Isabel Mayayo-Peralta

🧬1/ How do SHRs regulate transcriptional activity, and which components of the SHR-coregulator complex are essential for transcription? Our study, published in @NAR_Open, used a FACS-based CRISPR screen to dissect the GR complex. academic.oup.com/nar/advance-ar… 🧵

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator biorxiv.org/cgi/content/sh… #bioRxiv

@ipaniaguac @NAR_Open Thank you @ipaniaguac !! ☺️☺️☺️

@IsabelMayayo @NAR_Open Congrats @IsabelMayayo!! So nice to see this story published 🥳🥳

🧬1/ How do SHRs regulate transcriptional activity, and which components of the SHR-coregulator complex are essential for transcription? Our study, published in @NAR_Open, used a FACS-based CRISPR screen to dissect the GR complex. academic.oup.com/nar/advance-ar… 🧵

@damirvareslija @Stefan_Prekovic @NAR_Open Thank you @damirvareslija !! ☺️☺️

@Stefan_Prekovic @IsabelMayayo @NAR_Open Congrats Isabel, Stefan and Wilbert. You’re all on fire another super story published!!

1/3 So proud to see the amazing work of our brilliant PhD student @IsabelMayayo published in @NAR_Open! I've had the privilege of witnessing her incredible growth & dedication. 🌟 Check out her detailed tweetorial for more information!

@RSiersbaek @zwartlab @NAR_Open @biorxivpreprint @NKI_nl @oncodeinstitute Thank you @RSiersbaek !! 😊😊

@zwartlab @NAR_Open @IsabelMayayo @biorxivpreprint @NKI_nl @oncodeinstitute Fantastic, nice to see this great work out🤩 Congrats Isabel, Stefan, Wilbert and the rest of them team!!

8/ A huge thank to my amazing promoter @zwartlab and co-promoter @Stefan_Prekovic for their invaluable guidance! Gratitude also goes to our fantastic collaborators @AHoutsmuller, @AltelaarM, and @NKI_nl and @oncodeinstitute, for their support in this research! #PAXIP1 #STAG2

7/GR & PAXIP1 bind the genome, inducing enhancer-promoter interactions. PAXIP1KO reduces cohesin binding to GR-sites, impairing transcription. PAXIP1KO may disrupt insulator loops & thereby increase gene expression. A fascinating interplay between PAXIP1, STAG2 & GR!

@AmitK_Dash @zwartlab Thanks! In a parallel study, van Schie JMM et al. looked at the role of PAXIP1 in mitosis, showing also to be important for cohesin function throughout the cell cycle. here the pre-print: biorxiv.org/content/10.110…

@zwartlab @IsabelMayayo Nice and interesting work. I am just wondering if you have checked this in any mitotic cell populations.

@MichalLaurent11 @Stefan_Prekovic Thanks @MichalLaurent11 !!

Check out our new preprint - biorxiv.org/content/10.110…. Anyone interested in co-regulators of transcription factors should definitely take a look. This work was led by our fantastic PhD student @IsabelMayayo

@z_pogacar @Stefan_Prekovic @zwartlab Thanks @z_pogacar !

A clever CRISPR screen identifying GR co-regulators, great work by @IsabelMayayo and @Stefan_Prekovic from @zwartlab!

@anthonymuler Thanks @anthonymuler !!

Amazing job done by @IsabelMayayo & co. Share it!!! #Science #nuclearreceptors #chip #glucocorticoid #phdlife #screens #preprints #CancerResearch

@AnnaGManjon @HFSP @TheCesareLab Congrats Anna!! 👏🏼👏🏼👏🏼

@AnnaGManjon @zwartlab @Stefan_Prekovic Thank you Anna ☺️☺️☺️

Really happy to share our latest work! @zwartlab @Stefan_Prekovic Check this out if you would like to know more about CDK4/6 inhibition in breast cancer! Thanks to all the collaborators for their fantastic contribution to this work ! mdpi.com/1407554

@Suz_Stelloo @LabVermeulen @NWO_Science Amazing news!! Congratulations @Suz_Stelloo !! 🎉🎉🎉

Incredibly honored to receive an NWO Veni grant to study protein dynamics during embryonic development @RIMLS_Science. Thanks to my amazing colleagues (@LabVermeulen and many more) and reviewers for their support and positive comments! Exciting times ahead! @NWO_Science