Once people feel empowered and protected legally, you are gonna have schools, universities and colleges are gonna say, you wanna come to this college buddy? You're gonna get vaccinated, lady. You're gonna get vaccinated. Big corporations like Amazon and Facebook and all of those others are gonna say, you wanna work for us to get vaccinate. And it's been proven that when you make it difficult for people in their lives, they lose their ideological bullshit. And they get vaccinated.”

@lralphey Interesting- Would $ions do this if confident in $arwr patent case?

$ARWR drug pricing finally gets a response from competitor. $ARWR has the best in class product. fiercepharma.com/pharma/ionis-s…

A lot of X hate on $arwr and their platform. Which imo is misguided because biotech needs both ASO and siRNA tech; multiple delivery mechanisms. IMO today’s muscle data proves they have v strong IP. Big fan of both Arrowhead and $ions. Both strong BO candidates?

So CDER approved $DNLI’s hunter syndrome drug using heparan sulfate, the SAME biomarker that Vinay Prasad’s CBER rejected for $RGNX’s hunter syndrome GTx?

BREAKING: For the first time in history, the US Postal Service announces an 8% surcharge on all packages to cover rising fuel costs.

Crony capitalism ≠ drain the swamp

$NGNE Neurogene announced they will present P1 Rett Syndrome results in 3Q26 for NGN-401 More Info: pryzm.ozmosi.com/product/29233

@SophiaRoe $arwr

@SophiaRoe With today’s $srpt muscle data- imo RBC’s $arwr M&A argument just became stronger:

Interesting action $ARWR. Could this be next on M&A list?

Also worth noting after P-PMOs failed in DMD- $srpt is currently trying I-PMOs for DMD. With I being Integrin - the same $arwr ligand they discussed today for DM1 and FSHD. Very good idea- should be best in class next gen PMO $dyn $wve $nvs :

$srpt subQ readout in Huntington’s Disease early next year just got a lot more interesting. $arwr (AD and PD also…..)

BREAKING: US oil prices rise back above $90/barrel after Iran rejects President Trump's "15-point peace plan."

US FDA approves Denali's genetic disorder therapy reut.rs/4s4TkAU reut.rs/4s4TkAU

Read Sarepta's letter to the DM1 community at: myotonic.org/sites/default/… Hear from Sarepta at our next Meet the DM Drug Developer on Friday, April 3rd! Regtister to attend & get early recording access: events.zoom.us/ev/AuhDDPjs6VS…

Crude +6.926MM, Exp. -1.25MM Gasoline -2.593MM Distillate +3.032MM Cushing +3.421MM, huge jump Production 13.657MMbpd, down 11kbpd

$TERN- cheap breakup fee, could see a bidding war IMO

ELON MUSK: "They passed a law making it illegal to show ID in any election in California."x.com/cb_doge/status… Joe Rogan: "[For] what logical reason?" Musk: "The reason is to cheat obviously." Rogan: "I think 84% of people polled believe that you should show ID to vote." Musk: "As soon as you ban ID for voting, it makes fraud impossible to prove."