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Chad Hicks
217 posts

Chad Hicks
@HicksChadW
CryoEM Scientist and facility manager at the Boston University Cryogenic EM Core Facility
Katılım Ağustos 2014
214 Takip Edilen217 Takipçiler

How many civilian airlines must Russia shoot down before the world realizes that Russia will not stop until it is stopped?
euronews.com/2024/12/26/exc…
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@WordenEvan @VAInstitute Congratulations! Those look like very challenging cryoEM structures. I'm excited to read about it!
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Pleased to present our first preprint on how de novo DNA methylation occurs in di-nucleosomes. Lots of surprising findings about the linker length dependence of DNMT3 binding and activity. A great collaboration with the Peter Jones lab @VAInstitute.
tinyurl.com/47pmv7hy
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Join our Biomolecular Pharmacology Program @BUMedicine
vimeo.com/1035301649/6af…
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Seaport selfie after our #Cryo-EM mini symposium with fantastic talks by Yiorgo Skiniotis, Elizabeth Wright and Hao Wu.
#CAMed #BostonUniversity #structuralbiology #MolecularPharmacology

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@Adrian_H Loading control band "smiling" upward smearing at far left and right wells are normal. "Smiling" artifacts in the middle wells is unusual and indicates that these are two gels spliced together?
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@peiferlabunc @CWolberger You can trace the general path of the disordered H3 tail to the Haspin active site in a low-pass filtered map! The final few residues that make contact with the active site are well resolved after performing a local refinement of Haspin alone!
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Check out our new structure of a histone H3T3 kinase that binds in a DNA supergroove - where the major grooves of adjacent DNA gyres face one another. No contacts with the histone octamer core - not even the acidic patch!
Chad Hicks@HicksChadW
I am thrilled to share a preprint of my PhD project revealing the cryoEM structure of Haspin kinase bound to nucleosome at a DNA supergroove! biorxiv.org/content/10.110…
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@FilipGarbicz Thank you!! We should be able to release the three PDBs soon!
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@HicksChadW Amazing, I've been working with Haspin a little bit. Will there be a PDB attached?
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I am thrilled to share a preprint of my PhD project revealing the cryoEM structure of Haspin kinase bound to nucleosome at a DNA supergroove!
biorxiv.org/content/10.110…
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Wow we got Chromatin Haiku'd! Now I've officially made it as a scientist...
Chromatin Haiku@ChromatinHaiku
Nucleosome bound At DNA supergroove The haspin kinase #ChromatinHaiku #H3T3
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@AHollandLab @CWolberger @SanimRahman4 This project was conceptualized as a way to provide a useful and fun cryoEM experience to Hopkins Summer Academic Research Experience (SARE) scientist Stacy Vasquez during her senior year of high school last summer. We were really surprised by the results...
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I am very grateful to the amazing scientists and coauthors. You are all awesome, and I am so proud of our discovery! @AHollandLab (Colin Gliech), @CWolberger lab (Xiangbin Zhang, @SanimRahman4), Baltimore Polytechnic Institute (Stacy Vasquez).
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@dabiophysicist Thanks! Many of the nicest looking pictures of the eclipse are also composite images from many different photos. These here are single photo images, so that's probably why they look more natural!
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@HicksChadW These are great, thanks! I find most photographers focus on one aspect, instead of approximating the naked eye view (which is very difficult). Your no. 1 here is among the better ones
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Time-lapse of a Glacios 2 cryoEM delivery at @BUMedicine @BU_Tweets! Can you guess how many crates? #CAMED #EstherBullitt @vannazachariou.
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