Isaac Fisher

The indiscriminate and ill-conceived slashing of indirects by the @NIH yesterday must be amended if want to restore America’s leadership role biomedical research. 15% simply isn’t enough for institutions to provide the basic infrastructure needed to run a successful lab. I say this as someone who has been and remains deeply critical of the NIH, its funding system and of the ways universities are structured and spend money. We would all benefit from a genuine reexamination of how and to what @NIH funds are allocated, and I remain optimistic that once the dust settles and new NIH leadership is in place that this is what will happen and this hack job by people who don’t understand or care about research will be forgotten. And I’m sorry but I can’t help but laugh at the people who are demanding a full-throated defense of the current indirect levels. Nearly every PI I’ve known for my entire career has complained about excessive indirect rates. This is mostly because, despite their importance, even most PIs haven’t bothered to actually understand them, and because they don’t FEEL that universities are actually spending the money to support their research. Whether they are or not nobody really knows because in the typically Byzantine maze of university budgets it’s often very hard to figure out. There are also lots of actual shenanigans that go on especially at places with the highest indirect rates to use funds to build out the institution and increase its power rather than to directly support funded research projects. And anyone who says administrative bloat at universities isn’t real and partially fueled by indirects is either blind or part of the bloat. So let’s get organized to have an actual constructive response to this firebomb. Scientists need to advocate for what is best for research - and we have to do it ourselves because the institutions that claim to represent us - universities and scientific societies in particular - have their own goals that often do not align with ours. We also have to remember that grants are not an entitlement. We are not owed anything. If we want to continue benefiting from the public support we have always enjoyed, we have to show the public and their representatives - even ones we might not always agree with - that we’re spending their money wisely.

Core facilities are truly one of the most undervalued assets in an academic institution. They are often treated as also rans, staffed by non tenured faculty with little leeway, and given an exceedingly short runway to become profitable. In an age of shrinking lab sizes and astronomical maintenance contracts, cores will increasingly become the engines that fuel research. Institutions have to invest in core facilities in order to spur innovation and efficiency, and expect some will be a “loss leader” on revenues, with intangible returns on research productivity. For those on the job market, getting to know the institutional core facilities and directors should be an indispensable part of the recruitment process. Talk one to one with some of the core directors. How institutions approach core facilities is a huge “tell” on institutional research ethos.

@dgonzales1990 When your first student graduates.

@jenkins_paul @mike_feigin

Research is 50% fuck around and find out/50% fuck up and find out

@weinberz I've seen your microscopy, Id say yes.

There is only so much serum protein right?

I’m in medicinal chemistry and this week I learned that heteroaryl [REDACTED] can inhibit [REDACTED] receptors You can learn about this in 3-5 years

Cryo-EM is addictive! Recognize the warning signs early with this #cryoEM #Memes .

I will keep maxing out these nonsense categories until grad programs phase them out.

Sci Hub is a "pirate" website with 88M research papers freely available. Using it is not advisable. We should all try to make billion-dollar acdemic publishers richer. Here's a thread on integrating Zotero with Sci Hub to get free articles. PLEASE DON'T DO THIS 😉

“Aim 4:..” Let me stop you right there

A friend sent me the updated scientific method

💀

For the structure nerds: the snapshots were ordered based on increased completeness and improved local resolution of the propeller density inside the CCT chamber. This enabled us to model how the protein transforms from a molten globule to a fully folded state.

Have you ever read a bad or wrong paper in a peer-reviewed journal?

@BiophysicalSoc @Kadidia_S @NOBCChE @PurdueChemistry Congrats Kadidia! Way to represent the Lyon lab!

Congratulations Kadidia Samassekou @Kadidia_S, for earning the Distinguished Poster Award sponsored by the Biophysical Society @NOBCChE! @PurdueChemistry#NOBCChE2023 #NOBCChE50

Shiny new project. Do you have the time? No: --> Don't do it. Yes: --> No you don't.