Jing Liang 🇺🇦

@Biomaven I didn't say that. Are you replying to someone else?

@AppleHelix I don't think it's correct that the Arnold foundation is against HIV and HCV drugs - best I can tell they've pushed for wider access.

Claude was able to find Vinay Prasad's CV from 2023 (for tenure application?). onlinelibrary.wiley.com/pb-assets/CV%2… VP actually received 2 separate grants from the Arnold Foundation. One from 2017-20, the other 20-23. And probably is still supported by the foundation. Total from 2017-23 was ~$4m. Most recently, the foundation was funding VP $800K per year.

ADCs (including multiple-payload ADCs) in focus at #AACR26, via @Apexonco -> oncologypipeline.com/apexonco/node/… $STRO $ALPMF $GSK $ZYME $IPN.PA

@DrToddLee VP would say something about FCOI here :)

@AppleHelix And?

@s86CoffeeDev @JeffreyLowMD LDLmaxxing BioX 😂

@JeffreyLowMD @AppleHelix Nice ldl

Built a health dashboard at 3am during paternity leave with Claude Code. No engineering background. Pulls my labs, trends everything, generates a printout I hand my doctor. Every health app gives you 50+ metrics and no context. The value isn’t the dashboard. It’s knowing what belongs on it. What would you put on yours?

Hmm probably not a good idea to remove bone marrow fat...

This definitely looks like a cardiac safety signal at the higher doses. The GLP-1's all slightly increase pulse rate as a starting point.

There's an old joke in systems biology called "How Biologists Fix a Radio." A biologist, tasked with figuring out why a radio doesn't work, removes components one by one and catalogs the result. Remove this transistor: the radio makes a horrible screeching sound. Conclusion: this is the "horrible screeching transistor." Remove another component: the radio goes silent. Conclusion: this is the "silence transistor." This is essentially what we do with genomics. We see which genes are mutated in cancer and assume they must be "cancer genes." We see which genes are differentially expressed and assume they must be "important." But correlation is not causation, and a parts list is not a circuit diagram. You can have a complete inventory of every resistor, capacitor, and transistor in a radio and still have no idea how it plays music.

@chillipickle7 Just noting the coincidence. Seems like being affiliated with Arnold Ventures helps you get hired at the senior level

I'd like to see Makary removed (not least to lighten my $QURE bags)... but why does it matter if he and VP received grant funding from AV? I don't understand how this is controversial.

Okay, Before today, I knew Arnold Ventures funded Vinay Prasad - but I didn't know the amount. Today I learned that: - Vinay Prasad was funded by ~$4m grants from 2017-23, and continues to be funded by AV - Marty Makary was also funded by AV - $500-$1m in grants - Tracy Beth Hoeg was supported indirectly by Arnold Ventures while working in Vinay Prasad's lab So basically Arnold Ventures was able to place ideologically aligned people at the FDA. TO BE CLEAR, I think @Arnold_Ventures does great things. I agree with its goal of lowering cost of medicines. However, I disagree with its approach. I also think sometimes, they end up funding ideologues - people who wants to "prove" their biases rather than being evidence or fact-driven.

@unfixed_income @BeachedCapital The interlining materials used by CT for seams and collar is very high quality. I have never seen the fabric come unglued from it.

@AppleHelix @BeachedCapital Agree have a bunch of super slim left from 2016-2019, they seem to never wear out. My Etons as well as MtM Edit Suits shirst both give up faster in general.

Is anyone else still daily wearing Charles Tyrwhitt white buttons down shirts they bought in 2013 as a banking analyst? Or just me?

I agree with this. Ideology conflict of interest rather than financial conflict of interest.

Impressive long-term data from the large (n=396) phase 1 trial of SHR-A1811 (aka T-Rez 🦖). Similar structure to T-DXd, similar PFS in HER2+ & HER2-low MBC, but much lower rate of ILD (2.5%, 1 G5 event). Important to validate these results in western pts. nature.com/articles/s4139…

@PearlF @docrodwong but what is the source document?

@AppleHelix @docrodwong The FDA Commissioner has also received $ from them. Quick Gemini search showed Makary’s group at Hopkins received at least $1.8M from the family

@emilyakopp @daphnezohar x.com/adamfeuerstein…

@daphnezohar Could you point to an example of them being called too negative?

The trade press in biotech does an important service of reporting on industry news, which requires balancing skepticism/objectivity while also editorializing and acknowledging good/bad news when warranted. They get accused of being too negative & serving short sellers by some and then get called industry shills by others🤷🏻‍♀️

@BeachedCapital The super slim fits (they don't make them anymore) look good.

@AppleHelix They look horrible in person. For zoom calls, they’re getting the job done.

Get the PBMs out of hospitals. They are giving incentives for hospital pharmacies to gouge the public. Hospitals buy drugs for pennies on the dollar and sell at retail. The more expensive the drug the more the PBM makes, they don't care about the fraud hospitals are doing