Nanda Iryuza

🫀📉 Can more intensive LDL-lowering improve CT-FFR in stable chest pain? This new JACC study evaluates whether intensive lipid-lowering therapy (statin + ezetimibe) alters CT-derived fractional flow reserve (FFR-CT) — a noninvasive marker of lesion-specific ischemia — in patients with stable chest pain and coronary atherosclerosis. 🔍 Study essentials Patients with stable angina and coronary plaque on CT angiography were managed with aggressive lipid-lowering using statins plus ezetimibe, targeting substantial LDL-C reduction. FFR-CT was measured at baseline and on follow-up to assess functional changes in coronary physiology attributable to therapy. 📈 Key message The core focus — integrating structural and functional imaging — points to a key concept: lipid-lowering can potentially improve lesion physiology, not just plaque burden. By using FFR-CT (a validated surrogate for invasive FFR), the authors are examining whether aggressive LDL-reduction actually shifts physiological indices toward less ischemia. 🧠 Why this matters Lipid-lowering benefits have traditionally been shown at the event level (MI, death). Structural plaque regression with statins/ezetimibe is documented in IVUS and CT studies. But fewer data exist on functional improvement in coronary blood flow with therapy. Linking lipid therapy to improved FFR-CT suggests that LDL-lowering may not only slow plaque progression but also improve coronary physiology — a potential mechanistic bridge to clinical benefit. 📌 Bottom line: Intensive lipid-lowering might influence not only plaque morphology but lesion-specific ischemia as assessed noninvasively, expanding our understanding of how therapies translate into physiological improvement.

Wonderful to host @Iryuza our interventional fellow from Indonesia who has been with us for the past year for a PCI / TAVI fellowship . It is his last week with us and has been a joy to have him here. Looking forward to a long collaboration with many more fellows

@mmamas1973 Thank you very much Prof, for having me here. I am very grateful for the opportunity and the experience.

@wita_desandri You deserved it lass 🫡

Dimulai sekolah FK di thn 2005, boleh lah ya apresiasi degree diri sendiri stelah 20 thn bolak balik sekolah dan thn ini lulus MSc sports cardiology distinction di London dgn usia yg gak muda2 amat lg 🥲 nanges. dr. Dwita RD, Sp.JP, Subsp. PRKv(K), MSc.

@Laserrman @realarainmd @cto_chip_japan @DaitaroK @calcbreaker @UmihikoKaneko @SKuramitsu0511 @tadano98 Great case Sensei. Thank you!

LAD #CTO #HDR #APT Tip injection shows microchannel to DX→Anyreach P 3G→HDR shows Type 2B→GW crossed DX→#IVUS shows LAD stump→Anyreach 0.6G with H curve with DLC→DTL DES and DCB @realarainmd　@cto_chip_japan　@DaitaroK @calcbreaker @UmihikoKaneko @SKuramitsu0511 @tadano98 @rotamonster @OpolskiMP @jcspratt @KambisMashayek1 @LAzzaliniMD @AgostoniPF @skat_ct @mornei2011 @uziyahya46 @DrBIqbal @Bernard_TW_Wong #MedTwitter @akbarul @K_DeSilva @evandrofilhobr @MichaelMegalyMD @asaadnakhle @SCVC2023 @girishviswa1　@baijazvascular @ErwMulia @jbspadoni @GTawade84　@drAliyor @SandyCTO #cardiotwitter @PCRonline @SCAI　@ikki1127 @CtoEuro @SPyxaras　@JuradoRomanAl　@JiunnWen_Lin @MLCTOAcademy @shci_sec　@drdharmarajk @sapporohunt @ogoktekin

Great honor to have my mentor, Prof. @mmamas1973 in Jakarta for ISICAM! Proud to do a successful live case together at the National Cardiovascular Center Harapan Kita. Educational, inspiring, and memorable. Hope you enjoyed the event! @ISIC_Official @aninkasaboe

Great evening at #ISICAM gala dinner with dancing, singing 😬 and friends @aninkasaboe @Iryuza @uziyahya46 teguh santoso @Laserrman What a great meeting, the warmth friendliness and joy of the Indonesian doctors is the best

Great to do opening live case at #ISICAM with medina 1.1.1 lms disease and diffuse lad disease. Oct and physiology guided provisional hybrid approach with prox lad stent into lms, then cutting balloon guided seloution dcb in mid lad with @Iryuza @aninkasaboe @uziyahya46 @mirvatalasnag

💡 See Beyond the Vessel — Master Coronary Physiology! Join our hands-on Workshop on Physiology and learn how to guide treatment & optimize outcomes through evidence-based physiology and imaging integration. 🗓 Wed, 5 Nov 2025 | 🕐 13.00–17.00 WIB 📍 Jawa Room, Shangri-La Jakarta 🔗 Register now at isicam.id #ISICAM2025 #StayOnTrack @uziyahya46 @Iryuza

🔥 Hidden Dangers, Visible Impact! High-risk plaques may stay silent — until it’s too late. Discover how advanced imaging transforms early detection into life-saving action. 📅 Fri, 7 Nov 2025 | 🕚 11.00–12.00 WIB 📍 Ballroom A, Shangri-La Jakarta 🚀 Don’t miss your next breakthrough — register now at isicam.id #ISICAM2025 #StayOnTrack @uziyahya46 @mmamas1973 @RoccoVergallo @IndahSP_MD et al.

