Hasan Mamar

@sihemzenbio @PNASNews @IGDRennes @SprteVillejean1 Congratulations Siham! 🎊 🥳

Excited to share our latest paper published in @PNASNews! @IGDRennes @SprteVillejean1 🥳🥳🤩Check out the paper here: pnas.org/doi/10.1073/pn…

@AsAshraf123321 @NAR_Open Thank you @AsAshraf123321 !

@HasanMamar @NAR_Open Congratulations 🎊

Excited to see my PhD work published @NAR_Open, describing an HR-independent #PARPi sensitivity upon loss of #polymerase epsilon accessory subunits POLE3-POLE4. POLE4 loss enhances sensitivity of #BRCA1-deficiency & bypasses resistance due to 53BP1 loss. doi.org/10.1093/nar/gk…

@Ella_Maru @NAR_Open Thank you @Ella! While we haven't tested it directly yet, we think it's due to POLE4 ensuring stable binding of polymerase complex to DNA. Upon its absence, continuous repriming leaves gaps accumulating behind the fork, exacerbating replication stress in BRCA1-deficient cells.

@HasanMamar @NAR_Open Impressive work, Hasan! How does POLE4 loss specifically alter replication fork stability and influence PARPi sensitivity in BRCA1-deficient cells?

@bexsmithnz2 @BiologicalRese1 @SprteVillejean1 @sihemzenbio @bowchro @BiochemOxford Thanks a lot @bexsmithnz2

@sihemzenbio @bexsmithnz2 @BiologicalRese1 @SprteVillejean1 @bowchro @BiochemOxford Thank you @sihem!

@bexsmithnz2 @HasanMamar @BiologicalRese1 @SprteVillejean1 @bowchro @BiochemOxford Great work 🤩

@MichaelNADbio @NAR_Open Thank you so much @Michael!

Immensely grateful to my supervisor Gyula Timinszky & Roberta Fajka-Boja (shared 1st author) for unforgettable journey. It was a pleasure collaborating with Haracska lab (@BiologicalRese1) @SprteVillejean1, @bexsmithnz2, @sihemzenbio, @bowchro & Lakin lab (@BiochemOxford)

#PARPi leads to accumulation of ssDNA gaps in POLE4 KO, due to impaired post-replicative repair. This induces #replicationstress phenotypes mediated by ATR and DNA-PK. Consequently, POLE4 KO are hypersensitive to ATRi and its combination with PARPi.

@sihemzenbio Congrats Siham! Have fun in NY!

Excited to kick off my journey as a new post-doc researcher at Eli Rothenberg’s lab, part of NYU Grossman School of Medicine. Thrilled to delve into new scientific adventure while enjoying this inspiring view from my new workspace🌟🔬

@bowchro Tesco, et al.

The role of ADP ribosylation in replication as told by the birthday card stand.

Grateful to @ANoireterre for preparing this @preLights digest of our latest #preprint #ADPribosylation #PARP

@DangH_Nguyen Thanks a lot! I appreciate taking the time to read it.

@HasanMamar Congratulations!!! Looking forward to reading it!

Thrilled to see my first first-author PrePrint online 😃, describing an HR independent sensitivity to PARPi upon deletion of accessory subunits of DNA pol epsilon. Grateful to work with Roberta Fajka-Boja(co-first) and my supervisor Gyula Timinszky #PARP #ADPribosylation

@MichaelNADbio Thank you so much for the support Mike!

@SprteVillejean1 Thank you so much!

@bowchro Thanks a lot Andrew!

Well done Hasan!

@sihemzenbio Thank you Dr. Siham! 😉

@HasanMamar Wonderful work 😍 congrats Hasan

@_ayybengulerim Thanks a lot Fatma!

@HasanMamar Congrats Hasan 🥳

Another fun work with our friends @SprteVillejean1 @sihemzenbio & @bexsmithnz2

Big thanks to all my colleagues at Timinszky lab who aren't on X. And to the Haracska lab our collaborators at @BiologicalRese1