William F. Wells

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William F. Wells

William F. Wells

@InmunoAnonimo

Hablo de ciencia, del SARS-COV-2 y de Long Covid. Me encantan los hilos largos, casi kilométricos. Todo lo que digo son mis opiniones. Respeto ante todo

Ciudadano del mundo Katılım Ocak 2024
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William F. Wells
William F. Wells@InmunoAnonimo·
Decía Machado que una de las dos Españas ha de helarte el corazón. A mi me lo han partido las dos. A ver si desde esta cuenta anónima puedo intentar divulgar algunas cosillas científicas en este país maniqueo de blancos y negros
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Christos Argyropoulos MD PhD 0kale/acc 🇺🇸
Some of the conversations about #longcovid (LC) are delusional, frankly wrong and will actively harm people. Learn to think through the groups of possibilities first after loosely defining #longcovid as the sequeala of the acute infection (perceived as a respiratory infection with some extra stuff by most). For example, in the absence of concrete evidence to the contrary (no such evidence exists), LC includes phenotypes of 1) irreversible damage (think myocardial infarction/stroke both in the covid and in the non covid settings), 2) potentially reversible (think autoimmunity/inflammation/vascular involvement after the virus has left the body) and 3) reversible damage (vital persistence leading to inflammation as a localized continuation of the acute infection, think of a urinary tract infection). Therapies against: 🛑irreversible damage can never exist unless longevity/regenerative medicine research delivers in some unidentified time point after 2050, 💔potentially reversible autoimmune damage may exist but will probably require lifelong therapy unless CRISPR/CAR-T/CAR-NK deliver 🥳potentially reversible may exist, but will require prolonged and complex regimens that potentially vary according to local sites affected. Since no therapies have clearly been identified for any of the three and research has not even started for the feasible (2 and 3) categories, one is left with *prevention of infection* as the only mechanism to reduce the prevalence of #LongCovid after repeated infections at the societal level and time to heal (perhaps) the 💩 sequelae at the individual, hoping that the time to recovery will not be long enough to a) lose many productive years of one's life and b) potentially reversible damage to evolve to irreversible one (think of polyarteritis nodosa in chronic hepatitis B, cryoglobulinemic vasculitis and membranoproliferative glomerulonephritis in hepatitis C and liver cancer in both hepatitis B and C). If you are fine with hoping that you don't need to practice prevention against covid because therapies against #longcovid are just around the corner (this is the DELUSION), be my guest; after all #UDoU. But please don't peddle your copium to the gullible.
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William F. Wells
William F. Wells@InmunoAnonimo·
Cosas como estas son las que deberían estar haciendo @Monica_Garcia_G y @javierpadillab: ocuparse de la salud en vez de dedicarse a la "política barriobajera" de controversias inútiles o a la "política internacional" donde tampoco tienen competencias x.com/BMG_Bund/statu…
Bundesgesundheitsministerium@BMG_Bund

.@ninawarken: „Wir möchten mit der neuen Allianz eine wichtige Botschaft an alle Betroffenen und ihre Angehörigen senden: Wir setzen die angekündigte Stärkung der Versorgung und Forschung durch eine enge Zusammenarbeit aktiv um. Wir lassen die Betroffenen nicht allein!“

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William F. Wells
William F. Wells@InmunoAnonimo·
Importante artículo sobre cómo el covid afecta a la salud metabólica (ojo, que no hablamos de personas con #LongCovid sino de todos los que lo han pasado). Debería ser lectura obligada para políticos y "expertos" y ocupar la primera plana en telediarios x.com/ZdenekVrozina/…
Zdenek Vrozina@ZdenekVrozina

A new metabolomic study does something important. It looks directly at the biochemical products circulating in plasma - a real-time readout of how cells are functioning. And the results are clear - even clinically recovered individuals show measurable metabolic and proteomic deviations from uninfected controls.🧵

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David Lingenfelter, PhD
David Lingenfelter, PhD@dlingenfelter·
The PolyBio Symposium focused on Long COVID and ME/CFS, highlighting persistent SARS-CoV-2 in tissues and complex immune dysregulation. New diagnostics (Viper) and 2026 clinical trials for antivirals and immune-boosting treatments were also discussed. youtube.com/watch?v=dGbb7U…
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David Lingenfelter, PhD tweet mediaDavid Lingenfelter, PhD tweet mediaDavid Lingenfelter, PhD tweet media
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Henry Madison
Henry Madison@RageSheen·
I wanted to re-share this, to emphasise again that our worst problems impact everybody, but solving them means targeting only TINY numbers of people and places - hubs in networks. It’s backwards to target everybody, in mass movements. The task is MUCH easier than that.
Henry Madison@RageSheen

