Ian Yen

Excited to share our new book chapter! We summarize recent advances in the structures and mechanisms of non-fimbrial adhesins in biofilm formation, with perspectives on upcoming discoveries in this field. #BiofilmResearch #Adhesins link.springer.com/chapter/10.100…

Just in time for #WAAW, collab with the Strynadka lab ⁦⁦@UBC -⁩ Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance. ⁦@McMasterIIDR⁩ ⁦@BBS_McMasterU⁩ ⁦#AMR nature.com/articles/s4146…

Our new review on regulation of #T4P type IV pilus assembly #buildingpermits, by PhD candidate Nathan Roberge, is now available for you to enjoy with your morning coffee! 😀 @McMasterIIDR @BBS_McMasterU @MacGlobalNexus @machealthsci journals.asm.org/doi/epub/10.11…

Happy and proud to see this paper online! We resolved the in-situ architecture of the P. aeruginosa Type IV pilus machine and discovered the localisation and role of PilY1. Great collaboration with @JunLiuLab @Dr_Lori_Burrows @BrunLabCaulo @PLynneHowell . nature.com/articles/s4146…

15/ Many thanks to members of my lab for their tremendous support and to @RubinsteinJohn lab members (@think_zesty, @CourbonGautier, @hanlinw222, Hui Guo, @JustinDiTrani, @SBenlekbir, Zhijie Li) for teaching me #cryoem from scratch. Happy reading! biorxiv.org/content/10.110…

14/ I would also like to acknowledge a complementary study from Harry Low's lab, where they propose a different CpaF catalytic mechanism. nature.com/articles/s4146…

Happy to share my first PhD paper from @PLynneHowell lab with my fantastic post-doc mentor @gregbwhitfield from @BrunLabCaulo as well as @Dr_Lori_Burrows and @RubinsteinJohn with #cryoem support where we propose how the bifunctional Tad pilus motor works🧵 biorxiv.org/content/10.110…

1/ #CryoSPARC v4.6 is out! 🚀Up to 2.1x faster refinements and classification, a new job tree view that is scalable and performant on large #cryoEM projects, job groups, new cards and table view, automatic inspect picks, and more! cryosparc.com/updates