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Seems like highlighting molecular biology artefacts is a real trend for publications in 2024. Pleased to share @RegGenomics and I's work on the role of RNA in PRC2 recruitment @CellReports.
cell.com/cell-reports/f…
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Alex Hall Hickman
19 posts
Alex Hall Hickman
@HallHickman
A post-grad researcher investigating the regulatory effects of G-quadruplex RNA on chromatin - Regulatory Genomics Group - UCL Cancer Institute
UCL Katılım Ekim 2020
120 Takip Edilen55 Takipçiler
Alex Hall Hickman retweetledi
In our new paper aided by single molecule imaging of RNA and transcription machinery we demonstrate how Polycomb Repressive Complex (PRC) represses transcription in live cells 🧵 nature.com/articles/s4155… 1/9
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Alex Hall Hickman retweetledi
Re-analysis of CLAP data affirms PRC2 as an RNA binding protein and XIST RNA as a target.
We (YongWoo Lee, Roy Blum, Michael Rosenberg) examined the datasets of Guo et al. (PMID 38387462 - which reported that PRC2 is not an RBP) ...
biorxiv.org/content/10.110…
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Alex Hall Hickman retweetledi
Apparent RNA bridging between PRC2 and chromatin is an artifact of non-specific chromatin precipitation upon RNA degradation dlvr.it/T3R1Wn
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Alex Hall Hickman retweetledi
1/ Is RNA essential for PRC2 chromatin occupancy? Here we refute evidence that was previously used to support this idea.
Work by @evan_healy4 and @QiZhang85 from the @DavidovichLab, @MonashBDI, @EMBLAustralia.
cell.com/cell-reports/f…
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Alex Hall Hickman retweetledi
Every angle, every call – how the broadcasters celebrated Shamar Joseph and the West Indies' historic Gabba win #AUSvWI
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Alex Hall Hickman retweetledi
Really looking forward to our next @irelandchrom webinar on Friday Nov 3rd at 4pm GMT / 5pm CET.
Richard Jenner @RegGenomics from @UCL will speak on ‘Understanding the effects of RNA on PRC2 and other chromatin regulators’. Please register at: lnkd.in/enJPyet6
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Without Googling, name one thing invented by the Chinese
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@stojic_lovorka @RegGenomics @QMULepigenetics @BiochemSoc Thank you Lovorka. It was a pleasure to meet you this week!
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Potten End, England 🇬🇧 English
Alex Hall Hickman retweetledi
Congratulations to @HallHickman for winning best poster @BiochemSoc Transcription and Chromatin for his work on PRC2 and RNA!
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What a wonderful couple days of science 🧬
Huge thanks to @doctorconnor, @PradeepMadapura and Sonia Rocha for organising such an enjoyable symposium!
@BiochemSoc #BiochemEvent
Pradeepa Madapura@PradeepMadapura
Congratulations to @andreannafw and @HallHickman for winning @QMULepigenetics sponsored poster prizes at @BiochemSoc #biochemEvent on chromatin & transcription
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Alex Hall Hickman retweetledi
@RegGenomics @HallHickman Congratulations Richard and team! Really important work!
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Alex Hall Hickman retweetledi
You were told that RNA is essential for PRC2 chromatin occupancy.
We examined key evidence that previously supported this idea: it's an artefact.🧵
biorxiv.org/content/10.110…
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Excellent descriptive from Richard (@RegGenomics) detailing our work highlighting the loss of PRC2 chromatin occupancy under rChIP conditions as a symptom of non-specific chromatin precipitation. Please also check out the parallel study from @DavidovichLab @evan_healy4 @QiZhang85
Richard Jenner@RegGenomics
1/8 Our new pre-print from @HallHickman is out biorxiv.org/cgi/content/sh… We report that the apparent RNA bridging between PRC2 and chromatin observed by Long et al 2020 using rChIP is an artefact of non-specific chromatin precipitation Please alert colleagues using this method!🧵
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Lab Life: When your PhD (almost) falls apart doi.org/10.7554/eLife.…
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Alex Hall Hickman retweetledi
Really great mechanistic work to understand PRC2 dysregulation by a common fusion protein in endometrial stromal #sarcoma. Congrats @Manuel_TavaresC . We need more like this!
JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell... sciencedirect.com/science/articl…
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Alex Hall Hickman retweetledi
Just a reminder there is one more week to apply to the #postdoc position available in my lab to work on the effects of nascent RNA on chromatin at @uclcancer
Please see: atsv7.wcn.co.uk/search_engine/…
Richard Jenner@RegGenomics
We have a postdoc position available! If you’re interested in #RNA or #chromatin and especially both together then please apply! Deadline Feb 16th. Link:atsv7.wcn.co.uk/search_engine/… Please retweet!
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