Structura Biotechnology

🚀Introducing fully automated data processing for repeat-target #cryoEM. Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention. Preprint: biorxiv.org/content/10.110…

@CSHL @NYSBC_Science @FredSigworth @DJx1001 This afternoon was a conference room day practical where our trainees processed a hemoglobin dataset using #cryoSPARC v5. The students worked in pairs & at the end of the day showed off their results, including what they learned. ebi.ac.uk/empiar/EMPIAR-…

🚀 Hiring: Cryo-EM Application Scientist, Marketing! Develop & deliver high-impact scientific marketing content, illustrate the value of new #CryoSPARC features & #cryoEM advances, & help scientists understand how our tools can help solve their problems. structura.bio/careers/applic…

Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge

On a gruelling hunt for rare associated molecules in your #cryoEM particle stack and not sure where to look? Discover practical tips and tricks in our new case study using #CryoSPARC v4.7.1 where we find and refine a low-population interaction partner! guide.cryosparc.com/processing-dat…

At cryosparc.com/automated-work… we provide instructions and CryoSPARC Workflow JSON files so that users can get started with automation easily. Reach out at discuss.cryosparc.com/c/automated-wo…. Happy processing!

Automated processing unlocks several benefits. Time-to-structure can be greatly reduced and throughput can be easily scaled for repeat-target use cases. Solving multiple structures per day can now become a reality. 🚀

🚀Introducing fully automated data processing for repeat-target #cryoEM. Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention. Preprint: biorxiv.org/content/10.110…

End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC biorxiv.org/content/10.110… #biorxiv_biophys

NCCAT is offering a 1 week #cryoEM workshop focused on the theory and practice of single-particle analysis March 16-20, 2026. More details may be found on our website: nccat.nysbc.org/activities/cou…

Using 3DVA of @cryosparc, we were able to image the full conformational landscape after ATP hydrolysis, and propose a function for the ABC signature motif. A big thanks to the authors and especially to my supervisors @Vincent_Chaptal and Pierre Falson! #CryoEm #membraneproteins

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles biorxiv.org/content/10.110… #biorxiv_biophys

Advanced #cryoEM workflows are easy in #CryoSPARC: use Low-Level Results to combine upstream extracted particles with downstream pose and CTF information, use a volume result from an intermediate iteration of a refinement to create a mask, and more! guide.cryosparc.com/application-gu…

Disulfide-based dimerization of modified nanobody scaffolds enables higher-order assembly for high-resolution cryo-EM structure determination that is widely applicable to small protein targets nature.com/articles/s4158…

We’re scaling structure as a core capability in AI-native drug design. #TeamGenerate is searching for an Executive Director of CryoEM to lead a multidisciplinary team operating within one of the most advanced high-throughput structural biology platforms in the world. Reporting to our Chief Technology Officer, you’ll set the vision and deliver on the execution—expanding what’s possible in structural throughput and data quality. You’ll partner closely with machine learning, automation, and protein science teams to embed #cryoEM into a true design–build–test–learn loop. This is an opportunity to shape a capability that will transform structural biology from a bottleneck into a high-speed engine for discovery—redefining how medicines are conceived, designed, and developed. If this sounds like your next challenge, let’s talk. generatebiomedicines.com/open-positions…

Flexibility can be frustrating when processing a #cryoEM dataset. If your target has a wobbly domain, check out our new case study on FaNaC1 for continuous heterogeneity tips in #CryoSPARC! guide.cryosparc.com/processing-dat…