Hanwen Wang

A cloudy day in New Jersey

From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling @HopkinsPopelLab arxiv.org/abs/2403.03335

Winter Milky Way at the bottom of Suntop Lookover near Seattle (with rented Canon Ra and Sigma 14mm f1.8)

Last night was cloudy, but managed to capture part of the Cygnus constellation with the North America Nebula. Also my first time using a star tracker.

Antares (心宿二) and ρ Ophiuchi (心宿增四) taken with my new Canon T7 (25-min total untracked exposure) at White Lake Natural Resource Area, 140-km north from Philly. Need to find a darker location next time...

Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition @HopkinsPopelLab nature.com/articles/s4169…

Predictive models of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using nuclear morphology and tissue architecture cell.com/cell-reports-m…

Integrating single cell sequencing with a spatial quantitative systems... sciencedirect.com/science/articl…

Decrease in tumor content is associated with improved treatment outcome response to Pembro in patients with rare tumors jitc.bmj.com/content/8/1/e0… by Coya Tapia, @DrPhyuPAung2 @Sinchita_Roy et al. Collaboration with pathologists is a must. #USCAP2021 #USCAP2021VNI #molpath #cytopath

In Silico Virtual Clinical Trials of Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer- @HanwenWang95, @HopkinsPopelLab, @JHUBME, bit.ly/2MWeYcT #ASCPT2021 #ASCPTposter #ASCPTSystemsPharmacology

New #JITC article: TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism ow.ly/Cf7w50DPieG

New #JITC article: Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer @HanwenWang95 ow.ly/4K6H50DAZ3G

In this simulation, a black hole’s intense gravity warps the image of the disk of hot, glowing gas surrounding it. Now, scientists wonder whether black holes really are the strange beasts Albert Einstein’s theory predicts. fcld.ly/v6zunsh @ScienceVisuals @NewsfromScience

New #JITC article: Therapy of lymphoma by immune checkpoint inhibitors: the role of T cells, NK cells and cytokine-induced tumor senescence jitc.bmj.com/content/9/1/e0…

Modelling of Immune Checkpoint Network Explains Synergistic Effects of Combined Immune Checkpoint Inhibitor Therapy and the Impact of Cytokines in Patient Response mdpi.com/910038 via @MDPIOpenAccess

Here is the full sequence of the Pfizer vaccine, courtesy of the WHO. 4284 nucleotide, 1273 amino acids. All U are 1-methyl-3'-pseudouridine. PolyA has strange structure, is broken up with GCAUAUGACU.

Complete populations of virtual patients for in silico clinical trials academic.oup.com/bioinformatics…

Shaped by modern chemicals, antibiotic medicines, processed foods and sanitation, the microbiome of humans living in the industrialized world is unlike anything ever experienced before by human populations, argues this Science Review from last year. fcld.ly/87mkack

Welcome home, Chang’e 5! #ChangE5

Imagine a dragonfly so big its wings could block a 27-inch TV screen on.natgeo.com/2WeMkF5