JAMA

📚 Read, share, and cite: Among patients with stage III resectable non-small cell lung cancer (#NSCLC) perioperative toripalimab plus platinum-based #chemotherapy improved event-free survival vs chemotherapy alone. The combination was also associated with a higher major pathological response rate and pathological complete response rate, with a manageable safety profile. 🔬 Conducting related research? Read and cite: ja.ma/4pU6LEd

💬 Perspective by Sandeep Kishore, MD, PhD, Pranay Narang, MS, and Andrew Auerbach, MD, MPH: Much of today’s #WearableData may function as results of unknown significance, appearing clinically useful without clear evidence, reference ranges, or defined roles in diagnosis and treatment. ja.ma/3RQrb4n

💬 Editor's Note by JAMA Executive Editor Gregory Curfman, MD: The US Food and Drug Administration and the Federal Trade Commission provide limited oversight for low-risk #DigitalHealth wellness devices, aiming to preserve innovation while requiring truthful, substantiated claims. ja.ma/4z9DDNw

Hodgkin lymphoma is a relatively rare disease, with approximately 82 409 incident cases reported globally in 2022, and 8720 cases reported in the US in 2025. Alison Moskowitz, MD, joined JAMA Deputy Editor Kristin Walter, MD, MS, to discuss current evidence about the diagnosis and management of Hodgkin lymphoma in adults. 🎧 Listen now: ja.ma/4fzv2ff

📝 JAMA #Review: #ClassicHodgkinLymphoma is usually treated with chemotherapy, with radiotherapy added for some early-stage disease and anti–programmed cell death 1 immunotherapy or brentuximab vedotin used in select higher-risk settings. ja.ma/4hQrjv4

For large-core #AcuteIschemicStroke selected by noncontrast computed tomography, intra-arterial #Thrombectomy was associated with better 1-year functional outcomes and quality of life vs medical management alone. ja.ma/4bunQ1A

📊 Research Summary: In metastatic #ColorectalCancer, high-dose vitamin D3 added to #chemotherapy and #bevacizumab did not improve progression-free survival vs standard-dose vitamin D3. ja.ma/4xkYewA

In metastatic #ColorectalCancer, adding high-dose vitamin D3 to chemotherapy plus bevacizumab did not improve progression-free survival vs standard-dose vitamin D3. ja.ma/4fB8evx

💬 Perspective: Much of today’s #WearableData may function as results of unknown significance, appearing clinically useful without clear evidence, reference ranges, or defined roles in diagnosis and treatment. ja.ma/3RQrb4n

💬 Viewpoint by @drjohnwhyte, MD, MPH, Chief Executive Officer and Executive Vice President of the @AmerMedicalAssn: Under the US Food and Drug Administration January 2026 guidance, many low-risk #DigitalHealth tools fall outside medical device oversight, but some may still influence health decisions without clear evidence standards. ja.ma/3TPttBi

Why and how should the government fund #biomedical #research? For the past 85 years, the US government has invested in research. A recent executive order and a related report from the Office of Management and Budget (OMB) seek to make major changes to the that funding. In the latest episode of #HealthyDialogue, Jeremy Berg, PhD, a former director of the National Institute of General Medical Sciences at the National Institutes of Health, discusses the history and future of science funding in the US. 🔗 Read the full article: ja.ma/4fVVHlw

In this podcast, JAMA Deputy Editors Linda Brubaker, MD, and Christopher Muth, MD, discussed the latest science published in JAMA: ➡️ Elevated LDL Cholesterol and Global Burden of Disease Analysis, ➡️ Intervention for Growth in Small-for-Gestational-Age Infants, ➡️ Cardiac Surgery and Dapagliflozin for AKI, and more. 🎧 Listen now: ja.ma/4hbDKS8

#MedNews: Blood tests for p-tau217, brain changes in former elite soccer players, and culturally tailored lifestyle interventions were among the highlights from #AAIC2026. ja.ma/4brJaVv

A text-delivered video #SafeSleep intervention for low-income families did not significantly improve reported usual supine sleep, room sharing without bed-sharing, soft bedding nonuse, or pacifier use. ja.ma/4wwjrn6

✅ Editor's Choice: Age-related macular degeneration (AMD) is a progressive #retinal disorder and a leading cause of severe vision impairment in older adults. Late-stage disease presents as geographic atrophy or exudative neovascular AMD, and intravitreally administered anti-vascular endothelial growth factor treatment is the first-line therapy for exudative neovascular AMD. 💾 Save it for your bibliography: ja.ma/4hKfpTt

📊 JAMA Clinical Guidelines Synopsis: The newly released Surviving #Sepsis Campaign guidelines from ESICM and SCCM endorse early broad-spectrum antibiotics, rapid fluid resuscitation, and deescalation strategies for adults with sepsis or septic shock. ja.ma/4xluZd6

Atherosclerotic #cardiovascular disease (ASCVD) remains a leading cause of global #mortality and is strongly associated with cumulative exposure to atherogenic lipoproteins across the lifespan. 🎙️ Listen to Amber Johnson, MD, MS, MBA, discuss the 2026 dyslipidemia guideline with JAMA Senior Editor Philip Greenland, MD: ja.ma/4wweHxO

💬 Editorial by Wolfgang Winkelmayer, MD, MPH, ScD, and Glenn Chertow, MD, MPH: Perioperative #dapagliflozin reduced postoperative #AcuteKidneyInjury after elective cardiac surgery, supporting further trials of sodium-glucose cotransporter 2 inhibitors for kidney protection. ja.ma/4bpXaiv

Among patients undergoing elective cardiac surgery, perioperative #dapagliflozin reduced postoperative #AcuteKidneyInjury compared with placebo over 7 days. ja.ma/3Tpo04a

Ten years after the US Centers for Disease Control and Prevention first issued #opioid prescribing guidance, clinicians are still balancing caution about #addiction risk with the need to treat pain effectively. 🎙️ Listen to Kate Schweitzer and Samantha Anderer discuss the latest in JAMA Medical News: ja.ma/4qcNA8V