Peter Clarke

"Equal parts satire, odyssey, and fever dream..." My new novel it out now from @slicesofanxiety!

"We need to make more food with less land." - @MikeGrunwald

There's a $101 million competition happening right now to extend human healthspan. Not in mice. Not in worms. In people. XPRIZE Healthspan launched in 2023 and runs through 2030. The goal: develop a therapy that restores muscle, cognitive, and immune function — all three — by 10 to 20 years in people over 50. The treatment must take one year or less. robertlufkinmd.substack.com/p/744-teams-ar…

The man who talks to his dead animals has proven substantially more capable and stable than our reality show president. This is in large part because Millei actually knew things about economics and just played a madman for show. Alas we got the authentic buffoon.

My end-of-the-world bet with @ESYudkowsky is now in its NINTH year. I WILL win on January 1, 2030. Disagree? I'll bet anyone with a public reputation at 10:1. How CAN you bet on the end of the world? Simple: The optimist prepays the pessimist. betonit.ai/p/my_end-of-th…

all this should be in california. but texas has a more welcoming business env. at some point perhaps california voters will wake up and stop empowering people who see economic growth only as a source of taxation to redistribute...

Conservatives Are Degeneracy Hypocrites peterclarke.substack.com/p/conservative…

Fun fact.

something about sf makes it seem like a videogame map instead of a real place what do you mean it's rectangular and packed and on the far west there is "Ocean Beach" and "Land's End" wait is there literally a Treasure Island on the map too 💀

I just discovered my philosophical DNA. My strongest tendency: Promethean. diagnostic.millermanschool.com

milei putting up some extraordinary numbers: argentina's inflation went from nearly 300% to below 40%. gdp up 4.4%.

And yet, without photo ID, our elections have been remarkably fraud-free. This fixation on a non-problem is weird and wasteful.

@realpilleater @allgarbled I drove past that place every day and lived further up the road in one of the box houses by the coast. The house had this great view of the ocean but I rarely got to enjoy it because the landlord and roommates were always watching sports and yelling at the TV.

@HeyPeterClarke @allgarbled I lived right next to the Boulevard Café, and those apartments have cockroaches and homeless people trying to break in. You look out the window and then besides daytrading, you just write the great American novel. Then you walk down JDB towards Nation’s and Target. Repeat.

I find Daly City to be one of the most depressing places I’ve ever been to. Maybe it’s the fog, but I think it’s also more than that.

The transformation of liberals into "progressives" since 2013 has seriously been the worst thing to happen to American culture in my lifetime. Just absolutely gutted so much of what was good about this country. End of a golden age.

@realpilleater @allgarbled Had the exact same experience. Rented a room in Westlake for two years and they were the most depressing years of my life.

@allgarbled I survived here for two years and honestly I don’t know how I made it out of Westlake.

Whether the next president is a Republican or a Democrat, can we have someone with at least a little class next time? Because this is embarrassing.

My monthly column is out for The Grey Swan Investment Fraternity. I wrote on how OpenClaw could reshape Silicon Valley's power structure. Sign up for a subscription to read my full article. greyswanfraternity.com

FDA Clears First Age Reversal Trial (Nature Biotechnology / Life Biosciences) The FDA just cleared the first-ever human trial of cellular age reversal. This is not science fiction. As a medical school professor, I can tell you this moment will be in textbooks. Life Biosciences received IND clearance to test ER-100 -- a gene therapy that partially resets the age of human cells. The science: Yamanaka factors can fully reset a cell to a "blank state." But that's dangerous -- cells forget their function and can form tumors. Life Biosciences uses only 3 of 4 factors to partially de-age cells while they maintain their identity. The first trial targets optic neuropathies -- age-related vision loss. In animal models (including primates), the approach restored youthful gene expression in aging eyes. Why this matters: aging cells accumulate metabolic damage -- insulin resistance, mitochondrial failure, inflammation. Resetting cellular age could reverse the metabolic dysfunction driving every chronic disease. We've gone from treating symptoms to reversing the root cause of aging. Full breakdown coming on the Health Longevity Secrets podcast. Source: nature.com/articles/s4158… #AgingReversal #Longevity #CellularReprogramming #MetabolicHealth #Biotech

Here's my full conversation @MikeGrunwald on our food system crisis youtube.com/watch?v=8h_7pQ…

Regenerative farming sounds nice but is in fact largely a failed experiment.

it’s always like this