@ErwMulia @mmamas1973 See you there soon Bang @ErwMulia 🫡

@mmamas1973 thank you Sir…see you there @Iryuza

Excited to join this meeting in Jakarta Where i will be performing a live case The program is truly innovative

Pinned: Cardiovascular Physiology Hub Discovering physiology together: untangling the concepts most often misunderstood at the bedside. Foundations – Starling’s law as servo-control x.com/icmteaching/st… – Cardiac output & Anderson’s model x.com/icmteaching/st… – Preload x.com/icmteaching/st… – Making sense of acid–base x.com/icmteaching/st… – Afterload & systemic vascular resistance x.com/icmteaching/st… Concepts in flow & pressure – Critical closing pressure & waterfalls (series)  • Part 1 x.com/icmteaching/st…  • Part 2 x.com/icmteaching/st… – High-output heart failure x.com/icmteaching/st… – Why is CVP in the MAP equation? x.com/icmteaching/st… – Tissue perfusion x.com/icmteaching/st… Frameworks & applied physiology – Shock: pump vs pipes framework x.com/icmteaching/st… – Interface model of shock x.com/icmteaching/st… – Cardiac output monitors x.com/icmteaching/st… – Sepsis does not cause hypovolaemia x.com/icmteaching/st… Why RCTs fail (3-part series) – Part 1: Consensus, thresholds & physiology x.com/icmteaching/st… – Part 2: Heterogeneity vs colliders x.com/icmteaching/st… – Part 3: Beyond colliders x.com/icmteaching/st… I’ll keep adding here as new threads drop.

Planning a PBMV? Don’t start without this! Dr. Walsh shares a concise, practical prep guide easy to bookmark and refer back to. #CardioTwitter #CardioX #CathLab

Nonculprit Vulnerable Plaques and Prognosis in Myocardial Infarction With Versus Without ST-Segment Elevation: A PROSPECT II Substudy: @CircAHA 🥸 Rx of nonculprit lesions in STEMI or NSTEMI: @GreggWStone 😱 Summary 👇👇👇

This is the new #PPG Pullback Pressure Gradient - a new physiology-based paradigm in coronary decision-making High PPG = focal CAD / Low PPG = diffuse CAD We hope PPG helps us become better interventional cardiologists🙏 @PCRonline @AbbottCardio @coroventis @TCTMD @CoreAalst

TIMI Flow: A Key Indicator of Coronary Perfusion TIMI (Thrombolysis in Myocardial Infarction) flow grading is a crucial angiographic tool to assess blood flow in coronary arteries, particularly after an intervention like PCI. 🔹 TIMI 0 (No Flow) – Complete occlusion; no antegrade flow beyond the blockage. 🔹 TIMI 1 (Penetration without Perfusion) – Minimal flow beyond the occlusion but without adequate distal vessel opacification. 🔹 TIMI 2 (Partial Flow) – Delayed but complete filling of the distal vessel; flow is slower than normal. 🔹 TIMI 3 (Normal Flow) – Full, brisk perfusion with normal distal vessel filling, comparable to a non-diseased artery. TIMI 3 flow is the gold standard for successful reperfusion in PCI, improving outcomes in STEMI and other coronary syndromes. #Cardiology #TIMIFlow #CathLab

🔥#ACC25 Late-Breaking Trials 🔥: FLAVOUR II 🔗pcronline.com/News/Whats-new… @ANazmiCalik provides his take ✍️ on this trial of angiography-derived #FFR versus intravascular ultrasound to guide PCI in patients with coronary artery disease #interventionalcardiology #Clinicaltrial #cardiotwitter

Bifurcation Cases With OCT and Coronary CT-OCTOBER and P4 Trials x.com/i/broadcasts/1…

🚨Dr. Bernard De Bruyne’s @BernardBruyne Physiology Masterclass episode is now live! 🚨 Learn how coronary physiology is helping us understand plaque rupture. 🫀💥 What stood out to you in this episode? Let us know in the comments!👇 Want to watch the previous Physiology Masterclasses? Find them all here: coreaalstplatform.com/coreaalst/modu… @EmanueleBarba13 @ColletCarlos @SimoneBiscaglia @jeroen_sonck @CardioAalst @OLVZaalst #Cardiology #PhysiologyMasterclass #FocalDisease #DiffuseDisease