International Transmembrane Transporter Society

📣 We are now accepting session proposals for our 10th Anniversary meeting #ITTS_2024 Oct 29 - Nov 1 in Washington DC, USA. Proposals related to any class of membrane transporters are welcome! Deadline for submission is Jan 31. Further details on website ittsociety.org

Repeat after me: LAB WEBSITES MATTER! While it may seem like a nice-to-have... in today's world, it's a need-to-have. For you, your trainees, and your prospective team members. I couldn't have written this better myself: nature.com/articles/s4225…

Honored to have our work with @AleBonifazi @anewman2014 @BarbaraSSlusher and others as #paperofthemonth and cover by @Diabetes_ADA! We created new drug tools to study how #dopamine in #brain vs #pancreas regulates blood sugar. @PittPsychiatry @NIDDKgov doi.org/10.2337/db24-0…

📣 📣 📣 We are excited to announce that registration and abstract submission are now open for the 3rd ITTS meeting to be held Oct 29 - Nov 1 at the @NIH campus in Bethesda, MD! See website 👇 for program and further info. ittssymposium.vfairs.com

Cryo-EM structure of ACE2-SIT1 in complex with Tiagabine | Journal of Biological Chemistry jbc.org/article/S0021-…

Human XPR1 structures reveal phosphate export mechanism | Nature doi.org/10.1038/s41586…

🎉 Exciting news! Our final manuscript is now published in @NatureComms! 📄 We reveal that the orphan human SLC22A10 gene is a unitary pseudogene due to a fixed missense mutation (P220), while its orthologs in great apes (L220) are capable of transporting sex steroid conjugates.

Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2 nature.com/articles/s4146…

Important findings on the LAT1/4F2hc heterodimer super complex formation from Robinson/Zhou labs. Super updates on the SLC7 family. PE binding sites verified with MS! nature.com/articles/s4146…

Excited to share our study on a high-affinity choline and ethanolamine transporter, FLVCR1, published today at Nature. I am grateful for my doctoral advisor ,@HiteLabMSKCC , my co-authors and collaborators, @TimCKenny, @ArtemAKhan, and @KivancBirsoy. doi.org/10.1038/s41586…

(1/8) Do you eat enough choline? Have you even heard of it?? Choline is super important for the brain and must come from your diet 🐟🥚🥦 Here @Nature we show that FLVCR2 transports choline into the brain and use #cryoEM to show how! 🧠🔬 @pippomancia nature.com/articles/s4158…

An exciting time in Solute Carrier research. Here are some of the areas where SLC structural biology is heading and where future opportunities for new discoveries and therapeutic interventions await. rdcu.be/dE759 nature.com/articles/s4159… @BiochemOxford @KavliOxford

Transport mechanism and pharmacology of the human GlyT1 cell.com/cell/fulltext/…

"A structural biologist's dream" is the caption of this Figure 😉 From a beautiful new review of cryo-EM for structural and cell biology @Nature nature.com/articles/s4158…

Thank you to @BiochemSoc and my nominators for this award! Science is a team pursuit and this award recognises the hard work of the talented students, early-career researchers & collaborators I am fortunate to do science with! @syd_health #TransporterBiologyGroup

Our 2025 International Award goes to Prof Renae Ryan at @Sydney_Science! @renaemryan1 is internationally recognised for her work elucidating the fundamental molecular mechanisms of transport proteins, ultimately transforming our understanding of transport across the cell membrane

Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters | Nat Plants doi.org/10.1038/s41477…

Conformational changes in the Niemann–Pick type C1 protein NCR1 drive sterol translocation | PNAS pnas.org/doi/10.1073/pn…

Mechanical activation opens a lipid-lined pore in OSCA ion channels | Nature doi.org/10.1038/s41586…

Happy to share a first peek at some of my postdoc work, which has been a really fun team effort with Aya, Johannes, and some other great collaborators! biorxiv.org/content/10.110…

Excited to share our latest collaboration with the @corrylab and Zhang Lab, this time on OSCA/TMEM63 channels out today in @Nature @VictorChangInst nature.com/articles/s4158…