POW camps in the Korean war explain a lot about the total capitulation to Covid today. Nearly 40% of US prisoners died, the highest death rate in US military history. But the camps were only weakly fortified, prisoners had adequate food and water and were usually not tortured. /1

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William F. Wells
William F. Wells@InmunoAnonimo·
En España el 57% de la población padece una enfermedad crónica. Las infecciones virales persistentes, como el covid o el EBV, son una de las principales causas y se pueden prevenir y tratar. Menudo caladero de votos que perdéis con la inacción @Monica_Garcia_G @javierpadillab
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William F. Wells
William F. Wells@InmunoAnonimo·
Una nueva investigación muestra que el virus de Epstein Barr causa el Lupus. Cada día está más claro que los virus son la causa de la mayoría de enfermedades "para las que no hay explicación". Todavía estamos esperando a que los "expertos" informen a la sociedad sobre el tema
Zdenek Vrozina@ZdenekVrozina

A new study may finally explain how EBV triggers and worsen lupus. A paper in Science Translational Medicine + Stanford Medicine report just clarified a question researchers have chased for decades.
How can a virus that almost everyone carries ignite lupus in some people?🧵

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Jon Douglas
Jon Douglas@atranscendedman·
Researchers studied how metformin works differently from other biguanides. Using cryo-EM, they found metformin enters complex I only when it is open and blocks CoQ10 in the closed state, revealing why it’s safer and effective. nature.com/articles/s4159…
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Zdenek Vrozina
Zdenek Vrozina@ZdenekVrozina·
A interesting paper in Nature Structural & Molecular Biology finally reveals how metformin really works inside mitochondria. It doesn’t shut down energy - it fine-tunes the flow of electrons through complex I🧵
Jon Douglas@atranscendedman

Researchers studied how metformin works differently from other biguanides. Using cryo-EM, they found metformin enters complex I only when it is open and blocks CoQ10 in the closed state, revealing why it’s safer and effective. nature.com/articles/s4159…

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Zdenek Vrozina
Zdenek Vrozina@ZdenekVrozina·
Long COVID in women and men are not the same disease. They share symptoms, but diverge in biology - immune, hormonal, and genetic. After months since the preprint - peer-reviewed study is now out in Cell Reports Medicine.🧵
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William F. Wells
William F. Wells@InmunoAnonimo·
@censorship_suks @RageSheen Ignorance can be cured reading. Make a try, the truth is just a few keystrokes away from you. Covid is still a thread, is still killing and it's still disabling. Your ignorance won't stop it.
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Censorship Sucks
Censorship Sucks@censorship_suks·
@RageSheen This mental illness is a threat to civilization. The "virus" mutated into basically nothing.
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Henry Madison
Henry Madison@RageSheen·
Infection is the greatest enemy to civilisation itself. Its greatest weapon is its capacity for ongoing undiagnosed chronic impact. It takes up residence. Acute SARS-Cov-2 infection is just the on-ramp to the main game. Fools focus on the acute phase.
Vipin M. Vashishtha@vipintukur

We’re now in the 6th year of the COVID-19 pandemic. ➡️ What began as a respiratory illness has evolved into something deeper — a prolonged impact on the immune system. This is what some call the ‘Leonardi Effect’, after immunologist @fitterhappierAJ ➡️ He warned early that SARS-CoV-2 could hyperactivate T-cells — the cells that drive our immune defense. This overdrive may: • Cause tissue damage • Exhaust T-cells • Reduce immune memory • Leave us less protected against future infections. 1/

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William F. Wells
William F. Wells@InmunoAnonimo·
Cada vez siento más respeto por los ingenieros, la verdad. El comentario de uno al que admiro: "Las infecciones son el principal enemigo de la civilización" Siempre lo han sido, solo hay que leer algo de historia. Lo increíble es que nadie del ámbito sanitario lo diga.
Henry Madison@RageSheen

Infection is the greatest enemy to civilisation itself. Its greatest weapon is its capacity for ongoing undiagnosed chronic impact. It takes up residence. Acute SARS-Cov-2 infection is just the on-ramp to the main game. Fools focus on the acute phase.

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AJ Leonardi, MBBS, MPH, PhD
AJ Leonardi, MBBS, MPH, PhD@fitterhappierAJ·
In 2020 I wrote a paper claiming the lymphopenia in Covid included Apoptosis, or T cell death I made this "extreme" claim after reading the 1st paper on Covid's clinical course Now, a paper claims ongoing T cell death is shaping population immunity 1/ link.springer.com/article/10.118…
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