Popel Systems Biology Lab

Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade | PNAS pnas.org/doi/abs/10.107…

@hopkinskimmel investigators develop computational tool to predict immunotherapy outcomes for patients with metastatic

We all enjoyed and were inspired by Shayn Peirce-Cottler’s talk! Congratulations on being the 2024 Eugene M. Landis Awardee! @PeirceLab #VascularBiology2024

Just had an amazing dinner with my PhD advisor, Dr. Sasha Popel @HopkinsPopelLab @JHUBME. His exceptional mentoring has been instrumental in shaping the person I am today. Forever grateful for his guidance and wisdom!

Many congrats to @JGreenGroup on your installation as the Herschel L. Seder endowed Professor of @JHUBME!

Really thankful to my mentors. Wouldn’t be possible without my awesome advisors @FertigLab @ltkagohara @HopkinsPopelLab

From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling @HopkinsPopelLab arxiv.org/abs/2403.03335

Our latest modeling work integrates signaling and biophysical modeling to investigate how red blood cells are recognized and recycled in sickle cell disease, now in @PNASNexus. Thank you to our colleagues and collaborators at @jhubme @BrownUniversity @MIT doi.org/10.1093/pnasne…

Watch a simulation of a macrophage engulfing an old, rigid red blood cell that needs to be recycled. The simulation was produced as part of a modeling study on macrophage dynamics that could help develop therapies for sickle cell disease. In PNAS Nexus: ow.ly/Om8r50QuQOu

Congratulations!!!

A few months ago, I posted about the @biorxivpreprint for spatial transcriptomics analysis of HCC. The paper is now published at @GenomeMedicine! 🎉🎉🎉 Many thanks to my collaborators for their amazing team work!!! Open access through the link: genomemedicine.biomedcentral.com/articles/10.11…

Huge thanks to team members in @HopkinsPopelLab and @FertigLab. Shout out to @ltkagohara and @atulpdeshpande for great mentorship! We are thrilled to see mathematical modeling spatial data from clinical trials coming together.

Macrophage–endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa: buff.ly/3YmW7YN @SumaginLab @NUFeinbergMed #CellBiology #Inflammation

This month, COWIMS highlights Dr. Shayn Peirce-Cottler for her brilliant work as Professor and Chair of Biomedical Engineering! Dr. Pierce-Cottler is also the PI of UVA’s Microvascular Engineering Lab. To learn more, visit peircecottlerlab.com. @PeirceLab

A much needed call from @MathCancer to create a “Modeling Grammar.” A dictionary for hypothesis rules, modeling components, signals and processes will indeed facilitate reproducibility and communication across disciplines. Application to @PhysiCell was presented #SMB2023

Please see our latest work, just published on @ScienceAdvances: A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition science.org/doi/full/10.11…

Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition @HopkinsPopelLab nature.com/articles/s4169…

Congratulations to Theinmozhi Arulraj! Her amazing work on omics-informed #QSP model of #breastcancer metastasis has won the Oncology Session Award at the @ISOP1 QSP Student Symposium 2023!

Our review of systems biology models and omics of angiogenesis signaling published in @WIREs_Reviews is among the top downloaded papers! Read on for more: doi.org/10.1002/wsbm.1…

We are thrilled to share our latest paper "Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico …." published in @Cancers_MDPI. 📷 Read the paper: [mdpi.com/2072-6694/15/1…] 📷 Congrats to the team and @mehdinik85 📷 #QSP #ABM #ITH #CancerStudies